FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386009562> ?p ?o ?g. }

• W4386009562 abstract "G1P3/IFI6 is an interferon stimulated gene with antiapoptotic, prometastatic, and antiviral functions. Despite its pleiotropic functions, subcellular localization of G1P3 remains unclear. Using biochemical- and confocal microscopic approaches, this study identified the localization of G1P3 in organelles of the endomembrane system and in the mitochondria of breast cancer cells. In cell fractionation studies, both interferon-induced endogenous- and stably expressed G1P3 cofractionated with affinity-isolated mitochondria. Results of the protease protection assay have suggested that ~24% of mitochondrial G1P3 resides within the mitochondria. Conforming to this, confocal microscopy studies of cells stably expressing epitope-tagged G1P3 (MCF-7/G1P3-FLAG), identified its localization in mitochondria (~38%) as well as in ER, trans-Golgi network (TGN), lysosomes, and in RAB5 positive (RAB5+ ) endosomes. These results suggested the trafficking of G1P3 from TGN into endolysosomes. Both G1P3 and RAB5 were known to confer apoptosis resistance through mitochondrial stabilization. Therefore, the effects of G1P3 on the localization of RAB5 in mitochondria were tested. Compared to vector control, the co-occurrence of RAB5 with the mitochondria was increased by 1.5-fold in MCF-7/G1P3-FLAG expressing cells (p ≤ .005). Taken together, our results demonstrate a role for G1P3 to promote the association of RAB5+ endosomes with mitochondria and provide insight into yet another mechanism of G1P3-induced cancer cell survival." @default.
• W4386009562 created "2023-08-21" @default.
• W4386009562 creator A5035846094 @default.
• W4386009562 creator A5059760764 @default.
• W4386009562 creator A5078285224 @default.
• W4386009562 creator A5086469451 @default.
• W4386009562 creator A5092667067 @default.
• W4386009562 creator A5092667068 @default.
• W4386009562 creator A5092667069 @default.
• W4386009562 date "2023-08-20" @default.
• W4386009562 modified "2023-10-13" @default.
• W4386009562 title "G1P3/IFI6, an interferon stimulated protein, promotes the association of RAB5⁺ endosomes with mitochondria in breast cancer cells" @default.
• W4386009562 cites W1584086642 @default.
• W4386009562 cites W1622488271 @default.
• W4386009562 cites W1846605417 @default.
• W4386009562 cites W1883864413 @default.
• W4386009562 cites W1970105862 @default.
• W4386009562 cites W1982705188 @default.
• W4386009562 cites W1988194926 @default.
• W4386009562 cites W2000282041 @default.
• W4386009562 cites W2020183718 @default.
• W4386009562 cites W2022050193 @default.
• W4386009562 cites W2041758725 @default.
• W4386009562 cites W2046133662 @default.
• W4386009562 cites W2046282425 @default.
• W4386009562 cites W2051956247 @default.
• W4386009562 cites W2061154433 @default.
• W4386009562 cites W2066845132 @default.
• W4386009562 cites W2085971109 @default.
• W4386009562 cites W2094694100 @default.
• W4386009562 cites W2098329073 @default.
• W4386009562 cites W2104049989 @default.
• W4386009562 cites W2110054105 @default.
• W4386009562 cites W2124417027 @default.
• W4386009562 cites W2131242974 @default.
• W4386009562 cites W2134091914 @default.
• W4386009562 cites W2146926129 @default.
• W4386009562 cites W2289876562 @default.
• W4386009562 cites W2517031580 @default.
• W4386009562 cites W2581301471 @default.
• W4386009562 cites W2762910600 @default.
• W4386009562 cites W2785967221 @default.
• W4386009562 cites W2790553047 @default.
• W4386009562 cites W2792021782 @default.
• W4386009562 cites W2804880951 @default.
• W4386009562 cites W2808557125 @default.
• W4386009562 cites W2890461213 @default.
• W4386009562 cites W2947754531 @default.
• W4386009562 cites W2984396125 @default.
• W4386009562 cites W3011930227 @default.
• W4386009562 cites W3045860853 @default.
• W4386009562 cites W3088656247 @default.
• W4386009562 cites W3112314595 @default.
• W4386009562 cites W3146395015 @default.
• W4386009562 cites W3152595693 @default.
• W4386009562 cites W3194937926 @default.
• W4386009562 cites W3196152335 @default.
• W4386009562 cites W3216503740 @default.
• W4386009562 cites W4200565862 @default.
• W4386009562 cites W4306175472 @default.
• W4386009562 cites W4308144737 @default.
• W4386009562 doi "https://doi.org/10.1002/cbin.12079" @default.
• W4386009562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37598317" @default.
• W4386009562 hasPublicationYear "2023" @default.
• W4386009562 type Work @default.
• W4386009562 citedByCount "0" @default.
• W4386009562 crossrefType "journal-article" @default.
• W4386009562 hasAuthorship W4386009562A5035846094 @default.
• W4386009562 hasAuthorship W4386009562A5059760764 @default.
• W4386009562 hasAuthorship W4386009562A5078285224 @default.
• W4386009562 hasAuthorship W4386009562A5086469451 @default.
• W4386009562 hasAuthorship W4386009562A5092667067 @default.
• W4386009562 hasAuthorship W4386009562A5092667068 @default.
• W4386009562 hasAuthorship W4386009562A5092667069 @default.
• W4386009562 hasConcept C102747710 @default.
• W4386009562 hasConcept C119062480 @default.
• W4386009562 hasConcept C121608353 @default.
• W4386009562 hasConcept C158617107 @default.
• W4386009562 hasConcept C168240541 @default.
• W4386009562 hasConcept C190062978 @default.
• W4386009562 hasConcept C27239569 @default.
• W4386009562 hasConcept C2776879804 @default.
• W4386009562 hasConcept C28859421 @default.
• W4386009562 hasConcept C41625074 @default.
• W4386009562 hasConcept C54355233 @default.
• W4386009562 hasConcept C55493867 @default.
• W4386009562 hasConcept C79879829 @default.
• W4386009562 hasConcept C86803240 @default.
• W4386009562 hasConcept C95444343 @default.
• W4386009562 hasConcept C96232424 @default.
• W4386009562 hasConceptScore W4386009562C102747710 @default.
• W4386009562 hasConceptScore W4386009562C119062480 @default.
• W4386009562 hasConceptScore W4386009562C121608353 @default.
• W4386009562 hasConceptScore W4386009562C158617107 @default.
• W4386009562 hasConceptScore W4386009562C168240541 @default.
• W4386009562 hasConceptScore W4386009562C190062978 @default.
• W4386009562 hasConceptScore W4386009562C27239569 @default.
• W4386009562 hasConceptScore W4386009562C2776879804 @default.
• W4386009562 hasConceptScore W4386009562C28859421 @default.
• W4386009562 hasConceptScore W4386009562C41625074 @default.

• next