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- W4386002775 endingPage "100101" @default.
- W4386002775 startingPage "100101" @default.
- W4386002775 abstract "RNA molecules play essential roles in many biological functions, from gene expression regulation, cellular growth, and metabolism to catalysis. They frequently fold into three-dimensional structures to perform their functions. Therefore, determining RNA structure represents a key step for understanding the structure-function relationships and developing RNA-targeted therapeutics. X-ray crystallography remains a method of choice for determining high-resolution RNA structures, but it has been challenging due to difficulties associated with RNA crystallization and phasing. Several natural and synthetic RNA binding proteins have been used to facilitate RNA crystallography. Having unique properties to help crystal packing and phasing, synthetic antibody fragments, specifically the Fabs, have emerged as promising RNA crystallization chaperones, and so far, over a dozen of RNA structures have been solved using this strategy. Nevertheless, multiple steps in this approach need to be improved, including the recombinant expression of these anti-RNA Fabs, to warrant the full potential of these synthetic Fabs as RNA crystallization chaperones. This review highlights the nuts and bolts and recent advances in the chaperone-assisted RNA crystallography approach, specifically emphasizing the Fab antibody fragments as RNA crystallization chaperones." @default.
- W4386002775 created "2023-08-20" @default.
- W4386002775 creator A5042334471 @default.
- W4386002775 creator A5044841092 @default.
- W4386002775 creator A5062143442 @default.
- W4386002775 creator A5066445397 @default.
- W4386002775 date "2023-01-01" @default.
- W4386002775 modified "2023-09-26" @default.
- W4386002775 title "Advances in chaperone-assisted RNA crystallography using synthetic antibodies" @default.
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