Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386009541> ?p ?o ?g. }
- W4386009541 endingPage "112965" @default.
- W4386009541 startingPage "112965" @default.
- W4386009541 abstract "Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy. Here, we develop the personalized genomics algorithm Hapster and accurately call somatic mutations within the MHC genes of 10,001 primary and 2,199 metastatic tumors, creating a catalog of 1,663 non-synonymous mutations that provide key insights into MHC mutagenesis. We find that MHC class I genes are among the most frequently mutated genes in both primary and metastatic tumors, while MHC class II mutations are more restricted. Recurrent deleterious mutations are found within haplotype- and cancer-type-specific hotspots associated with distinct mutational processes. Functional classification of MHC residues reveals significant positive selection for mutations disruptive to the B2M, peptide, and T cell binding interfaces, as well as to MHC chaperones." @default.
- W4386009541 created "2023-08-21" @default.
- W4386009541 creator A5003311852 @default.
- W4386009541 creator A5027414750 @default.
- W4386009541 creator A5044397683 @default.
- W4386009541 creator A5047599343 @default.
- W4386009541 creator A5051824786 @default.
- W4386009541 creator A5058907937 @default.
- W4386009541 creator A5070666882 @default.
- W4386009541 creator A5088147590 @default.
- W4386009541 date "2023-08-01" @default.
- W4386009541 modified "2023-09-26" @default.
- W4386009541 title "Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors" @default.
- W4386009541 cites W1107917109 @default.
- W4386009541 cites W1692743499 @default.
- W4386009541 cites W1759669640 @default.
- W4386009541 cites W1911343030 @default.
- W4386009541 cites W1956577542 @default.
- W4386009541 cites W1972999648 @default.
- W4386009541 cites W1982488143 @default.
- W4386009541 cites W1986937402 @default.
- W4386009541 cites W2003665515 @default.
- W4386009541 cites W2004177824 @default.
- W4386009541 cites W2016149207 @default.
- W4386009541 cites W2031102033 @default.
- W4386009541 cites W2054076276 @default.
- W4386009541 cites W2060320549 @default.
- W4386009541 cites W2085939929 @default.
- W4386009541 cites W2088891952 @default.
- W4386009541 cites W2089544326 @default.
- W4386009541 cites W2094334993 @default.
- W4386009541 cites W2097995306 @default.
- W4386009541 cites W2099570622 @default.
- W4386009541 cites W2107752337 @default.
- W4386009541 cites W2112752664 @default.
- W4386009541 cites W2123914905 @default.
- W4386009541 cites W2126547130 @default.
- W4386009541 cites W2130621814 @default.
- W4386009541 cites W2134232737 @default.
- W4386009541 cites W2139160625 @default.
- W4386009541 cites W2143163879 @default.
- W4386009541 cites W2144669901 @default.
- W4386009541 cites W2147210428 @default.
- W4386009541 cites W2150056019 @default.
- W4386009541 cites W2153932922 @default.
- W4386009541 cites W2162098634 @default.
- W4386009541 cites W2163544987 @default.
- W4386009541 cites W2175588024 @default.
- W4386009541 cites W2204392137 @default.
- W4386009541 cites W2214699570 @default.
- W4386009541 cites W2296828141 @default.
- W4386009541 cites W2301707196 @default.
- W4386009541 cites W2331480251 @default.
- W4386009541 cites W2543066836 @default.
- W4386009541 cites W2567564314 @default.
- W4386009541 cites W2605820408 @default.
- W4386009541 cites W2612936457 @default.
- W4386009541 cites W2728365508 @default.
- W4386009541 cites W2741363425 @default.
- W4386009541 cites W2741601602 @default.
- W4386009541 cites W2762980752 @default.
- W4386009541 cites W2766209631 @default.
- W4386009541 cites W2767399544 @default.
- W4386009541 cites W2784427696 @default.
- W4386009541 cites W2789843538 @default.
- W4386009541 cites W2790528406 @default.
- W4386009541 cites W2807045844 @default.
- W4386009541 cites W2890298773 @default.
- W4386009541 cites W2894573839 @default.
- W4386009541 cites W2943781197 @default.
- W4386009541 cites W2955719861 @default.
- W4386009541 cites W2959625518 @default.
- W4386009541 cites W2963603102 @default.
- W4386009541 cites W2965035617 @default.
- W4386009541 cites W2988620928 @default.
- W4386009541 cites W2990769829 @default.
- W4386009541 cites W2995387264 @default.
- W4386009541 cites W2995687998 @default.
- W4386009541 cites W3017379946 @default.
- W4386009541 cites W3021254998 @default.
- W4386009541 cites W3088419187 @default.
- W4386009541 cites W3119086885 @default.
- W4386009541 cites W3134746059 @default.
- W4386009541 doi "https://doi.org/10.1016/j.celrep.2023.112965" @default.
- W4386009541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597185" @default.
- W4386009541 hasPublicationYear "2023" @default.
- W4386009541 type Work @default.
- W4386009541 citedByCount "0" @default.
- W4386009541 crossrefType "journal-article" @default.
- W4386009541 hasAuthorship W4386009541A5003311852 @default.
- W4386009541 hasAuthorship W4386009541A5027414750 @default.
- W4386009541 hasAuthorship W4386009541A5044397683 @default.
- W4386009541 hasAuthorship W4386009541A5047599343 @default.
- W4386009541 hasAuthorship W4386009541A5051824786 @default.
- W4386009541 hasAuthorship W4386009541A5058907937 @default.
- W4386009541 hasAuthorship W4386009541A5070666882 @default.
- W4386009541 hasAuthorship W4386009541A5088147590 @default.
- W4386009541 hasBestOaLocation W43860095411 @default.