Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386012893> ?p ?o ?g. }
- W4386012893 endingPage "100287" @default.
- W4386012893 startingPage "100287" @default.
- W4386012893 abstract "An essential step in the entrance of enveloped viruses such as coronaviruses, the human immunodeficiency virus, and influenza is membrane fusion. A unique class of glycoprotein found on the viral envelope, known as a fusion protein, is responsible for catalyzing the fusion between the viral envelope and the host cell. Efforts have been made to block the fusion vis-à-vis the entry process by inactivating the fusion protein utilizing peptides and small molecules. Interestingly, the fusion proteins do not have any structural and sequence homology across viruses, and this limited the use of inhibitory peptides against a specific virus causing a paucity of immediate solutions against emerging and re-emerging viral diseases. Therefore, research has been initiated to develop broad-spectrum fusion inhibitors that can be effective to inhibit the entry of many viruses. In this review, we have examined the mechanistic details of membrane fusion and the potential significance of lipid composition. Moreover, we discussed the rationale for developing peptide-based, broad-spectrum fusion inhibitors that target membrane physical characteristics instead of fusion protein inactivation." @default.
- W4386012893 created "2023-08-21" @default.
- W4386012893 creator A5019339613 @default.
- W4386012893 creator A5045162011 @default.
- W4386012893 creator A5091364871 @default.
- W4386012893 date "2023-12-01" @default.
- W4386012893 modified "2023-10-02" @default.
- W4386012893 title "Fusion peptide induced modification of membrane organization and dynamics: Implications in developing fusion inhibitors" @default.
- W4386012893 cites W115975460 @default.
- W4386012893 cites W1535018103 @default.
- W4386012893 cites W1541232 @default.
- W4386012893 cites W1588803833 @default.
- W4386012893 cites W1905114611 @default.
- W4386012893 cites W1964881184 @default.
- W4386012893 cites W1965359726 @default.
- W4386012893 cites W1966105418 @default.
- W4386012893 cites W1966868696 @default.
- W4386012893 cites W1969337788 @default.
- W4386012893 cites W1971099435 @default.
- W4386012893 cites W1971976535 @default.
- W4386012893 cites W1976400886 @default.
- W4386012893 cites W1985660854 @default.
- W4386012893 cites W1986611140 @default.
- W4386012893 cites W1987314655 @default.
- W4386012893 cites W1988398351 @default.
- W4386012893 cites W1989144616 @default.
- W4386012893 cites W1990814910 @default.
- W4386012893 cites W1992683016 @default.
- W4386012893 cites W1993374993 @default.
- W4386012893 cites W1993875393 @default.
- W4386012893 cites W2000872543 @default.
- W4386012893 cites W2001559319 @default.
- W4386012893 cites W2003792573 @default.
- W4386012893 cites W2004313693 @default.
- W4386012893 cites W2005152944 @default.
- W4386012893 cites W2005241727 @default.
- W4386012893 cites W2005780220 @default.
- W4386012893 cites W2006288553 @default.
- W4386012893 cites W2007865458 @default.
- W4386012893 cites W2013436408 @default.
- W4386012893 cites W2013714141 @default.
- W4386012893 cites W2016487394 @default.
- W4386012893 cites W2019145560 @default.
- W4386012893 cites W2019251493 @default.
- W4386012893 cites W2021635942 @default.
- W4386012893 cites W2027744693 @default.
- W4386012893 cites W2029513462 @default.
- W4386012893 cites W2033069947 @default.
- W4386012893 cites W2033757712 @default.
- W4386012893 cites W2034582764 @default.
- W4386012893 cites W2036656105 @default.
- W4386012893 cites W2038543621 @default.
- W4386012893 cites W2038769526 @default.
- W4386012893 cites W2040106762 @default.
- W4386012893 cites W2041270739 @default.
- W4386012893 cites W2044318948 @default.
- W4386012893 cites W2044406786 @default.
- W4386012893 cites W2045032922 @default.
- W4386012893 cites W2048172399 @default.
- W4386012893 cites W2048492877 @default.
- W4386012893 cites W2050043453 @default.
- W4386012893 cites W2051785641 @default.
- W4386012893 cites W2053137976 @default.
- W4386012893 cites W2054826352 @default.
- W4386012893 cites W2054907422 @default.
- W4386012893 cites W2058834304 @default.
- W4386012893 cites W2059370862 @default.
- W4386012893 cites W2061417691 @default.
- W4386012893 cites W2063412344 @default.
- W4386012893 cites W2067552300 @default.
- W4386012893 cites W2067693929 @default.
- W4386012893 cites W2068971025 @default.
- W4386012893 cites W2069856609 @default.
- W4386012893 cites W2072167784 @default.
- W4386012893 cites W2076016977 @default.
- W4386012893 cites W2076591390 @default.
- W4386012893 cites W2077963467 @default.
- W4386012893 cites W2078019232 @default.
- W4386012893 cites W2083530644 @default.
- W4386012893 cites W2086493164 @default.
- W4386012893 cites W2087870820 @default.
- W4386012893 cites W2088536371 @default.
- W4386012893 cites W2091847883 @default.
- W4386012893 cites W2092568903 @default.
- W4386012893 cites W2096025413 @default.
- W4386012893 cites W2096950500 @default.
- W4386012893 cites W2097305591 @default.
- W4386012893 cites W2097694462 @default.
- W4386012893 cites W2101762911 @default.
- W4386012893 cites W2103684614 @default.
- W4386012893 cites W2106967530 @default.
- W4386012893 cites W2107756045 @default.
- W4386012893 cites W2107860569 @default.
- W4386012893 cites W2107920732 @default.
- W4386012893 cites W2111491631 @default.
- W4386012893 cites W2111620983 @default.
- W4386012893 cites W2112941072 @default.
- W4386012893 cites W2118978641 @default.