Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386002616> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4386002616 endingPage "115652" @default.
- W4386002616 startingPage "115652" @default.
- W4386002616 abstract "A fast and reliable QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method for pre-processing combined with Ultra - high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS) was established for the analysis of five mammalian rapamycin target protein (mTOR) inhibitors (vistusertib, AZD8055, pictilisib, everolimus, temsirolimus)in human plasma. Extraction was achieved by addition of acetonitrile to the sample followed by anhydrous magnesium sulfate and 30 mg C18 for salting out and purification, respectively. MTOR inhibitors were detected using selective response monitoring (SRM) under positive ion electrospray mode. Vistusertib, AZD8055 and pictilisib showed good linearity with a range of 1-80 ng/ml, Additionally, the concentration of everolimus and temsirolimus was 2.5-200 ng/ml and10-800 ng/ml, respectively. The linear correlation coefficient (R2) of each analysis was ≥ 0.9950. The limit of detection (LOD) and Limit of Quantitation (LOQ) were 0.015-0.75 ng/ml and 1-10 ng/ml, respectively. This method showed a high accuracy with high recovery rate and excellent stability. This method is fast, accurate and reliable, suitable for quantitative detection of mTOR inhibitors in human plasma." @default.
- W4386002616 created "2023-08-20" @default.
- W4386002616 creator A5027459729 @default.
- W4386002616 creator A5037642048 @default.
- W4386002616 creator A5049071926 @default.
- W4386002616 creator A5065859286 @default.
- W4386002616 creator A5068080767 @default.
- W4386002616 creator A5077176186 @default.
- W4386002616 date "2023-10-01" @default.
- W4386002616 modified "2023-10-07" @default.
- W4386002616 title "Determination of five mTOR inhibitors in human plasma for hepatocellular carcinoma treatment using QuEChERS-UHPLC-MS/MS" @default.
- W4386002616 cites W1986244174 @default.
- W4386002616 cites W1986368997 @default.
- W4386002616 cites W1992512309 @default.
- W4386002616 cites W2045375909 @default.
- W4386002616 cites W2051905099 @default.
- W4386002616 cites W2106529798 @default.
- W4386002616 cites W2106855195 @default.
- W4386002616 cites W2494188136 @default.
- W4386002616 cites W2606470442 @default.
- W4386002616 cites W2913737491 @default.
- W4386002616 cites W2954917865 @default.
- W4386002616 cites W2965511964 @default.
- W4386002616 cites W2991287203 @default.
- W4386002616 cites W3048102544 @default.
- W4386002616 cites W3093041491 @default.
- W4386002616 cites W3113090937 @default.
- W4386002616 cites W3118511219 @default.
- W4386002616 cites W3176165488 @default.
- W4386002616 cites W3210919633 @default.
- W4386002616 cites W4280592682 @default.
- W4386002616 cites W4313479863 @default.
- W4386002616 cites W4321769514 @default.
- W4386002616 cites W4362472474 @default.
- W4386002616 cites W4385216217 @default.
- W4386002616 doi "https://doi.org/10.1016/j.jpba.2023.115652" @default.
- W4386002616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37633163" @default.
- W4386002616 hasPublicationYear "2023" @default.
- W4386002616 type Work @default.
- W4386002616 citedByCount "0" @default.
- W4386002616 crossrefType "journal-article" @default.
- W4386002616 hasAuthorship W4386002616A5027459729 @default.
- W4386002616 hasAuthorship W4386002616A5037642048 @default.
- W4386002616 hasAuthorship W4386002616A5049071926 @default.
- W4386002616 hasAuthorship W4386002616A5065859286 @default.
- W4386002616 hasAuthorship W4386002616A5068080767 @default.
- W4386002616 hasAuthorship W4386002616A5077176186 @default.
- W4386002616 hasConcept C106848363 @default.
- W4386002616 hasConcept C119128265 @default.
- W4386002616 hasConcept C126322002 @default.
- W4386002616 hasConcept C161176658 @default.
- W4386002616 hasConcept C162356407 @default.
- W4386002616 hasConcept C185592680 @default.
- W4386002616 hasConcept C2775926907 @default.
- W4386002616 hasConcept C2779699572 @default.
- W4386002616 hasConcept C31827203 @default.
- W4386002616 hasConcept C43617362 @default.
- W4386002616 hasConcept C64489805 @default.
- W4386002616 hasConcept C6557445 @default.
- W4386002616 hasConcept C71043704 @default.
- W4386002616 hasConcept C71924100 @default.
- W4386002616 hasConcept C74774607 @default.
- W4386002616 hasConcept C86803240 @default.
- W4386002616 hasConceptScore W4386002616C106848363 @default.
- W4386002616 hasConceptScore W4386002616C119128265 @default.
- W4386002616 hasConceptScore W4386002616C126322002 @default.
- W4386002616 hasConceptScore W4386002616C161176658 @default.
- W4386002616 hasConceptScore W4386002616C162356407 @default.
- W4386002616 hasConceptScore W4386002616C185592680 @default.
- W4386002616 hasConceptScore W4386002616C2775926907 @default.
- W4386002616 hasConceptScore W4386002616C2779699572 @default.
- W4386002616 hasConceptScore W4386002616C31827203 @default.
- W4386002616 hasConceptScore W4386002616C43617362 @default.
- W4386002616 hasConceptScore W4386002616C64489805 @default.
- W4386002616 hasConceptScore W4386002616C6557445 @default.
- W4386002616 hasConceptScore W4386002616C71043704 @default.
- W4386002616 hasConceptScore W4386002616C71924100 @default.
- W4386002616 hasConceptScore W4386002616C74774607 @default.
- W4386002616 hasConceptScore W4386002616C86803240 @default.
- W4386002616 hasFunder F4320322163 @default.
- W4386002616 hasLocation W43860026161 @default.
- W4386002616 hasLocation W43860026162 @default.
- W4386002616 hasOpenAccess W4386002616 @default.
- W4386002616 hasPrimaryLocation W43860026161 @default.
- W4386002616 hasRelatedWork W1998032538 @default.
- W4386002616 hasRelatedWork W2065515467 @default.
- W4386002616 hasRelatedWork W2401634582 @default.
- W4386002616 hasRelatedWork W2415050782 @default.
- W4386002616 hasRelatedWork W2559994380 @default.
- W4386002616 hasRelatedWork W2998178230 @default.
- W4386002616 hasRelatedWork W3009677990 @default.
- W4386002616 hasRelatedWork W3131457855 @default.
- W4386002616 hasRelatedWork W4253469128 @default.
- W4386002616 hasRelatedWork W4360974638 @default.
- W4386002616 hasVolume "235" @default.
- W4386002616 isParatext "false" @default.
- W4386002616 isRetracted "false" @default.
- W4386002616 workType "article" @default.