Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386003372> ?p ?o ?g. }
- W4386003372 endingPage "102199" @default.
- W4386003372 startingPage "102199" @default.
- W4386003372 abstract "The study aimed to evaluate the differentiation ability of intravitreally injected rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) to retinal ganglion-like cells in a polystyrene microsphere induced rat glaucoma model. The glaucoma rat model was generated via intracameral injection of 7 microliter polystyrene microspheres. Green fluorescence protein-labeled (GFP) rBM-MSCs were transplanted intravitreally at or after induction of ocular hypertension (OHT), depending on the groups. By the end of the fourth week, flat-mount retinal dissection was performed, and labeled against Brn3a, CD90, GFAP, CD11b, Vimentin, and localization of GFP positive rBM-MSCs was used for evaluation through immunofluorescence staining and to count differentiated retinal cells by flow cytometry. From 34 male Wistar albino rats, 56 eyes were investigated. Flow cytometry revealed significantly increased CD90 and Brn3a positive cells in glaucoma induced and with rBM-MSC injected groups compared to control(P = 0.006 and P = 0.003 respectively), sham-operated (P = 0.007 and P < 0.001 respectively), and only rBM-MSCs injected groups (P = 0.002 and P = 0.009 respectively). Immunofluorescence microscopy revealed differentiation of GFP labeled stem cells to various retinal cells, including ganglion-like cells. rBM-MSCs were observable in ganglion cells, inner and outer nuclear retinal layers in rBM-MSCs injected eyes. Intravitreally transplanted rBM-MSCs differentiated into retinal cells, including ganglion-like cells, which successfully created a glaucoma model damaged with polystyrene microspheres. Promisingly, MSCs may have a role in neuro-protection and neuro-regeneration treatment of glaucoma in the future." @default.
- W4386003372 created "2023-08-20" @default.
- W4386003372 creator A5003679277 @default.
- W4386003372 creator A5009308179 @default.
- W4386003372 creator A5026314491 @default.
- W4386003372 creator A5041778364 @default.
- W4386003372 creator A5043072964 @default.
- W4386003372 creator A5051927006 @default.
- W4386003372 creator A5060602118 @default.
- W4386003372 creator A5078339829 @default.
- W4386003372 creator A5078376649 @default.
- W4386003372 date "2023-10-01" @default.
- W4386003372 modified "2023-10-12" @default.
- W4386003372 title "Mesenchymal Stem Cells Differentiate to Retinal Ganglion-Like Cells in Rat Glaucoma Model Induced by Polystyrene Microspheres" @default.
- W4386003372 cites W1535983901 @default.
- W4386003372 cites W1977607105 @default.
- W4386003372 cites W1982606894 @default.
- W4386003372 cites W1985229106 @default.
- W4386003372 cites W1987421719 @default.
- W4386003372 cites W1989559754 @default.
- W4386003372 cites W1991536078 @default.
- W4386003372 cites W2005174791 @default.
- W4386003372 cites W2007007498 @default.
- W4386003372 cites W2007773129 @default.
- W4386003372 cites W2012821843 @default.
- W4386003372 cites W2046612114 @default.
- W4386003372 cites W2051987080 @default.
- W4386003372 cites W2056586676 @default.
- W4386003372 cites W2075984099 @default.
- W4386003372 cites W2078684091 @default.
- W4386003372 cites W2085097624 @default.
- W4386003372 cites W2087338812 @default.
- W4386003372 cites W2089592211 @default.
- W4386003372 cites W2105313624 @default.
- W4386003372 cites W2106117542 @default.
- W4386003372 cites W2106647511 @default.
- W4386003372 cites W2119220330 @default.
- W4386003372 cites W2122265985 @default.
- W4386003372 cites W2168433596 @default.
- W4386003372 cites W2171557224 @default.
- W4386003372 cites W2317289339 @default.
- W4386003372 cites W2566652846 @default.
- W4386003372 cites W2773198711 @default.
- W4386003372 cites W2789108136 @default.
- W4386003372 cites W2794100252 @default.
- W4386003372 cites W2890888323 @default.
- W4386003372 cites W2977196591 @default.
- W4386003372 cites W3006867577 @default.
- W4386003372 cites W3021404309 @default.
- W4386003372 cites W3029964532 @default.
- W4386003372 cites W3039185250 @default.
- W4386003372 cites W3048435983 @default.
- W4386003372 cites W3130705124 @default.
- W4386003372 cites W3153638131 @default.
- W4386003372 cites W816479943 @default.
- W4386003372 doi "https://doi.org/10.1016/j.tice.2023.102199" @default.
- W4386003372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37633122" @default.
- W4386003372 hasPublicationYear "2023" @default.
- W4386003372 type Work @default.
- W4386003372 citedByCount "0" @default.
- W4386003372 crossrefType "journal-article" @default.
- W4386003372 hasAuthorship W4386003372A5003679277 @default.
- W4386003372 hasAuthorship W4386003372A5009308179 @default.
- W4386003372 hasAuthorship W4386003372A5026314491 @default.
- W4386003372 hasAuthorship W4386003372A5041778364 @default.
- W4386003372 hasAuthorship W4386003372A5043072964 @default.
- W4386003372 hasAuthorship W4386003372A5051927006 @default.
- W4386003372 hasAuthorship W4386003372A5060602118 @default.
- W4386003372 hasAuthorship W4386003372A5078339829 @default.
- W4386003372 hasAuthorship W4386003372A5078376649 @default.
- W4386003372 hasConcept C10205521 @default.
- W4386003372 hasConcept C105702510 @default.
- W4386003372 hasConcept C116716535 @default.
- W4386003372 hasConcept C142724271 @default.
- W4386003372 hasConcept C153911025 @default.
- W4386003372 hasConcept C169760540 @default.
- W4386003372 hasConcept C198826908 @default.
- W4386003372 hasConcept C2777093970 @default.
- W4386003372 hasConcept C2778527774 @default.
- W4386003372 hasConcept C2780827179 @default.
- W4386003372 hasConcept C28328180 @default.
- W4386003372 hasConcept C553184892 @default.
- W4386003372 hasConcept C55493867 @default.
- W4386003372 hasConcept C71924100 @default.
- W4386003372 hasConcept C86803240 @default.
- W4386003372 hasConcept C95444343 @default.
- W4386003372 hasConceptScore W4386003372C10205521 @default.
- W4386003372 hasConceptScore W4386003372C105702510 @default.
- W4386003372 hasConceptScore W4386003372C116716535 @default.
- W4386003372 hasConceptScore W4386003372C142724271 @default.
- W4386003372 hasConceptScore W4386003372C153911025 @default.
- W4386003372 hasConceptScore W4386003372C169760540 @default.
- W4386003372 hasConceptScore W4386003372C198826908 @default.
- W4386003372 hasConceptScore W4386003372C2777093970 @default.
- W4386003372 hasConceptScore W4386003372C2778527774 @default.
- W4386003372 hasConceptScore W4386003372C2780827179 @default.
- W4386003372 hasConceptScore W4386003372C28328180 @default.
- W4386003372 hasConceptScore W4386003372C553184892 @default.