FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386009493> ?p ?o ?g. }

• W4386009493 abstract "The role of cardiac microvascular endothelial cells (CMECs) in diabetic cardiomyopathy is not fully understood. We aimed to investigate whether a glucagon receptor (GCGR) monoclonal antibody (mAb) ameliorated diabetic cardiomyopathy and clarify whether and how CMECs participated in the process.The db/db mice were treated with GCGR mAb or immunoglobulin G (as control) for 4 weeks. Echocardiography was performed to evaluate cardiac function. Immunofluorescent staining was used to determine microvascular density. The proteomic signature in isolated primary CMECs was analyzed by using tandem mass tag-based quantitative proteomic analysis. Some target proteins were verified by using western blot.Compared with db/m mice, cardiac microvascular density and left ventricular diastolic function were significantly reduced in db/db mice, and this reduction was attenuated by GCGR mAb treatment. A total of 199 differentially expressed proteins were upregulated in db/db mice versus db/m mice and downregulated in GCGR mAb-treated db/db mice versus db/db mice. The enrichment analysis demonstrated that fatty acid β-oxidation and mitochondrial fusion were the key pathways. The changes of the related proteins carnitine palmitoyltransferase 1B, optic atrophy type 1, and mitofusin-1 were further verified by using western blot. The levels of these three proteins were upregulated in db/db mice, whereas this upregulation was attenuated by GCGR mAb treatment.GCGR antagonism has a protective effect on CMECs and cardiac diastolic function in diabetic mice, and this beneficial effect may be mediated via inhibiting fatty acid β-oxidation and mitochondrial fusion in CMECs." @default.
• W4386009493 created "2023-08-21" @default.
• W4386009493 creator A5006301048 @default.
• W4386009493 creator A5019872937 @default.
• W4386009493 creator A5026221239 @default.
• W4386009493 creator A5050887292 @default.
• W4386009493 creator A5060087396 @default.
• W4386009493 creator A5081329695 @default.
• W4386009493 creator A5091867277 @default.
• W4386009493 date "2023-08-19" @default.
• W4386009493 modified "2023-10-14" @default.
• W4386009493 title "Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice" @default.
• W4386009493 cites W1987846826 @default.
• W4386009493 cites W1990253071 @default.
• W4386009493 cites W2004356125 @default.
• W4386009493 cites W2008080411 @default.
• W4386009493 cites W2031573979 @default.
• W4386009493 cites W2067940869 @default.
• W4386009493 cites W2079793296 @default.
• W4386009493 cites W2096823131 @default.
• W4386009493 cites W2100188776 @default.
• W4386009493 cites W2109011367 @default.
• W4386009493 cites W2129983555 @default.
• W4386009493 cites W2138936938 @default.
• W4386009493 cites W2146264128 @default.
• W4386009493 cites W2148471604 @default.
• W4386009493 cites W2152578678 @default.
• W4386009493 cites W2163457045 @default.
• W4386009493 cites W2572344066 @default.
• W4386009493 cites W2608631438 @default.
• W4386009493 cites W2626446274 @default.
• W4386009493 cites W2765700591 @default.
• W4386009493 cites W2787153479 @default.
• W4386009493 cites W2910730299 @default.
• W4386009493 cites W2920970731 @default.
• W4386009493 cites W2933979854 @default.
• W4386009493 cites W2939222610 @default.
• W4386009493 cites W2947644232 @default.
• W4386009493 cites W2949481218 @default.
• W4386009493 cites W2950591584 @default.
• W4386009493 cites W2999614741 @default.
• W4386009493 cites W3011226871 @default.
• W4386009493 cites W3020528808 @default.
• W4386009493 cites W3036043714 @default.
• W4386009493 cites W4281947100 @default.
• W4386009493 doi "https://doi.org/10.1111/1753-0407.13458" @default.
• W4386009493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37596940" @default.
• W4386009493 hasPublicationYear "2023" @default.
• W4386009493 type Work @default.
• W4386009493 citedByCount "0" @default.
• W4386009493 crossrefType "journal-article" @default.
• W4386009493 hasAuthorship W4386009493A5006301048 @default.
• W4386009493 hasAuthorship W4386009493A5019872937 @default.
• W4386009493 hasAuthorship W4386009493A5026221239 @default.
• W4386009493 hasAuthorship W4386009493A5050887292 @default.
• W4386009493 hasAuthorship W4386009493A5060087396 @default.
• W4386009493 hasAuthorship W4386009493A5081329695 @default.
• W4386009493 hasAuthorship W4386009493A5091867277 @default.
• W4386009493 hasBestOaLocation W43860094931 @default.
• W4386009493 hasConcept C104317684 @default.
• W4386009493 hasConcept C111566952 @default.
• W4386009493 hasConcept C123894998 @default.
• W4386009493 hasConcept C126322002 @default.
• W4386009493 hasConcept C127561419 @default.
• W4386009493 hasConcept C134018914 @default.
• W4386009493 hasConcept C163950672 @default.
• W4386009493 hasConcept C170493617 @default.
• W4386009493 hasConcept C185592680 @default.
• W4386009493 hasConcept C24586158 @default.
• W4386009493 hasConcept C2776415932 @default.
• W4386009493 hasConcept C2776553924 @default.
• W4386009493 hasConcept C2778198053 @default.
• W4386009493 hasConcept C2778797674 @default.
• W4386009493 hasConcept C40767141 @default.
• W4386009493 hasConcept C55493867 @default.
• W4386009493 hasConcept C62231903 @default.
• W4386009493 hasConcept C71924100 @default.
• W4386009493 hasConcept C82714985 @default.
• W4386009493 hasConcept C85265743 @default.
• W4386009493 hasConceptScore W4386009493C104317684 @default.
• W4386009493 hasConceptScore W4386009493C111566952 @default.
• W4386009493 hasConceptScore W4386009493C123894998 @default.
• W4386009493 hasConceptScore W4386009493C126322002 @default.
• W4386009493 hasConceptScore W4386009493C127561419 @default.
• W4386009493 hasConceptScore W4386009493C134018914 @default.
• W4386009493 hasConceptScore W4386009493C163950672 @default.
• W4386009493 hasConceptScore W4386009493C170493617 @default.
• W4386009493 hasConceptScore W4386009493C185592680 @default.
• W4386009493 hasConceptScore W4386009493C24586158 @default.
• W4386009493 hasConceptScore W4386009493C2776415932 @default.
• W4386009493 hasConceptScore W4386009493C2776553924 @default.
• W4386009493 hasConceptScore W4386009493C2778198053 @default.
• W4386009493 hasConceptScore W4386009493C2778797674 @default.
• W4386009493 hasConceptScore W4386009493C40767141 @default.
• W4386009493 hasConceptScore W4386009493C55493867 @default.
• W4386009493 hasConceptScore W4386009493C62231903 @default.
• W4386009493 hasConceptScore W4386009493C71924100 @default.
• W4386009493 hasConceptScore W4386009493C82714985 @default.
• W4386009493 hasConceptScore W4386009493C85265743 @default.
• W4386009493 hasFunder F4320321001 @default.

• next