FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386003022> ?p ?o ?g. }

• W4386003022 endingPage "113291" @default.
• W4386003022 startingPage "113291" @default.
• W4386003022 abstract "Seek new candidate prognostic markers for neuroblastoma outcome, relapse or progression.In this multicentre and retrospective study, Random Forests coupled with recursive feature elimination techniques were applied to electronic records (55 clinical features) of 3034 neuroblastoma patients. To assess model performance and feature importance, dataset was split into a training set (80%) and a test set (20%).In the test set, the mean Matthews correlation coefficient for the Random Forests models was greater than 0.46. Feature importance analysis revealed that, together with maximum response to first-line treatment (D_MAX_RESP), time to maximum response to first-line treatment (TIME_MAX_RESP.days) is a relevant predictor of both patients' outcome and relapseprogression. We showed the prognostic value of the max response to first-line treatment in clinically relevant subsets of high-, intermediate-, and low-risk patients for both overall and relapse-free survival (Log-rank p-value<0.0001). In high-risk patients older than 18 months and stage 4 tumour achieving a complete response or very good partial response, patients who exhibited a D_MAX_RESP greater than 9 months showed a better prognosis with respect to patients achieving D_MAX_RESP earlier than 9 months (overall survival): hazard ratio 3.3 95% confidence interval 1.8-5.9, Log-rank p-value p < 0.0001; relapse-free survival: 3.2 95%CI 1.8-5.6, Log-rank p-value p < 0.0001).Our findings evidence the emerging role of the TIME_MAX_RESP.days in addition to the D_MAX_RESP as relevant predictors of outcome and relapseprogression in neuroblastoma with potential clinical impact on the management and treatment of patients." @default.
• W4386003022 created "2023-08-20" @default.
• W4386003022 creator A5011556172 @default.
• W4386003022 creator A5036969722 @default.
• W4386003022 creator A5037623587 @default.
• W4386003022 creator A5057833674 @default.
• W4386003022 creator A5074834398 @default.
• W4386003022 creator A5079494146 @default.
• W4386003022 date "2023-11-01" @default.
• W4386003022 modified "2023-10-17" @default.
• W4386003022 title "Computational intelligence analysis of high-risk neuroblastoma patient health records reveals time to maximum response as one of the most relevant factors for outcome prediction" @default.
• W4386003022 cites W1849812492 @default.
• W4386003022 cites W1897633113 @default.
• W4386003022 cites W1966935624 @default.
• W4386003022 cites W2023587649 @default.
• W4386003022 cites W2085395466 @default.
• W4386003022 cites W2096398040 @default.
• W4386003022 cites W2109553965 @default.
• W4386003022 cites W2117018900 @default.
• W4386003022 cites W2128560053 @default.
• W4386003022 cites W2129963666 @default.
• W4386003022 cites W2138216545 @default.
• W4386003022 cites W2152420890 @default.
• W4386003022 cites W2171696371 @default.
• W4386003022 cites W2224014377 @default.
• W4386003022 cites W2264275593 @default.
• W4386003022 cites W2404130089 @default.
• W4386003022 cites W2528870126 @default.
• W4386003022 cites W2602979636 @default.
• W4386003022 cites W2736848882 @default.
• W4386003022 cites W2793376960 @default.
• W4386003022 cites W2803731073 @default.
• W4386003022 cites W2806796399 @default.
• W4386003022 cites W2889489530 @default.
• W4386003022 cites W2891375035 @default.
• W4386003022 cites W2900463817 @default.
• W4386003022 cites W2911964244 @default.
• W4386003022 cites W2917527391 @default.
• W4386003022 cites W2960341078 @default.
• W4386003022 cites W2975612929 @default.
• W4386003022 cites W3004101682 @default.
• W4386003022 cites W3076622137 @default.
• W4386003022 cites W3094519891 @default.
• W4386003022 cites W3095833143 @default.
• W4386003022 cites W3096067766 @default.
• W4386003022 cites W3103778988 @default.
• W4386003022 cites W3125960260 @default.
• W4386003022 cites W3126232929 @default.
• W4386003022 cites W3128825412 @default.
• W4386003022 cites W3139397034 @default.
• W4386003022 cites W3140310152 @default.
• W4386003022 cites W3143381390 @default.
• W4386003022 cites W3164919471 @default.
• W4386003022 cites W3172444956 @default.
• W4386003022 cites W3173686793 @default.
• W4386003022 cites W3184057816 @default.
• W4386003022 cites W3202740995 @default.
• W4386003022 cites W4210424404 @default.
• W4386003022 cites W4210452247 @default.
• W4386003022 cites W4241801284 @default.
• W4386003022 cites W4281486974 @default.
• W4386003022 cites W4321214126 @default.
• W4386003022 doi "https://doi.org/10.1016/j.ejca.2023.113291" @default.
• W4386003022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37708628" @default.
• W4386003022 hasPublicationYear "2023" @default.
• W4386003022 type Work @default.
• W4386003022 citedByCount "0" @default.
• W4386003022 crossrefType "journal-article" @default.
• W4386003022 hasAuthorship W4386003022A5011556172 @default.
• W4386003022 hasAuthorship W4386003022A5036969722 @default.
• W4386003022 hasAuthorship W4386003022A5037623587 @default.
• W4386003022 hasAuthorship W4386003022A5057833674 @default.
• W4386003022 hasAuthorship W4386003022A5074834398 @default.
• W4386003022 hasAuthorship W4386003022A5079494146 @default.
• W4386003022 hasBestOaLocation W43860030221 @default.
• W4386003022 hasConcept C10515644 @default.
• W4386003022 hasConcept C126322002 @default.
• W4386003022 hasConcept C137345334 @default.
• W4386003022 hasConcept C143998085 @default.
• W4386003022 hasConcept C144237770 @default.
• W4386003022 hasConcept C148220186 @default.
• W4386003022 hasConcept C154945302 @default.
• W4386003022 hasConcept C167135981 @default.
• W4386003022 hasConcept C169258074 @default.
• W4386003022 hasConcept C207103383 @default.
• W4386003022 hasConcept C2776715637 @default.
• W4386003022 hasConcept C2780739268 @default.
• W4386003022 hasConcept C3019894029 @default.
• W4386003022 hasConcept C33923547 @default.
• W4386003022 hasConcept C41008148 @default.
• W4386003022 hasConcept C44249647 @default.
• W4386003022 hasConcept C50382708 @default.
• W4386003022 hasConcept C54355233 @default.
• W4386003022 hasConcept C66339696 @default.
• W4386003022 hasConcept C71924100 @default.
• W4386003022 hasConcept C81885089 @default.
• W4386003022 hasConcept C86803240 @default.
• W4386003022 hasConceptScore W4386003022C10515644 @default.

• next