FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386003188> ?p ?o ?g. }

• W4386003188 endingPage "e001726" @default.
• W4386003188 startingPage "e001726" @default.
• W4386003188 abstract "Background Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia. Moraxella catarrhalis is one of the most common bacterial causes of infectious exacerbation in COPD. Currently, to our knowledge, no studies have investigated if ICS increases the risk of lower respiratory tract infection with M. catarrhalis in patients with COPD. Objective To investigate if accumulated ICS use in patients with COPD, is associated with a dose-dependent risk of infection with M. catarrhalis . Methods This observational cohort study included 18 870 persons with COPD who were registered in The Danish Register of COPD. Linkage to several nationwide registries was performed. Exposure to ICS was determined by identifying all prescriptions for ICS, redeemed within 365 days prior to study entry. Main outcome was a lower respiratory tract sample positive for M. catarrhalis . For the main analysis, a Cox multivariate regression model was used. We defined clinical infection as admission to hospital and/or a redeemed prescription for a relevant antibiotic, within 7 days prior to 14 days after the sample was obtained. Results We found an increased, dose-dependent, risk of a lower respiratory tract sample with M. catarrhalis among patients who used ICS, compared with non-users. For low and moderate doses of ICS HR was 1.65 (95% CI 1.19 to 2.30, p=0.003) and 1.82 (95% CI 1.32 to 2.51, p=0.0002), respectively. In the group of patients with highest ICS exposure, the HR of M. catarrhalis was 2.80 (95% CI 2.06 to 3.82, p<0.0001). Results remained stable in sensitivity analyses. 87% of patients fulfilled the criteria for clinical infection, and results remained unchanged in this population. Conclusion Our study shows a dose-dependent increased risk of infection with M. catarrhalis associated to ICS exposure." @default.
• W4386003188 created "2023-08-20" @default.
• W4386003188 creator A5001686467 @default.
• W4386003188 creator A5002472471 @default.
• W4386003188 creator A5007573133 @default.
• W4386003188 creator A5022531645 @default.
• W4386003188 creator A5024242782 @default.
• W4386003188 creator A5042553258 @default.
• W4386003188 creator A5055755337 @default.
• W4386003188 creator A5087894282 @default.
• W4386003188 date "2023-08-01" @default.
• W4386003188 modified "2023-09-26" @default.
• W4386003188 title "Inhaled corticosteroids and risk of lower respiratory tract infection with<i>Moraxella catarrhalis</i>in patients with chronic obstructive pulmonary disease" @default.
• W4386003188 cites W1861036421 @default.
• W4386003188 cites W1969602318 @default.
• W4386003188 cites W1983772324 @default.
• W4386003188 cites W2029803251 @default.
• W4386003188 cites W2048470090 @default.
• W4386003188 cites W2068420419 @default.
• W4386003188 cites W2080276371 @default.
• W4386003188 cites W2102924526 @default.
• W4386003188 cites W2129558427 @default.
• W4386003188 cites W2139192099 @default.
• W4386003188 cites W2142724633 @default.
• W4386003188 cites W2324038222 @default.
• W4386003188 cites W2544185954 @default.
• W4386003188 cites W2587490518 @default.
• W4386003188 cites W2763841590 @default.
• W4386003188 cites W3011621519 @default.
• W4386003188 cites W3108245859 @default.
• W4386003188 cites W3176248074 @default.
• W4386003188 cites W3176486399 @default.
• W4386003188 cites W3196265097 @default.
• W4386003188 cites W3202835723 @default.
• W4386003188 cites W4283215277 @default.
• W4386003188 cites W4284693614 @default.
• W4386003188 cites W4313244480 @default.
• W4386003188 doi "https://doi.org/10.1136/bmjresp-2023-001726" @default.
• W4386003188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597970" @default.
• W4386003188 hasPublicationYear "2023" @default.
• W4386003188 type Work @default.
• W4386003188 citedByCount "0" @default.
• W4386003188 crossrefType "journal-article" @default.
• W4386003188 hasAuthorship W4386003188A5001686467 @default.
• W4386003188 hasAuthorship W4386003188A5002472471 @default.
• W4386003188 hasAuthorship W4386003188A5007573133 @default.
• W4386003188 hasAuthorship W4386003188A5022531645 @default.
• W4386003188 hasAuthorship W4386003188A5024242782 @default.
• W4386003188 hasAuthorship W4386003188A5042553258 @default.
• W4386003188 hasAuthorship W4386003188A5055755337 @default.
• W4386003188 hasAuthorship W4386003188A5087894282 @default.
• W4386003188 hasBestOaLocation W43860031881 @default.
• W4386003188 hasConcept C126322002 @default.
• W4386003188 hasConcept C2776012195 @default.
• W4386003188 hasConcept C2776399701 @default.
• W4386003188 hasConcept C2776551000 @default.
• W4386003188 hasConcept C2776780178 @default.
• W4386003188 hasConcept C2776925733 @default.
• W4386003188 hasConcept C2777014857 @default.
• W4386003188 hasConcept C2777914695 @default.
• W4386003188 hasConcept C2779644171 @default.
• W4386003188 hasConcept C2910443534 @default.
• W4386003188 hasConcept C501593827 @default.
• W4386003188 hasConcept C534529494 @default.
• W4386003188 hasConcept C71924100 @default.
• W4386003188 hasConcept C86803240 @default.
• W4386003188 hasConcept C89423630 @default.
• W4386003188 hasConceptScore W4386003188C126322002 @default.
• W4386003188 hasConceptScore W4386003188C2776012195 @default.
• W4386003188 hasConceptScore W4386003188C2776399701 @default.
• W4386003188 hasConceptScore W4386003188C2776551000 @default.
• W4386003188 hasConceptScore W4386003188C2776780178 @default.
• W4386003188 hasConceptScore W4386003188C2776925733 @default.
• W4386003188 hasConceptScore W4386003188C2777014857 @default.
• W4386003188 hasConceptScore W4386003188C2777914695 @default.
• W4386003188 hasConceptScore W4386003188C2779644171 @default.
• W4386003188 hasConceptScore W4386003188C2910443534 @default.
• W4386003188 hasConceptScore W4386003188C501593827 @default.
• W4386003188 hasConceptScore W4386003188C534529494 @default.
• W4386003188 hasConceptScore W4386003188C71924100 @default.
• W4386003188 hasConceptScore W4386003188C86803240 @default.
• W4386003188 hasConceptScore W4386003188C89423630 @default.
• W4386003188 hasFunder F4320322436 @default.
• W4386003188 hasIssue "1" @default.
• W4386003188 hasLocation W43860031881 @default.
• W4386003188 hasLocation W43860031882 @default.
• W4386003188 hasOpenAccess W4386003188 @default.
• W4386003188 hasPrimaryLocation W43860031881 @default.
• W4386003188 hasRelatedWork W2040670775 @default.
• W4386003188 hasRelatedWork W2098621843 @default.
• W4386003188 hasRelatedWork W2172696029 @default.
• W4386003188 hasRelatedWork W2415775725 @default.
• W4386003188 hasRelatedWork W2517994609 @default.
• W4386003188 hasRelatedWork W2533225085 @default.
• W4386003188 hasRelatedWork W4205779314 @default.
• W4386003188 hasRelatedWork W4362505920 @default.
• W4386003188 hasRelatedWork W2189162426 @default.
• W4386003188 hasRelatedWork W247150622 @default.

• next