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- W4386003020 abstract "Accurate quantification of the BCR::ABL1 transcripts is essential for measurable residual disease (MRD) monitoring in chronic myeloid leukaemia (CML) after tyrosine kinase inhibitor (TKI) treatment. This study evaluated the newly developed digital real-time PCR method, Dr. PCR, as an alternative reverse transcription-PCR (qRT-PCR) for MRD detection. The performance of Dr. PCR was assessed using reference and clinical materials. Precision, linearity, and correlation with qRT-PCR were evaluated. MRD levels detected by Dr. PCR were compared to qRT-PCR, and practical advantages were investigated. Dr. PCR detected MRD up to 0.0032%IS (MR4.5) with excellent precision and linearity and showed strong correlation with qRT-PCR results. Notably, Dr. PCR identified higher levels of MRD in 12.7% (29/229) of patients compared to qRT-PCR, including six cases of MR4, which is a critical level for TKI discontinuation. Dr. PCR also allowed for sufficient ABL1 copies in all cases, while qRT-PCR necessitated multiple repeat tests in 3.5% (8/229) of cases. Our study provides evidences supporting the clinical application of Dr. PCR as a rapid and efficient method for assessing MRD in CML patients under the current treatment regimen." @default.
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- W4386003020 date "2023-08-01" @default.
- W4386003020 modified "2023-10-12" @default.
- W4386003020 title "WITHDRAWN: A novel digital PCR assay targeting major BCR::ABL1 fusion transcripts" @default.
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- W4386003020 doi "https://doi.org/10.1016/j.plabm.2023.e00331" @default.
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