Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386005027> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4386005027 endingPage "629" @default.
- W4386005027 startingPage "629" @default.
- W4386005027 abstract "Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects." @default.
- W4386005027 created "2023-08-20" @default.
- W4386005027 creator A5000660004 @default.
- W4386005027 creator A5086089480 @default.
- W4386005027 creator A5088893132 @default.
- W4386005027 date "2023-01-01" @default.
- W4386005027 modified "2023-10-12" @default.
- W4386005027 title "Evaluation of the vasorelaxant effect of Sugammadex on the arterial smooth muscle in rats" @default.
- W4386005027 doi "https://doi.org/10.5455/medscience.2023.06.092" @default.
- W4386005027 hasPublicationYear "2023" @default.
- W4386005027 type Work @default.
- W4386005027 citedByCount "0" @default.
- W4386005027 crossrefType "journal-article" @default.
- W4386005027 hasAuthorship W4386005027A5000660004 @default.
- W4386005027 hasAuthorship W4386005027A5086089480 @default.
- W4386005027 hasAuthorship W4386005027A5088893132 @default.
- W4386005027 hasBestOaLocation W43860050271 @default.
- W4386005027 hasConcept C126322002 @default.
- W4386005027 hasConcept C141071460 @default.
- W4386005027 hasConcept C163415756 @default.
- W4386005027 hasConcept C2776277131 @default.
- W4386005027 hasConcept C2776864027 @default.
- W4386005027 hasConcept C2776988050 @default.
- W4386005027 hasConcept C2777411258 @default.
- W4386005027 hasConcept C2777952589 @default.
- W4386005027 hasConcept C2778560516 @default.
- W4386005027 hasConcept C2779980429 @default.
- W4386005027 hasConcept C2992204568 @default.
- W4386005027 hasConcept C42219234 @default.
- W4386005027 hasConcept C71924100 @default.
- W4386005027 hasConcept C84393581 @default.
- W4386005027 hasConceptScore W4386005027C126322002 @default.
- W4386005027 hasConceptScore W4386005027C141071460 @default.
- W4386005027 hasConceptScore W4386005027C163415756 @default.
- W4386005027 hasConceptScore W4386005027C2776277131 @default.
- W4386005027 hasConceptScore W4386005027C2776864027 @default.
- W4386005027 hasConceptScore W4386005027C2776988050 @default.
- W4386005027 hasConceptScore W4386005027C2777411258 @default.
- W4386005027 hasConceptScore W4386005027C2777952589 @default.
- W4386005027 hasConceptScore W4386005027C2778560516 @default.
- W4386005027 hasConceptScore W4386005027C2779980429 @default.
- W4386005027 hasConceptScore W4386005027C2992204568 @default.
- W4386005027 hasConceptScore W4386005027C42219234 @default.
- W4386005027 hasConceptScore W4386005027C71924100 @default.
- W4386005027 hasConceptScore W4386005027C84393581 @default.
- W4386005027 hasIssue "3" @default.
- W4386005027 hasLocation W43860050271 @default.
- W4386005027 hasOpenAccess W4386005027 @default.
- W4386005027 hasPrimaryLocation W43860050271 @default.
- W4386005027 hasRelatedWork W2011765774 @default.
- W4386005027 hasRelatedWork W2072286744 @default.
- W4386005027 hasRelatedWork W2119616474 @default.
- W4386005027 hasRelatedWork W2183218377 @default.
- W4386005027 hasRelatedWork W2317046892 @default.
- W4386005027 hasRelatedWork W2328629217 @default.
- W4386005027 hasRelatedWork W2416776439 @default.
- W4386005027 hasRelatedWork W2550803047 @default.
- W4386005027 hasRelatedWork W4220970122 @default.
- W4386005027 hasRelatedWork W4379525497 @default.
- W4386005027 hasVolume "12" @default.
- W4386005027 isParatext "false" @default.
- W4386005027 isRetracted "false" @default.
- W4386005027 workType "article" @default.