FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386008228> ?p ?o ?g. }

• W4386008228 endingPage "4094" @default.
• W4386008228 startingPage "4091" @default.
• W4386008228 abstract "Abstract S ‐Adenosylmethionine‐dependent methyltransferases (MTs) play a decisive role in the biosynthesis of natural products and in epigenetic processes. MTs catalyze the methylation of heteroatoms and even of carbon atoms, which, in many cases, is a challenging reaction in conventional synthesis. However, C‐MTs are often highly substrate‐specific. Herein, we show that SgvM from Streptomyces griseoviridis features an extended substrate scope with respect to the nucleophile as well as the electrophile. Aside from its physiological substrate 4‐methyl‐2‐oxovalerate, SgvM catalyzes the (di)methylation of pyruvate, 2‐oxobutyrate, 2‐oxovalerate, and phenylpyruvate at the β‐carbon atom. Chiral‐phase HPLC analysis revealed that the methylation of 2‐oxovalerate occurs with R selectivity while the ethylation of 2‐oxobutyrate with S ‐adenosylethionine results in the S enantiomer of 3‐methyl‐2‐oxovalerate. Thus SgvM could be a valuable tool for asymmetric biocatalytic C‐alkylation reactions." @default.
• W4386008228 created "2023-08-20" @default.
• W4386008228 creator A5021353698 @default.
• W4386008228 creator A5022682590 @default.
• W4386008228 creator A5033642685 @default.
• W4386008228 creator A5041617936 @default.
• W4386008228 creator A5068402424 @default.
• W4386008228 date "2017-03-01" @default.
• W4386008228 modified "2023-10-07" @default.
• W4386008228 title "Asymmetric C-Alkylation by the <i>S</i> -Adenosylmethionine-Dependent Methyltransferase SgvM" @default.
• W4386008228 cites W1965585392 @default.
• W4386008228 cites W1977773453 @default.
• W4386008228 cites W1977939709 @default.
• W4386008228 cites W1979796943 @default.
• W4386008228 cites W1989045942 @default.
• W4386008228 cites W1993036877 @default.
• W4386008228 cites W2006728554 @default.
• W4386008228 cites W2039433779 @default.
• W4386008228 cites W2042137812 @default.
• W4386008228 cites W2043299704 @default.
• W4386008228 cites W2045636632 @default.
• W4386008228 cites W2056531025 @default.
• W4386008228 cites W2057325206 @default.
• W4386008228 cites W2062575600 @default.
• W4386008228 cites W2072121748 @default.
• W4386008228 cites W2072124763 @default.
• W4386008228 cites W2097472327 @default.
• W4386008228 cites W2100071542 @default.
• W4386008228 cites W2101650875 @default.
• W4386008228 cites W2110506044 @default.
• W4386008228 cites W2116322925 @default.
• W4386008228 cites W2117596106 @default.
• W4386008228 cites W2121140685 @default.
• W4386008228 cites W2122632516 @default.
• W4386008228 cites W2136391678 @default.
• W4386008228 cites W2141710137 @default.
• W4386008228 cites W2150397781 @default.
• W4386008228 cites W2170225177 @default.
• W4386008228 cites W2287122233 @default.
• W4386008228 cites W2301785266 @default.
• W4386008228 cites W2396643508 @default.
• W4386008228 cites W2462272042 @default.
• W4386008228 cites W4205243700 @default.
• W4386008228 cites W4240845744 @default.
• W4386008228 cites W4243931305 @default.
• W4386008228 doi "https://doi.org/10.1002/ange.201609375" @default.
• W4386008228 hasPublicationYear "2017" @default.
• W4386008228 type Work @default.
• W4386008228 citedByCount "16" @default.
• W4386008228 countsByYear W43860082282017 @default.
• W4386008228 countsByYear W43860082282018 @default.
• W4386008228 countsByYear W43860082282019 @default.
• W4386008228 countsByYear W43860082282020 @default.
• W4386008228 countsByYear W43860082282021 @default.
• W4386008228 countsByYear W43860082282022 @default.
• W4386008228 countsByYear W43860082282023 @default.
• W4386008228 crossrefType "journal-article" @default.
• W4386008228 hasAuthorship W4386008228A5021353698 @default.
• W4386008228 hasAuthorship W4386008228A5022682590 @default.
• W4386008228 hasAuthorship W4386008228A5033642685 @default.
• W4386008228 hasAuthorship W4386008228A5041617936 @default.
• W4386008228 hasAuthorship W4386008228A5068402424 @default.
• W4386008228 hasConcept C146686406 @default.
• W4386008228 hasConcept C161790260 @default.
• W4386008228 hasConcept C164361826 @default.
• W4386008228 hasConcept C178790620 @default.
• W4386008228 hasConcept C178907741 @default.
• W4386008228 hasConcept C185592680 @default.
• W4386008228 hasConcept C18903297 @default.
• W4386008228 hasConcept C20950531 @default.
• W4386008228 hasConcept C2777289219 @default.
• W4386008228 hasConcept C2780378348 @default.
• W4386008228 hasConcept C33288867 @default.
• W4386008228 hasConcept C486523 @default.
• W4386008228 hasConcept C50027330 @default.
• W4386008228 hasConcept C552990157 @default.
• W4386008228 hasConcept C55493867 @default.
• W4386008228 hasConcept C71240020 @default.
• W4386008228 hasConcept C86803240 @default.
• W4386008228 hasConcept C91965660 @default.
• W4386008228 hasConceptScore W4386008228C146686406 @default.
• W4386008228 hasConceptScore W4386008228C161790260 @default.
• W4386008228 hasConceptScore W4386008228C164361826 @default.
• W4386008228 hasConceptScore W4386008228C178790620 @default.
• W4386008228 hasConceptScore W4386008228C178907741 @default.
• W4386008228 hasConceptScore W4386008228C185592680 @default.
• W4386008228 hasConceptScore W4386008228C18903297 @default.
• W4386008228 hasConceptScore W4386008228C20950531 @default.
• W4386008228 hasConceptScore W4386008228C2777289219 @default.
• W4386008228 hasConceptScore W4386008228C2780378348 @default.
• W4386008228 hasConceptScore W4386008228C33288867 @default.
• W4386008228 hasConceptScore W4386008228C486523 @default.
• W4386008228 hasConceptScore W4386008228C50027330 @default.
• W4386008228 hasConceptScore W4386008228C552990157 @default.
• W4386008228 hasConceptScore W4386008228C55493867 @default.
• W4386008228 hasConceptScore W4386008228C71240020 @default.
• W4386008228 hasConceptScore W4386008228C86803240 @default.
• W4386008228 hasConceptScore W4386008228C91965660 @default.

• next