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- W4386006918 abstract "The investigation on the fruits of Pittosporum elevaticostatum Chang et Yan led to the isolation of two undescribed metabolites (1–2, named pitelevatin A and B) and twelve known ones (3–14), including one phthalide (1), four monoquiterpenoids (2–5), two sesquiterpenoids (6–7), two diterpenoids (8–9), and five phenolic analogues (10–14). The structures of 1 and 2 were elucidated based on spectroscopic methods, including high resolution electrospray ionization mass spectroscopy (HR-ESI-MS), one demension (1D) and 2D nuclear magnetic resonance (NMR), ultraviloet (UV), electronic circular dichroism (ECD) spectra and experimental and calculated specific optical rotation (SOR). Compounds 1–3, 7 and 11 showed significant nitric oxide (NO) production inhibitory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells by inhibiting the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), with IC50 values ranging from 6.35 to 25.75 μM. Western blot analysis confirmed the results above." @default.
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- W4386006918 date "2023-10-01" @default.
- W4386006918 modified "2023-10-07" @default.
- W4386006918 title "Anti-inflammatory metabolites from the fruits of Pittosporum elevaticostatum" @default.
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- W4386006918 doi "https://doi.org/10.1016/j.phytol.2023.08.013" @default.
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