Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386002376> ?p ?o ?g. }
- W4386002376 endingPage "175986" @default.
- W4386002376 startingPage "175986" @default.
- W4386002376 abstract "Colorectal cancer (CRC) is the third most common cancer, and is one of the leading causes of cancer-related death worldwide. At the time of diagnosis, about 20% of patients with CRC present metastatic disease. Regorafenib, an oral multi-kinase inhibitor, has been demonstrated the efficacy and tolerability in patients with metastatic CRC. Oxaliplatin is a frontline treatment regimen for CRC, and combination treatments with oxaliplatin and other chemotherapeutic agents exert superior therapeutic effects. However, side effects and drug resistance limited their further clinical application. Here, we found that combined treatment with regorafenib and oxaliplatin synergistically enhanced anti-tumor activities in CRC by activating reactive oxygen species (ROS) mediated endoplasmic reticulum (ER) stress, C-Jun-amino-terminal kinase (JNK) and p38 signaling pathways. Regorafenib promoted ROS production by suppressing the expression of selenoprotein S (SELENOS). Knocking down SELENOS sensitized ROS-mediated anti-tumor effects of regorafenib in CRC cells. Furthermore, mouse xenograft models demonstrated that synergistic anti-tumor effects of combined treatment with regorafenib and oxaliplatin. This study provided solid experimental evidences for the combined treatment with regorafenib and oxaliplatin in CRC." @default.
- W4386002376 created "2023-08-20" @default.
- W4386002376 creator A5000417280 @default.
- W4386002376 creator A5005243122 @default.
- W4386002376 creator A5020207914 @default.
- W4386002376 creator A5028523899 @default.
- W4386002376 creator A5033563196 @default.
- W4386002376 creator A5035804461 @default.
- W4386002376 creator A5037147271 @default.
- W4386002376 creator A5045236925 @default.
- W4386002376 creator A5046753601 @default.
- W4386002376 creator A5050075582 @default.
- W4386002376 creator A5050479490 @default.
- W4386002376 creator A5052565646 @default.
- W4386002376 creator A5063848735 @default.
- W4386002376 creator A5089396499 @default.
- W4386002376 creator A5091903803 @default.
- W4386002376 date "2023-10-01" @default.
- W4386002376 modified "2023-10-07" @default.
- W4386002376 title "Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells" @default.
- W4386002376 cites W1504814099 @default.
- W4386002376 cites W1666046628 @default.
- W4386002376 cites W1968209756 @default.
- W4386002376 cites W1969524738 @default.
- W4386002376 cites W1972553181 @default.
- W4386002376 cites W1972779889 @default.
- W4386002376 cites W1976385326 @default.
- W4386002376 cites W1977178308 @default.
- W4386002376 cites W1979098327 @default.
- W4386002376 cites W2001171142 @default.
- W4386002376 cites W2008342394 @default.
- W4386002376 cites W2011181458 @default.
- W4386002376 cites W2015715866 @default.
- W4386002376 cites W2016373146 @default.
- W4386002376 cites W2024640050 @default.
- W4386002376 cites W2056963346 @default.
- W4386002376 cites W2084472730 @default.
- W4386002376 cites W2101101724 @default.
- W4386002376 cites W2113554382 @default.
- W4386002376 cites W2128625686 @default.
- W4386002376 cites W2130177169 @default.
- W4386002376 cites W2133812267 @default.
- W4386002376 cites W2139241036 @default.
- W4386002376 cites W2155581805 @default.
- W4386002376 cites W2600452401 @default.
- W4386002376 cites W2744535327 @default.
- W4386002376 cites W2795974312 @default.
- W4386002376 cites W2796244182 @default.
- W4386002376 cites W2802634838 @default.
- W4386002376 cites W2814289209 @default.
- W4386002376 cites W2905260835 @default.
- W4386002376 cites W2915611666 @default.
- W4386002376 cites W2919792178 @default.
- W4386002376 cites W2921269539 @default.
- W4386002376 cites W2935622333 @default.
- W4386002376 cites W2974834475 @default.
- W4386002376 cites W2982214764 @default.
- W4386002376 cites W3000861867 @default.
- W4386002376 cites W3009425243 @default.
- W4386002376 cites W3022826582 @default.
- W4386002376 cites W3029014793 @default.
- W4386002376 cites W3128646645 @default.
- W4386002376 cites W3134999190 @default.
- W4386002376 cites W3157147860 @default.
- W4386002376 cites W3158926365 @default.
- W4386002376 cites W3160473494 @default.
- W4386002376 cites W3164109642 @default.
- W4386002376 cites W3174451008 @default.
- W4386002376 cites W3207261967 @default.
- W4386002376 cites W3209066571 @default.
- W4386002376 cites W3209485055 @default.
- W4386002376 cites W4206935800 @default.
- W4386002376 cites W4210301812 @default.
- W4386002376 cites W4315754639 @default.
- W4386002376 cites W4322719806 @default.
- W4386002376 doi "https://doi.org/10.1016/j.ejphar.2023.175986" @default.
- W4386002376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598924" @default.
- W4386002376 hasPublicationYear "2023" @default.
- W4386002376 type Work @default.
- W4386002376 citedByCount "0" @default.
- W4386002376 crossrefType "journal-article" @default.
- W4386002376 hasAuthorship W4386002376A5000417280 @default.
- W4386002376 hasAuthorship W4386002376A5005243122 @default.
- W4386002376 hasAuthorship W4386002376A5020207914 @default.
- W4386002376 hasAuthorship W4386002376A5028523899 @default.
- W4386002376 hasAuthorship W4386002376A5033563196 @default.
- W4386002376 hasAuthorship W4386002376A5035804461 @default.
- W4386002376 hasAuthorship W4386002376A5037147271 @default.
- W4386002376 hasAuthorship W4386002376A5045236925 @default.
- W4386002376 hasAuthorship W4386002376A5046753601 @default.
- W4386002376 hasAuthorship W4386002376A5050075582 @default.
- W4386002376 hasAuthorship W4386002376A5050479490 @default.
- W4386002376 hasAuthorship W4386002376A5052565646 @default.
- W4386002376 hasAuthorship W4386002376A5063848735 @default.
- W4386002376 hasAuthorship W4386002376A5089396499 @default.
- W4386002376 hasAuthorship W4386002376A5091903803 @default.
- W4386002376 hasConcept C121608353 @default.
- W4386002376 hasConcept C126322002 @default.