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- W4386010945 abstract "ABSTRACTThe effects of ethanolic leaf extract of Tinospora cordifolia (ELETC) and its loaded phytoniosomes (nELETC) on altered hormonal levels in female polycystic ovarian syndrome (PCOS) rats induced by mifepristone were investigated. Mifepristone (4 mg kg−1 b.w.) was given daily to female rats for 8 days to develop PCOS, which was then detected by a protracted estrous cycle. The treatment regimen for the rats with PCOS consisted of 200 mg kg−1 b.w. of ELETC and nELETC administered orally every day for 28 days. Hormone tests showed that metformin acted as a favorable control. Results demonstrated that ELETC and nELETC may be used as therapeutic alternatives for treating PCOS to decrease complications of hyperinsulinemia, insulin resistance, and hyperandrogenism.KEYWORDS: PhytoniosomeshormonesPCOS AcknowledgmentsWe gratefully acknowledge Er. A.C.S. Arun Kumar, President, Dr. M.G.R Educational and Research Institute University for providing the necessary facilities.Disclosure statementNo potential conflict of interest was reported by the author(s)." @default.
- W4386010945 created "2023-08-21" @default.
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- W4386010945 date "2023-08-20" @default.
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- W4386010945 title "Hormonal Regulatory Impacts of <i>Tinospora cordifolia</i> Leaf Extract and Its Loaded Phytoniosome on Mifepristone-Induced Polycystic Ovarian Syndrome (PCOS) Rats – <i>In Vivo</i> Studies" @default.
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- W4386010945 doi "https://doi.org/10.1080/10496475.2023.2248050" @default.
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