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- W4386011253 abstract ": Insulin-loaded Trimethyl Chitosan (TMC)/tragacanth microspheres were prepared by microemulsion dispersion and triggered in situ gelation. Microspheres were characterized by their mean size and distribution by laser diffraction spectroscopy and Brunauer-Emmet-Teller theory. Insulin encapsulation efficiency and in vitro release were determined by Bradford protein assay, and bioactivity was assessed in vitro using an enzyme-linked immunoassay diagnostic kit and in vivo using Wistar diabetic rats. TMC/tragacanth particles suppressed insulin release in acidic media and promoted a sustained release at near-neutral conditions. Micro-capsulated insulin was bioactive, demonstrated by both in vivo and in vitro bioassays." @default.
- W4386011253 created "2023-08-21" @default.
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- W4386011253 date "2023-08-20" @default.
- W4386011253 modified "2023-10-02" @default.
- W4386011253 title "Oral Delivery of Insulin from Trimethyl Chitosan/Tragacanth: In vitro, MTT, and In vivo Bioactivity Tests" @default.
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- W4386011253 doi "https://doi.org/10.5812/amh-137796" @default.
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