Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386002108> ?p ?o ?g. }
- W4386002108 endingPage "2717" @default.
- W4386002108 startingPage "2701" @default.
- W4386002108 abstract "The prominence of autophagy in the modulation of neurodegenerative disorders has sparked interest to investigate its stimulation in Alzheimer's disease (AD). Nobiletin possesses several bioactivities such as anti-inflammation, antioxidation, and neuroprotection. Consequently, the study's aim was to inspect the possible neurotherapeutic impact of Nobiletin in damping AD through autophagy regulation. Mice were randomly assigned into: Group I which received DMSO, Groups II, III, and IV obtained STZ (3 mg/kg) intracerebroventricularly once with Nobiletin (50 mg/kg/day; i.p.) in Group III and Nobiletin with EX-527 (2 mg/kg, i.p.) in Group IV. Interestingly, Nobiletin ameliorated STZ-induced AD through enhancing the motor performance and repressing memory defects. Moreover, Nobiletin de-escalated hippocampal acetylcholinesterase (AChE) activity and enhanced acetylcholine level while halting BACE1 and amyloid-β levels. Meanwhile, Nobiletin stimulated the autophagy process through activating the SIRT1/FoxO3a, LC3B-II, and ATG7 pathway. Additionally, Nobiletin inhibited Akt pathway and controlled the level of NF-κB and TNF-α. Nobiletin amended the oxidative stress through enhancing GSH and cutting down MDA levels. However, EX527, SIRT1 inhibitor, counteracted the neurotherapeutic effects of Nobiletin. Therefore, the present study provides a strong verification for the therapeutic influence of Nobiletin in AD. This outcome may be assigned to autophagy stimulation through SIRT1/FoxO3a, inhibiting AChE activity, reducing neuroinflammation and oxidative stress." @default.
- W4386002108 created "2023-08-20" @default.
- W4386002108 creator A5023030567 @default.
- W4386002108 creator A5035986735 @default.
- W4386002108 creator A5058110037 @default.
- W4386002108 creator A5084866591 @default.
- W4386002108 date "2023-08-19" @default.
- W4386002108 modified "2023-10-12" @default.
- W4386002108 title "The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism" @default.
- W4386002108 cites W1540228912 @default.
- W4386002108 cites W1949878994 @default.
- W4386002108 cites W1965185022 @default.
- W4386002108 cites W1965594477 @default.
- W4386002108 cites W1965627667 @default.
- W4386002108 cites W1967513458 @default.
- W4386002108 cites W1968098522 @default.
- W4386002108 cites W1970694369 @default.
- W4386002108 cites W1972340735 @default.
- W4386002108 cites W1975692706 @default.
- W4386002108 cites W1976601848 @default.
- W4386002108 cites W1980990713 @default.
- W4386002108 cites W1982967474 @default.
- W4386002108 cites W1983523416 @default.
- W4386002108 cites W1984330532 @default.
- W4386002108 cites W1985401645 @default.
- W4386002108 cites W1988772292 @default.
- W4386002108 cites W1992108524 @default.
- W4386002108 cites W1996612604 @default.
- W4386002108 cites W1998949081 @default.
- W4386002108 cites W2005933787 @default.
- W4386002108 cites W2006370393 @default.
- W4386002108 cites W2008166785 @default.
- W4386002108 cites W2008366409 @default.
- W4386002108 cites W2012529359 @default.
- W4386002108 cites W2014227309 @default.
- W4386002108 cites W2033893668 @default.
- W4386002108 cites W2038919575 @default.
- W4386002108 cites W2039392338 @default.
- W4386002108 cites W2043095760 @default.
- W4386002108 cites W2046205800 @default.
- W4386002108 cites W2046359431 @default.
- W4386002108 cites W2053054955 @default.
- W4386002108 cites W2053079047 @default.
- W4386002108 cites W2053116497 @default.
- W4386002108 cites W2053176849 @default.
- W4386002108 cites W2057203166 @default.
- W4386002108 cites W2059467226 @default.
- W4386002108 cites W2066784983 @default.
- W4386002108 cites W2067360604 @default.
- W4386002108 cites W2073074836 @default.
- W4386002108 cites W2087019589 @default.
- W4386002108 cites W2087835012 @default.
- W4386002108 cites W2088538089 @default.
- W4386002108 cites W2091449183 @default.
- W4386002108 cites W2091492780 @default.
- W4386002108 cites W2093620881 @default.
- W4386002108 cites W2102614059 @default.
- W4386002108 cites W2106765180 @default.
- W4386002108 cites W2114022129 @default.
- W4386002108 cites W2117119983 @default.
- W4386002108 cites W2120234533 @default.
- W4386002108 cites W2128537698 @default.
- W4386002108 cites W2128635872 @default.
- W4386002108 cites W2128677681 @default.
- W4386002108 cites W2131767872 @default.
- W4386002108 cites W2140925956 @default.
- W4386002108 cites W2144602958 @default.
- W4386002108 cites W2145107163 @default.
- W4386002108 cites W2149450071 @default.
- W4386002108 cites W2164535032 @default.
- W4386002108 cites W2165329538 @default.
- W4386002108 cites W2177656518 @default.
- W4386002108 cites W2301502393 @default.
- W4386002108 cites W2337535943 @default.
- W4386002108 cites W2402015540 @default.
- W4386002108 cites W2488794301 @default.
- W4386002108 cites W2489724250 @default.
- W4386002108 cites W2557887080 @default.
- W4386002108 cites W2593034833 @default.
- W4386002108 cites W2604480729 @default.
- W4386002108 cites W2616890438 @default.
- W4386002108 cites W2618288435 @default.
- W4386002108 cites W2752481628 @default.
- W4386002108 cites W2752591735 @default.
- W4386002108 cites W2770706758 @default.
- W4386002108 cites W2800936753 @default.
- W4386002108 cites W2804267327 @default.
- W4386002108 cites W2885138532 @default.
- W4386002108 cites W2886484225 @default.
- W4386002108 cites W2886816856 @default.
- W4386002108 cites W2900477457 @default.
- W4386002108 cites W2902058990 @default.
- W4386002108 cites W2939674581 @default.
- W4386002108 cites W2941999541 @default.
- W4386002108 cites W2961915187 @default.
- W4386002108 cites W2964111426 @default.
- W4386002108 cites W2974441752 @default.
- W4386002108 cites W3000945988 @default.