FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386019448> ?p ?o ?g. }

• W4386019448 abstract "NDUFA4 is a component of respiratory chain–oxidative phosphorylation pathway. NDUFA4 is highly expressed in tumor tissues, but little is known about the function of NDUFA4 in head and neck paraganglioma (HNPGL). We examined NDUFA4 expression in tissues from 10 HNPGL patients and 6 controls using qRT-PCR and Western blotting. NDUFA4 knockdown PGL-626 cells were established by using lentivirus infection and puromycin screening. Cell viability, ATP production, lipid reactive oxygen species, and mitochondrial membrane potential assays were performed to investigate the ferroptotic effects in NDUFA4 deficiency HNPGL cancer cells. Xenograft mouse model was created to detect the synergetic antitumor action between NDUFA4 deficiency and Metformin. NDUFA4 was upregulated in tumor tissues of HNPGL patients. NDUFA4 knockdown impaired the assembly of mitochondrial respiratory chain complexes and decreased the production of ATP and reduced cancer cell viability. Mechanistically, NDUFA4 knockdown increased cell ferroptosis, which further promoted Metformin-induced ferroptosis in PGL-626 cells. Therefore, NDUFA4 deficiency enhanced Metformin-mediated inhibition of the HNPGL progression in mice. In conclusion, NDUFA4 promotes the progression of HNPGL, and NDUFA4 knockdown enhances Metformin-mediated inhibition of the HNPGL progression in a mouse model." @default.
• W4386019448 created "2023-08-22" @default.
• W4386019448 creator A5010705747 @default.
• W4386019448 creator A5012595846 @default.
• W4386019448 creator A5015195367 @default.
• W4386019448 creator A5017353282 @default.
• W4386019448 creator A5023086562 @default.
• W4386019448 creator A5030530558 @default.
• W4386019448 creator A5050053836 @default.
• W4386019448 creator A5056541697 @default.
• W4386019448 creator A5060589461 @default.
• W4386019448 date "2023-08-21" @default.
• W4386019448 modified "2023-09-27" @default.
• W4386019448 title "NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis" @default.
• W4386019448 cites W1975617209 @default.
• W4386019448 cites W1982777876 @default.
• W4386019448 cites W1997183854 @default.
• W4386019448 cites W2060271974 @default.
• W4386019448 cites W2061662711 @default.
• W4386019448 cites W2088339105 @default.
• W4386019448 cites W2093711185 @default.
• W4386019448 cites W2093977679 @default.
• W4386019448 cites W2114138419 @default.
• W4386019448 cites W2120501725 @default.
• W4386019448 cites W2135601427 @default.
• W4386019448 cites W2265062179 @default.
• W4386019448 cites W2514722514 @default.
• W4386019448 cites W2561449450 @default.
• W4386019448 cites W2585589460 @default.
• W4386019448 cites W2767687555 @default.
• W4386019448 cites W2773927148 @default.
• W4386019448 cites W2795823856 @default.
• W4386019448 cites W2808878881 @default.
• W4386019448 cites W2891375731 @default.
• W4386019448 cites W2896442590 @default.
• W4386019448 cites W2904715359 @default.
• W4386019448 cites W2906319220 @default.
• W4386019448 cites W2953831294 @default.
• W4386019448 cites W2969928163 @default.
• W4386019448 cites W2985065511 @default.
• W4386019448 cites W3003960907 @default.
• W4386019448 cites W3016404848 @default.
• W4386019448 cites W3093411526 @default.
• W4386019448 cites W3135701827 @default.
• W4386019448 cites W3163145088 @default.
• W4386019448 cites W3167811573 @default.
• W4386019448 cites W4295222520 @default.
• W4386019448 cites W4307584564 @default.
• W4386019448 cites W81784605 @default.
• W4386019448 doi "https://doi.org/10.1139/bcb-2023-0018" @default.
• W4386019448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37602474" @default.
• W4386019448 hasPublicationYear "2023" @default.
• W4386019448 type Work @default.
• W4386019448 citedByCount "0" @default.
• W4386019448 crossrefType "journal-article" @default.
• W4386019448 hasAuthorship W4386019448A5010705747 @default.
• W4386019448 hasAuthorship W4386019448A5012595846 @default.
• W4386019448 hasAuthorship W4386019448A5015195367 @default.
• W4386019448 hasAuthorship W4386019448A5017353282 @default.
• W4386019448 hasAuthorship W4386019448A5023086562 @default.
• W4386019448 hasAuthorship W4386019448A5030530558 @default.
• W4386019448 hasAuthorship W4386019448A5050053836 @default.
• W4386019448 hasAuthorship W4386019448A5056541697 @default.
• W4386019448 hasAuthorship W4386019448A5060589461 @default.
• W4386019448 hasConcept C104317684 @default.
• W4386019448 hasConcept C127561419 @default.
• W4386019448 hasConcept C134018914 @default.
• W4386019448 hasConcept C1491633281 @default.
• W4386019448 hasConcept C153911025 @default.
• W4386019448 hasConcept C173396325 @default.
• W4386019448 hasConcept C185592680 @default.
• W4386019448 hasConcept C190283241 @default.
• W4386019448 hasConcept C2780323712 @default.
• W4386019448 hasConcept C28859421 @default.
• W4386019448 hasConcept C48349386 @default.
• W4386019448 hasConcept C502942594 @default.
• W4386019448 hasConcept C53227056 @default.
• W4386019448 hasConcept C55493867 @default.
• W4386019448 hasConcept C555293320 @default.
• W4386019448 hasConcept C86803240 @default.
• W4386019448 hasConcept C95444343 @default.
• W4386019448 hasConceptScore W4386019448C104317684 @default.
• W4386019448 hasConceptScore W4386019448C127561419 @default.
• W4386019448 hasConceptScore W4386019448C134018914 @default.
• W4386019448 hasConceptScore W4386019448C1491633281 @default.
• W4386019448 hasConceptScore W4386019448C153911025 @default.
• W4386019448 hasConceptScore W4386019448C173396325 @default.
• W4386019448 hasConceptScore W4386019448C185592680 @default.
• W4386019448 hasConceptScore W4386019448C190283241 @default.
• W4386019448 hasConceptScore W4386019448C2780323712 @default.
• W4386019448 hasConceptScore W4386019448C28859421 @default.
• W4386019448 hasConceptScore W4386019448C48349386 @default.
• W4386019448 hasConceptScore W4386019448C502942594 @default.
• W4386019448 hasConceptScore W4386019448C53227056 @default.
• W4386019448 hasConceptScore W4386019448C55493867 @default.
• W4386019448 hasConceptScore W4386019448C555293320 @default.
• W4386019448 hasConceptScore W4386019448C86803240 @default.
• W4386019448 hasConceptScore W4386019448C95444343 @default.
• W4386019448 hasLocation W43860194481 @default.
• W4386019448 hasLocation W43860194482 @default.

• next