Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386002772> ?p ?o ?g. }
- W4386002772 endingPage "55" @default.
- W4386002772 startingPage "47" @default.
- W4386002772 abstract "Dementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease (AD) and vascular pathologies. We evaluated domain-specific cognitive and neuropsychiatric dysfunction using a two-neuroimaging biomarker construct (beta-amyloid [Aβ] and cerebrovascular disease [CeVD]). We analyzed data from 216 memory clinic participants (mean age = 75.9 ± 6.9; 56.5% female) with neuropsychological and neuropsychiatric assessments, 3T-MRI, and Aβ-PET imaging. Structural equation modeling showed that the largest Aβ (A+) effect was on memory (B = -1.50) and apathy (B = 0.26), whereas CeVD effects were largest on language (B = -1.62) and hyperactivity (B = 0.32). Group comparisons showed that the A+C+ group had greater memory impairment (B = -1.55), hyperactivity (B = 0.79), and apathy (B = 0.74) compared to A-C+; and greater language impairment (B = -1.26) compared to A+C-. These potentially additive effects of Aβ and CeVD burden underline the importance of early detection and treatment of Aβ alongside optimal control of vascular risk factors as a potential strategy in preventing cognitive and neurobehavioral impairment." @default.
- W4386002772 created "2023-08-20" @default.
- W4386002772 creator A5005221930 @default.
- W4386002772 creator A5006436645 @default.
- W4386002772 creator A5008989080 @default.
- W4386002772 creator A5022789521 @default.
- W4386002772 creator A5040482050 @default.
- W4386002772 creator A5051780206 @default.
- W4386002772 creator A5062885337 @default.
- W4386002772 creator A5063016255 @default.
- W4386002772 creator A5065625682 @default.
- W4386002772 date "2023-12-01" @default.
- W4386002772 modified "2023-10-17" @default.
- W4386002772 title "Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study" @default.
- W4386002772 cites W1966601502 @default.
- W4386002772 cites W1972661606 @default.
- W4386002772 cites W1983295300 @default.
- W4386002772 cites W2003061822 @default.
- W4386002772 cites W2006532470 @default.
- W4386002772 cites W2023702077 @default.
- W4386002772 cites W2043298511 @default.
- W4386002772 cites W2043522411 @default.
- W4386002772 cites W2043794099 @default.
- W4386002772 cites W2046601821 @default.
- W4386002772 cites W2048064494 @default.
- W4386002772 cites W2075322089 @default.
- W4386002772 cites W2077589737 @default.
- W4386002772 cites W2095132657 @default.
- W4386002772 cites W2095579469 @default.
- W4386002772 cites W2096197732 @default.
- W4386002772 cites W2103727971 @default.
- W4386002772 cites W2104901197 @default.
- W4386002772 cites W2112150247 @default.
- W4386002772 cites W2113082716 @default.
- W4386002772 cites W2124681501 @default.
- W4386002772 cites W2134711807 @default.
- W4386002772 cites W2138306169 @default.
- W4386002772 cites W2138883123 @default.
- W4386002772 cites W2148651129 @default.
- W4386002772 cites W2158742097 @default.
- W4386002772 cites W2169683146 @default.
- W4386002772 cites W2254174746 @default.
- W4386002772 cites W2328932654 @default.
- W4386002772 cites W2484481324 @default.
- W4386002772 cites W2530117917 @default.
- W4386002772 cites W2560999412 @default.
- W4386002772 cites W2582524520 @default.
- W4386002772 cites W2597317078 @default.
- W4386002772 cites W2752689298 @default.
- W4386002772 cites W2796773068 @default.
- W4386002772 cites W2887458865 @default.
- W4386002772 cites W2914833179 @default.
- W4386002772 cites W2922967568 @default.
- W4386002772 cites W2985909296 @default.
- W4386002772 cites W2996085106 @default.
- W4386002772 cites W2997038615 @default.
- W4386002772 cites W3091941074 @default.
- W4386002772 cites W3132321216 @default.
- W4386002772 cites W3205202121 @default.
- W4386002772 cites W4254703930 @default.
- W4386002772 cites W4300689971 @default.
- W4386002772 cites W4307228020 @default.
- W4386002772 cites W4310461604 @default.
- W4386002772 cites W577743257 @default.
- W4386002772 doi "https://doi.org/10.1016/j.neurobiolaging.2023.08.005" @default.
- W4386002772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37729769" @default.
- W4386002772 hasPublicationYear "2023" @default.
- W4386002772 type Work @default.
- W4386002772 citedByCount "0" @default.
- W4386002772 crossrefType "journal-article" @default.
- W4386002772 hasAuthorship W4386002772A5005221930 @default.
- W4386002772 hasAuthorship W4386002772A5006436645 @default.
- W4386002772 hasAuthorship W4386002772A5008989080 @default.
- W4386002772 hasAuthorship W4386002772A5022789521 @default.
- W4386002772 hasAuthorship W4386002772A5040482050 @default.
- W4386002772 hasAuthorship W4386002772A5051780206 @default.
- W4386002772 hasAuthorship W4386002772A5062885337 @default.
- W4386002772 hasAuthorship W4386002772A5063016255 @default.
- W4386002772 hasAuthorship W4386002772A5065625682 @default.
- W4386002772 hasConcept C118552586 @default.
- W4386002772 hasConcept C126322002 @default.
- W4386002772 hasConcept C14216870 @default.
- W4386002772 hasConcept C15744967 @default.
- W4386002772 hasConcept C169900460 @default.
- W4386002772 hasConcept C185592680 @default.
- W4386002772 hasConcept C2776509080 @default.
- W4386002772 hasConcept C2776656118 @default.
- W4386002772 hasConcept C2779134260 @default.
- W4386002772 hasConcept C2779483572 @default.
- W4386002772 hasConcept C2781197716 @default.
- W4386002772 hasConcept C3018842126 @default.
- W4386002772 hasConcept C502032728 @default.
- W4386002772 hasConcept C55493867 @default.
- W4386002772 hasConcept C58693492 @default.
- W4386002772 hasConcept C71924100 @default.
- W4386002772 hasConcept C88576662 @default.
- W4386002772 hasConceptScore W4386002772C118552586 @default.
- W4386002772 hasConceptScore W4386002772C126322002 @default.