FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386003193> ?p ?o ?g. }

• W4386003193 endingPage "100654" @default.
• W4386003193 startingPage "100654" @default.
• W4386003193 abstract "Comparative oncology is an understudied field of science. We are far from understanding the key mechanisms behind Peto's paradox, i.e. understanding how long-lived and large animals are not subject to a higher cancer burden despite the longer exposure time to mutations and the larger number of cells exposed. In this work we investigated the scientific evidence on such mechanisms through a systematic mini-review of the literature about the relation of longevity and/or large body mass with physiological, genetic or environmental traits among mammalian species. More than forty thousand articles were retrieved from three repositories and 383 of them were screened using an active-learning-based tool. Of those, 36 articles on longevity and 37 on body mass were selected for the review. Such articles were examined focusing on: number and type of species considered, statistical methods used, traits investigated, and observed relationship with longevity and/or body mass. Where applicable, the traits investigated were matched with one or more hallmarks of cancer. We obtained a list of potential candidate traits to explain the Peto's paradox, related to replicative immortality, cells senescence, genome instability and mutations, proliferative signaling, growth suppression evasion and cells resistance to death. Our investigation suggests that different strategies have been followed to prevent cancer in large and long-lived species. The large number of papers retrieved emphasizes that more studies can be launched in the future, using more efficient analytical approaches, to comprehensively evaluate the convergent biological mechanisms essential for acquiring longevity and large body mass without increasing cancer risk." @default.
• W4386003193 created "2023-08-20" @default.
• W4386003193 creator A5002941782 @default.
• W4386003193 creator A5003560823 @default.
• W4386003193 creator A5005124809 @default.
• W4386003193 creator A5021899768 @default.
• W4386003193 creator A5026543382 @default.
• W4386003193 creator A5038670151 @default.
• W4386003193 creator A5045380913 @default.
• W4386003193 date "2023-08-01" @default.
• W4386003193 modified "2023-10-12" @default.
• W4386003193 title "Peto's paradox: Nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic mini-review" @default.
• W4386003193 cites W1999108035 @default.
• W4386003193 cites W2007114580 @default.
• W4386003193 cites W2013410948 @default.
• W4386003193 cites W2020046400 @default.
• W4386003193 cites W2030389371 @default.
• W4386003193 cites W2032220905 @default.
• W4386003193 cites W2033344778 @default.
• W4386003193 cites W2034269086 @default.
• W4386003193 cites W2040466227 @default.
• W4386003193 cites W2085970707 @default.
• W4386003193 cites W2098369446 @default.
• W4386003193 cites W2098782851 @default.
• W4386003193 cites W2117066938 @default.
• W4386003193 cites W2117516032 @default.
• W4386003193 cites W2117692326 @default.
• W4386003193 cites W2118887253 @default.
• W4386003193 cites W2130609411 @default.
• W4386003193 cites W2144551660 @default.
• W4386003193 cites W2145955179 @default.
• W4386003193 cites W2146713153 @default.
• W4386003193 cites W2171074069 @default.
• W4386003193 cites W2344419622 @default.
• W4386003193 cites W2515001268 @default.
• W4386003193 cites W2552812120 @default.
• W4386003193 cites W2582227691 @default.
• W4386003193 cites W2620841069 @default.
• W4386003193 cites W2791718384 @default.
• W4386003193 cites W2911353980 @default.
• W4386003193 cites W2937386865 @default.
• W4386003193 cites W3001327596 @default.
• W4386003193 cites W3004507471 @default.
• W4386003193 cites W3021405428 @default.
• W4386003193 cites W3109900926 @default.
• W4386003193 cites W3118615836 @default.
• W4386003193 cites W3128349626 @default.
• W4386003193 cites W3133775963 @default.
• W4386003193 cites W3170602141 @default.
• W4386003193 cites W3209550321 @default.
• W4386003193 cites W4200048313 @default.
• W4386003193 cites W4225246272 @default.
• W4386003193 cites W4225529913 @default.
• W4386003193 cites W4311792043 @default.
• W4386003193 cites W4368340891 @default.
• W4386003193 doi "https://doi.org/10.1016/j.bj.2023.100654" @default.
• W4386003193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37604250" @default.
• W4386003193 hasPublicationYear "2023" @default.
• W4386003193 type Work @default.
• W4386003193 citedByCount "0" @default.
• W4386003193 crossrefType "journal-article" @default.
• W4386003193 hasAuthorship W4386003193A5002941782 @default.
• W4386003193 hasAuthorship W4386003193A5003560823 @default.
• W4386003193 hasAuthorship W4386003193A5005124809 @default.
• W4386003193 hasAuthorship W4386003193A5021899768 @default.
• W4386003193 hasAuthorship W4386003193A5026543382 @default.
• W4386003193 hasAuthorship W4386003193A5038670151 @default.
• W4386003193 hasAuthorship W4386003193A5045380913 @default.
• W4386003193 hasBestOaLocation W43860031931 @default.
• W4386003193 hasConcept C121608353 @default.
• W4386003193 hasConcept C2776759703 @default.
• W4386003193 hasConcept C2779227060 @default.
• W4386003193 hasConcept C54355233 @default.
• W4386003193 hasConcept C78458016 @default.
• W4386003193 hasConcept C86803240 @default.
• W4386003193 hasConceptScore W4386003193C121608353 @default.
• W4386003193 hasConceptScore W4386003193C2776759703 @default.
• W4386003193 hasConceptScore W4386003193C2779227060 @default.
• W4386003193 hasConceptScore W4386003193C54355233 @default.
• W4386003193 hasConceptScore W4386003193C78458016 @default.
• W4386003193 hasConceptScore W4386003193C86803240 @default.
• W4386003193 hasLocation W43860031931 @default.
• W4386003193 hasLocation W43860031932 @default.
• W4386003193 hasOpenAccess W4386003193 @default.
• W4386003193 hasPrimaryLocation W43860031931 @default.
• W4386003193 hasRelatedWork W162699494 @default.
• W4386003193 hasRelatedWork W2092572701 @default.
• W4386003193 hasRelatedWork W2349210760 @default.
• W4386003193 hasRelatedWork W2949394179 @default.
• W4386003193 hasRelatedWork W3128385226 @default.
• W4386003193 hasRelatedWork W3164976623 @default.
• W4386003193 hasRelatedWork W4205374381 @default.
• W4386003193 hasRelatedWork W4245275599 @default.
• W4386003193 hasRelatedWork W4300658084 @default.
• W4386003193 hasRelatedWork W561220276 @default.
• W4386003193 isParatext "false" @default.
• W4386003193 isRetracted "false" @default.
• W4386003193 workType "article" @default.