FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386009571> ?p ?o ?g. }

• W4386009571 endingPage "100926" @default.
• W4386009571 startingPage "100926" @default.
• W4386009571 abstract "The Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregulated, may contribute to several cancers, including basal cell carcinoma, medulloblastoma, colorectal, prostate, and pancreatic cancer. In recent years, several Hh inhibitors have been developed, mainly acting on the Smo receptor. However, drug resistance due to Smo mutations or non-canonical Hh pathway activation highlights the need to identify further mechanisms of Hh pathway modulation. Among these, deacetylation of the Hh transcription factor Gli1 by the histone deacetylase HDAC1 increases Hh activity. On the other end, the KCASH family of oncosuppressors binds HDAC1, leading to its ubiquitination and subsequent proteasomal degradation, leaving Gli1 acetylated and not active. It was recently demonstrated that the potassium channel containing protein KCTD15 is able to interact with KCASH2 protein and stabilize it, enhancing its effect on HDAC1 and Hh pathway. KCTD15 and KCTD1 proteins share a high homology and are clustered in a specific KCTD subfamily. We characterize here KCTD1 role on the Hh pathway. Therefore, we demonstrated KCTD1 interaction with KCASH1 and KCASH2 proteins, and its role in their stabilization by reducing their ubiquitination and proteasome-mediated degradation. Consequently, KCTD1 expression reduces HDAC1 protein levels and Hh/Gli1 activity, inhibiting Hh dependent cell proliferation in Hh tumour cells. Furthermore, analysis of expression data on publicly available databases indicates that KCTD1 expression is reduced in Hh dependent MB samples, compared to normal cerebella, suggesting that KCTD1 may represent a new putative target for therapeutic approaches against Hh-dependent tumour." @default.
• W4386009571 created "2023-08-21" @default.
• W4386009571 creator A5005623826 @default.
• W4386009571 creator A5025181549 @default.
• W4386009571 creator A5028007630 @default.
• W4386009571 creator A5040021957 @default.
• W4386009571 creator A5040712171 @default.
• W4386009571 creator A5044015765 @default.
• W4386009571 creator A5044346256 @default.
• W4386009571 creator A5052670103 @default.
• W4386009571 creator A5077798210 @default.
• W4386009571 creator A5078870848 @default.
• W4386009571 creator A5079548793 @default.
• W4386009571 creator A5083283790 @default.
• W4386009571 creator A5089989090 @default.
• W4386009571 creator A5090879878 @default.
• W4386009571 creator A5092667073 @default.
• W4386009571 creator A5092667074 @default.
• W4386009571 date "2023-09-01" @default.
• W4386009571 modified "2023-09-25" @default.
• W4386009571 title "KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors" @default.
• W4386009571 cites W1566344473 @default.
• W4386009571 cites W2012112208 @default.
• W4386009571 cites W2016280793 @default.
• W4386009571 cites W2016930511 @default.
• W4386009571 cites W2036423771 @default.
• W4386009571 cites W2048368626 @default.
• W4386009571 cites W2051972832 @default.
• W4386009571 cites W2067131186 @default.
• W4386009571 cites W2078406365 @default.
• W4386009571 cites W2083920998 @default.
• W4386009571 cites W2084667421 @default.
• W4386009571 cites W2107031745 @default.
• W4386009571 cites W2111197864 @default.
• W4386009571 cites W2127330552 @default.
• W4386009571 cites W2131838602 @default.
• W4386009571 cites W2164786397 @default.
• W4386009571 cites W2165908624 @default.
• W4386009571 cites W2180087861 @default.
• W4386009571 cites W2399137066 @default.
• W4386009571 cites W2424638636 @default.
• W4386009571 cites W2737542366 @default.
• W4386009571 cites W2757120118 @default.
• W4386009571 cites W2798230186 @default.
• W4386009571 cites W282155303 @default.
• W4386009571 cites W2885434620 @default.
• W4386009571 cites W2885938058 @default.
• W4386009571 cites W2899003723 @default.
• W4386009571 cites W2900187612 @default.
• W4386009571 cites W2911539447 @default.
• W4386009571 cites W2950644483 @default.
• W4386009571 cites W2950970502 @default.
• W4386009571 cites W2963390573 @default.
• W4386009571 cites W2971116945 @default.
• W4386009571 cites W2983366905 @default.
• W4386009571 cites W2998415228 @default.
• W4386009571 cites W3045514492 @default.
• W4386009571 cites W3153812749 @default.
• W4386009571 cites W3159690225 @default.
• W4386009571 cites W3162246480 @default.
• W4386009571 cites W3179452994 @default.
• W4386009571 cites W3197537712 @default.
• W4386009571 cites W3198108359 @default.
• W4386009571 cites W4308119366 @default.
• W4386009571 cites W4327811873 @default.
• W4386009571 cites W4328097133 @default.
• W4386009571 cites W4381930220 @default.
• W4386009571 doi "https://doi.org/10.1016/j.neo.2023.100926" @default.
• W4386009571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597490" @default.
• W4386009571 hasPublicationYear "2023" @default.
• W4386009571 type Work @default.
• W4386009571 citedByCount "0" @default.
• W4386009571 crossrefType "journal-article" @default.
• W4386009571 hasAuthorship W4386009571A5005623826 @default.
• W4386009571 hasAuthorship W4386009571A5025181549 @default.
• W4386009571 hasAuthorship W4386009571A5028007630 @default.
• W4386009571 hasAuthorship W4386009571A5040021957 @default.
• W4386009571 hasAuthorship W4386009571A5040712171 @default.
• W4386009571 hasAuthorship W4386009571A5044015765 @default.
• W4386009571 hasAuthorship W4386009571A5044346256 @default.
• W4386009571 hasAuthorship W4386009571A5052670103 @default.
• W4386009571 hasAuthorship W4386009571A5077798210 @default.
• W4386009571 hasAuthorship W4386009571A5078870848 @default.
• W4386009571 hasAuthorship W4386009571A5079548793 @default.
• W4386009571 hasAuthorship W4386009571A5083283790 @default.
• W4386009571 hasAuthorship W4386009571A5089989090 @default.
• W4386009571 hasAuthorship W4386009571A5090879878 @default.
• W4386009571 hasAuthorship W4386009571A5092667073 @default.
• W4386009571 hasAuthorship W4386009571A5092667074 @default.
• W4386009571 hasBestOaLocation W43860095711 @default.
• W4386009571 hasConcept C104317684 @default.
• W4386009571 hasConcept C145837895 @default.
• W4386009571 hasConcept C2778305200 @default.
• W4386009571 hasConcept C2778539099 @default.
• W4386009571 hasConcept C2779933373 @default.
• W4386009571 hasConcept C502942594 @default.
• W4386009571 hasConcept C55493867 @default.
• W4386009571 hasConcept C62478195 @default.

• next