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• W4386019093 abstract "Niemann-Pick C (NPC) disease is a neurodegenerative disorder related to cellular sterol trafficking and mutation of NPC1 gene is the main cause for this disease. The function of NPC1 have been reported in a few insects but rarely studied in hemipterans. In the present study, we investigate the function of NPC1 in a hemipteran pest, the whitefly Bemisia tabaci. It was found that B. tabaci had only one NPC1 homolog (BtNPC1), in contrast to two homologs in many other insects. BtNPC1 was ubiquitously expressed at all developmental stages and body parts of whiteflies, with the highest level in adult abdomen, and the expression of BtNPC1 was induced by cholesterol feeding. To further investigate the function of BtNPC1, leaf-mediated RNA interference experiments were carried out. Results showed that knockdown of BtNPC1 led to reduced survival of whiteflies, as well as reduced fecundity. Moreover, knockdown of BtNPC1 affected the development and metamorphosis of whitefly nymphs. Taken these together, we conclude that BtNPC1 played a crucial role in sterol-related biological processes of B. tabaci and might be used as an insecticide target for development of novel pest management approaches." @default.
• W4386019093 created "2023-08-22" @default.
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• W4386019093 date "2023-08-21" @default.
• W4386019093 modified "2023-10-18" @default.
• W4386019093 title "Functional analysis of a NPC1 gene from the whitefly, <i>Bemisia tabaci</i> (Hemiptera: Aleyrodidae)" @default.
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• W4386019093 doi "https://doi.org/10.1002/arch.22048" @default.
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