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- W4386005403 abstract "In water breathing fish, neuroepithelial cells located in the gills and innervated by the IXth and Xth cranial nerves appear to be the primary chemoreceptors detecting changes in water CO2 levels and stimulating increases in ventilation frequency and/or amplitude. Receptors sensing changes in arterial blood pH may also be involved in producing similar reflex responses. In air-breathing fish the input from these receptors leads to increases in air breathing rather than gill ventilation when levels of aquatic CO2 rise sufficiently. In lungfish, and also in some other air-breathing fish, central (within the brainstem) CO2/H+ sensitive chemoreceptors also appear to be involved in producing respiratory reflexes. The only CO2/H+ chemoreceptors for which the transduction mechanism has been studied at the cellular level are the neuroepithelial cells within the gills. A subset of these cells is depolarized by CO2 due to the closing of a background K+ channel involving a mechanism that is dependent in part on carbonic anhydrase. In some, but not all, cases this occurs in cells that also respond to changes in O2." @default.
- W4386005403 created "2023-08-20" @default.
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- W4386005403 date "2023-01-01" @default.
- W4386005403 modified "2023-10-12" @default.
- W4386005403 title "The ventilatory response to CO2/H+" @default.
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- W4386005403 doi "https://doi.org/10.1016/b978-0-323-90801-6.00053-7" @default.
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