Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386002961> ?p ?o ?g. }
- W4386002961 endingPage "109006" @default.
- W4386002961 startingPage "109006" @default.
- W4386002961 abstract "Myeloid differentiation primary response protein-88 (MYD88) is an essential adaptor molecule in pathogen-related pattern recognition signaling pathways. Toll-like and interleukin receptors recognize numerous signals and are funneled through MyD88 to express genes responsible for the innate and adaptive immune systems. In the present study, the relevance of MyD88 in viral hemorrhagic septicemia virus (VHSV) was investigated by generating myd88-/- zebrafish. The model was challenged with VHSV, and viral propagation was quantified by evaluating clinical symptoms, mortality, and VHSV copy number. The infected fish showed abnormal morphologies, such as subcutaneous hemorrhages, abdominal swelling, and bulging eyes, which were comparatively more intense in myd88-/- fish than in the wild-type. An injury infection experiment conducted in zebrafish larvae indicated a substantial spread of VHSV in the wound site. The number of neutrophils and macrophages recruited to the wounded area were markedly reduced in myd88-/- fish. According to gene expression analysis, VHSV NP gene expression was considerably upregulated in myd88-/- fish. Substantial gene expression and immune cell marker modulation were observed in the mutant model compared to that in the wild-type. These results suggest that the lack of a significant adaptor protein for immune signal transduction results in enhanced VHSV replication." @default.
- W4386002961 created "2023-08-20" @default.
- W4386002961 creator A5018339930 @default.
- W4386002961 creator A5039556348 @default.
- W4386002961 creator A5068907947 @default.
- W4386002961 creator A5072494737 @default.
- W4386002961 creator A5082178299 @default.
- W4386002961 date "2023-10-01" @default.
- W4386002961 modified "2023-10-07" @default.
- W4386002961 title "Ablation of myd88 alters the immune gene expression and immune cell recruitment during VHSV infection in zebrafish" @default.
- W4386002961 cites W1487281579 @default.
- W4386002961 cites W1563798247 @default.
- W4386002961 cites W1583006772 @default.
- W4386002961 cites W1912701812 @default.
- W4386002961 cites W1928414651 @default.
- W4386002961 cites W1967285463 @default.
- W4386002961 cites W1971800474 @default.
- W4386002961 cites W1985968246 @default.
- W4386002961 cites W1997913447 @default.
- W4386002961 cites W2006439216 @default.
- W4386002961 cites W2018722698 @default.
- W4386002961 cites W2051887848 @default.
- W4386002961 cites W2053188090 @default.
- W4386002961 cites W2054472394 @default.
- W4386002961 cites W2054538838 @default.
- W4386002961 cites W2057832232 @default.
- W4386002961 cites W2069463594 @default.
- W4386002961 cites W2072578754 @default.
- W4386002961 cites W2090640877 @default.
- W4386002961 cites W2090821317 @default.
- W4386002961 cites W2096402064 @default.
- W4386002961 cites W2098485561 @default.
- W4386002961 cites W2107277218 @default.
- W4386002961 cites W2108844078 @default.
- W4386002961 cites W2109491705 @default.
- W4386002961 cites W2117396143 @default.
- W4386002961 cites W2119910602 @default.
- W4386002961 cites W2133570598 @default.
- W4386002961 cites W2157146227 @default.
- W4386002961 cites W2158738222 @default.
- W4386002961 cites W2168954781 @default.
- W4386002961 cites W2290894305 @default.
- W4386002961 cites W2301955528 @default.
- W4386002961 cites W2766063046 @default.
- W4386002961 cites W2770652996 @default.
- W4386002961 cites W2780629397 @default.
- W4386002961 cites W2790807197 @default.
- W4386002961 cites W2801416911 @default.
- W4386002961 cites W2889912068 @default.
- W4386002961 cites W2916986084 @default.
- W4386002961 cites W2939408967 @default.
- W4386002961 cites W2971410032 @default.
- W4386002961 cites W2972839394 @default.
- W4386002961 cites W2981806282 @default.
- W4386002961 cites W3000502359 @default.
- W4386002961 cites W3004118700 @default.
- W4386002961 cites W3006585076 @default.
- W4386002961 cites W3031288572 @default.
- W4386002961 cites W3126509650 @default.
- W4386002961 cites W3127754903 @default.
- W4386002961 cites W3159181663 @default.
- W4386002961 cites W4307374052 @default.
- W4386002961 cites W4307658337 @default.
- W4386002961 cites W4362663551 @default.
- W4386002961 doi "https://doi.org/10.1016/j.fsi.2023.109006" @default.
- W4386002961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598733" @default.
- W4386002961 hasPublicationYear "2023" @default.
- W4386002961 type Work @default.
- W4386002961 citedByCount "0" @default.
- W4386002961 crossrefType "journal-article" @default.
- W4386002961 hasAuthorship W4386002961A5018339930 @default.
- W4386002961 hasAuthorship W4386002961A5039556348 @default.
- W4386002961 hasAuthorship W4386002961A5068907947 @default.
- W4386002961 hasAuthorship W4386002961A5072494737 @default.
- W4386002961 hasAuthorship W4386002961A5082178299 @default.
- W4386002961 hasConcept C104317684 @default.
- W4386002961 hasConcept C136449434 @default.
- W4386002961 hasConcept C159047783 @default.
- W4386002961 hasConcept C183786373 @default.
- W4386002961 hasConcept C193419808 @default.
- W4386002961 hasConcept C203014093 @default.
- W4386002961 hasConcept C2776878037 @default.
- W4386002961 hasConcept C54355233 @default.
- W4386002961 hasConcept C62478195 @default.
- W4386002961 hasConcept C86803240 @default.
- W4386002961 hasConcept C8891405 @default.
- W4386002961 hasConcept C95444343 @default.
- W4386002961 hasConceptScore W4386002961C104317684 @default.
- W4386002961 hasConceptScore W4386002961C136449434 @default.
- W4386002961 hasConceptScore W4386002961C159047783 @default.
- W4386002961 hasConceptScore W4386002961C183786373 @default.
- W4386002961 hasConceptScore W4386002961C193419808 @default.
- W4386002961 hasConceptScore W4386002961C203014093 @default.
- W4386002961 hasConceptScore W4386002961C2776878037 @default.
- W4386002961 hasConceptScore W4386002961C54355233 @default.
- W4386002961 hasConceptScore W4386002961C62478195 @default.
- W4386002961 hasConceptScore W4386002961C86803240 @default.
- W4386002961 hasConceptScore W4386002961C8891405 @default.