Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386003043> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4386003043 endingPage "e18779" @default.
- W4386003043 startingPage "e18779" @default.
- W4386003043 abstract "ObjectiveBreast cancer is one of the most prevalent cancers in females worldwide and is one of the leading causes of cancer death and disability in women. Multiple therapies have been applied to breast cancer treatment; however, the long-term survival rate remains low. Although cisplatin has been widely utilized for cancer therapy, chemoresistance still influences the outcome.MethodsAfter collecting the breast cancer cell line MDA-MB-231 treated with or without cisplatin and sample information from The Cancer Genome Atlas Program (TCGA), we screened out their common parameters and influences on the prognoses of patients' potential targets. Surgical excisional tissue sections of patients with breast cancer who were admitted and treated in the Department of Breast and Thyroid Surgery, Liuzhou People's Hospital from 2017 to 2020 was collected and follow up. After a series of assays combined with clinical information, we tested the reliability of the target.ResultsWe found that a high expression level of ZNF268 in breast cancer cell lines significantly enhances the sensitivity to cisplatin, contrary to the effects of low expression. Furthermore, a significantly worse prognosis was observed in patients with a high expression of ZNF268 after cisplatin chemotherapy.ConclusionThe expression level of ZNF268 in breast cancer patients after cisplatin chemotherapy may become a potential target to predict the chemoresistance of patients to cisplatin. This study provides a novel idea for improving breast cancer treatment and survival rates." @default.
- W4386003043 created "2023-08-20" @default.
- W4386003043 creator A5001993571 @default.
- W4386003043 creator A5009000189 @default.
- W4386003043 creator A5016300018 @default.
- W4386003043 creator A5034388034 @default.
- W4386003043 creator A5046422245 @default.
- W4386003043 creator A5050599872 @default.
- W4386003043 creator A5054567757 @default.
- W4386003043 creator A5083999397 @default.
- W4386003043 date "2023-08-01" @default.
- W4386003043 modified "2023-10-07" @default.
- W4386003043 title "The Expression of ZNF268 and Its Role in The Cisplatin-based Chemoresistance of Breast Cancer" @default.
- W4386003043 cites W1984591407 @default.
- W4386003043 cites W1995147894 @default.
- W4386003043 cites W2017159901 @default.
- W4386003043 cites W2050707922 @default.
- W4386003043 cites W2050761481 @default.
- W4386003043 cites W2052857809 @default.
- W4386003043 cites W2060580840 @default.
- W4386003043 cites W2086223209 @default.
- W4386003043 cites W2101301578 @default.
- W4386003043 cites W2114104545 @default.
- W4386003043 cites W2130116522 @default.
- W4386003043 cites W2138453480 @default.
- W4386003043 cites W2144899183 @default.
- W4386003043 cites W2155460954 @default.
- W4386003043 cites W2466314544 @default.
- W4386003043 cites W2507880739 @default.
- W4386003043 cites W2560322684 @default.
- W4386003043 cites W2742282063 @default.
- W4386003043 cites W2765224588 @default.
- W4386003043 cites W2937766145 @default.
- W4386003043 cites W2951071083 @default.
- W4386003043 cites W2995674978 @default.
- W4386003043 cites W3005700710 @default.
- W4386003043 cites W3023752815 @default.
- W4386003043 cites W3027286012 @default.
- W4386003043 cites W3111963281 @default.
- W4386003043 cites W3181820648 @default.
- W4386003043 cites W3195237310 @default.
- W4386003043 cites W4211005384 @default.
- W4386003043 cites W4223454235 @default.
- W4386003043 cites W4241872665 @default.
- W4386003043 cites W4307884879 @default.
- W4386003043 cites W4309164324 @default.
- W4386003043 doi "https://doi.org/10.1016/j.heliyon.2023.e18779" @default.
- W4386003043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37664731" @default.
- W4386003043 hasPublicationYear "2023" @default.
- W4386003043 type Work @default.
- W4386003043 citedByCount "0" @default.
- W4386003043 crossrefType "journal-article" @default.
- W4386003043 hasAuthorship W4386003043A5001993571 @default.
- W4386003043 hasAuthorship W4386003043A5009000189 @default.
- W4386003043 hasAuthorship W4386003043A5016300018 @default.
- W4386003043 hasAuthorship W4386003043A5034388034 @default.
- W4386003043 hasAuthorship W4386003043A5046422245 @default.
- W4386003043 hasAuthorship W4386003043A5050599872 @default.
- W4386003043 hasAuthorship W4386003043A5054567757 @default.
- W4386003043 hasAuthorship W4386003043A5083999397 @default.
- W4386003043 hasBestOaLocation W43860030431 @default.
- W4386003043 hasConcept C121608353 @default.
- W4386003043 hasConcept C126322002 @default.
- W4386003043 hasConcept C143998085 @default.
- W4386003043 hasConcept C2776694085 @default.
- W4386003043 hasConcept C2778239845 @default.
- W4386003043 hasConcept C530470458 @default.
- W4386003043 hasConcept C71924100 @default.
- W4386003043 hasConceptScore W4386003043C121608353 @default.
- W4386003043 hasConceptScore W4386003043C126322002 @default.
- W4386003043 hasConceptScore W4386003043C143998085 @default.
- W4386003043 hasConceptScore W4386003043C2776694085 @default.
- W4386003043 hasConceptScore W4386003043C2778239845 @default.
- W4386003043 hasConceptScore W4386003043C530470458 @default.
- W4386003043 hasConceptScore W4386003043C71924100 @default.
- W4386003043 hasIssue "8" @default.
- W4386003043 hasLocation W43860030431 @default.
- W4386003043 hasLocation W43860030432 @default.
- W4386003043 hasLocation W43860030433 @default.
- W4386003043 hasOpenAccess W4386003043 @default.
- W4386003043 hasPrimaryLocation W43860030431 @default.
- W4386003043 hasRelatedWork W1971929983 @default.
- W4386003043 hasRelatedWork W2021865845 @default.
- W4386003043 hasRelatedWork W2091461259 @default.
- W4386003043 hasRelatedWork W2149068418 @default.
- W4386003043 hasRelatedWork W2406596433 @default.
- W4386003043 hasRelatedWork W2406608798 @default.
- W4386003043 hasRelatedWork W2460036924 @default.
- W4386003043 hasRelatedWork W2557359331 @default.
- W4386003043 hasRelatedWork W2892677547 @default.
- W4386003043 hasRelatedWork W3120025342 @default.
- W4386003043 hasVolume "9" @default.
- W4386003043 isParatext "false" @default.
- W4386003043 isRetracted "false" @default.
- W4386003043 workType "article" @default.