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- W4386001920 abstract "Abstract Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. The aim of this study was to investigate the role of mitotic regulator Polo-like kinase 1 (PLK1) in PH development. Methods Mouse lungs along with human pulmonary arterial smooth muscle cells and endothelial cells were used to investigate the effects of hypoxia on PLK1. Hypoxia- or Sugen5416/hypoxia was applied to induce PH in mice. Plk1 heterozygous knockout mice and PLK1 inhibitors (BI 2536 and BI 6727)-treated mice were checked for the significance of PLK1 in the development of PH. Results Hypoxia stimulated PLK1 expression through induction of HIF1α and RELA. Mice with heterozygous deletion of Plk1 were partially resistant to hypoxia-induced PH. PLK1 inhibitors ameliorated PH in mice. Conclusions Augmented PLK1 is essential for the development of PH and is a druggable target for PH." @default.
- W4386001920 created "2023-08-20" @default.
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- W4386001920 date "2023-08-19" @default.
- W4386001920 modified "2023-10-17" @default.
- W4386001920 title "Polo-like kinase 1 promotes pulmonary hypertension" @default.
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- W4386001920 doi "https://doi.org/10.1186/s12931-023-02498-z" @default.
- W4386001920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598171" @default.
- W4386001920 hasPublicationYear "2023" @default.
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