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• W4386002455 startingPage "115746" @default.
• W4386002455 abstract "Inducing protein degradation by proteolysis targeting chimera (PROTAC) has provided great opportunities for scientific research and industrial applications. Histone deacetylase (HDAC)-PROTAC has been widely developed since the first report of its ability to induce the degradation of SIRT2 in 2017. To date, ten of the eighteen HDACs (HDACs 1-8, HDAC10, and SIRT2) have been successfully targeted and degraded by HDAC-PROTACs. HDAC-PROTACs surpass traditional HDAC inhibitors in many aspects, such as higher selectivity, more potent antiproliferative activity, and the ability to disrupt the enzyme-independent functions of a multifunctional protein and overcome drug resistance. Rationally designing HDAC-PROTACs is a main challenge in development because slight variations in chemical structure can lead to drastic effects on the efficiency and selectivity of the degradation. In the future, HDAC-PROTACs can potentially be involved in clinical research with the support of the increased amount of in vivo data, pharmacokinetic evaluation, and pharmacological studies." @default.
• W4386002455 created "2023-08-20" @default.
• W4386002455 creator A5001185510 @default.
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• W4386002455 creator A5086682186 @default.
• W4386002455 date "2023-11-01" @default.
• W4386002455 modified "2023-10-12" @default.
• W4386002455 title "The application of PROTAC in HDAC" @default.
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