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- W4386019611 abstract "Abstract The Flaviviridae family comprises positive‐sense single‐strand RNA viruses mainly transmitted by arthropods. Many of these pathogens are especially deleterious to the nervous system, and a myriad of neurological symptoms have been associated with infections by Zika virus (ZIKV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) in humans. Studies suggest that viral replication in neural cells and the massive release of pro‐inflammatory mediators lead to morphological alterations of synaptic spine structure and changes in the balance of excitatory/inhibitory neurotransmitters and receptors. Glutamate is the predominant excitatory neurotransmitter in the brain, and studies propose that either enhanced release or impaired uptake of this amino acid contribute s to brain damage in several conditions. Here, we review existing evidence suggesting that glutamatergic dysfunction ‐ induced by flaviviruses is a central mechanism for neurological damage and clinical outcomes of infection. We also discuss current data suggesting that pharmacological approaches that counteract glutamatergic dysfunction show benefits in animal models of such viral diseases. image" @default.
- W4386019611 created "2023-08-22" @default.
- W4386019611 creator A5002641462 @default.
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- W4386019611 creator A5051529026 @default.
- W4386019611 creator A5065016535 @default.
- W4386019611 creator A5092668062 @default.
- W4386019611 date "2023-08-21" @default.
- W4386019611 modified "2023-10-17" @default.
- W4386019611 title "Fundamental neurochemistry review: Glutamatergic dysfunction as a central mechanism underlying flavivirus‐induced neurological damage" @default.
- W4386019611 cites W14748109 @default.
- W4386019611 cites W1519351707 @default.
- W4386019611 cites W1686065874 @default.
- W4386019611 cites W1968298120 @default.
- W4386019611 cites W1973409765 @default.
- W4386019611 cites W1973764097 @default.
- W4386019611 cites W1977472501 @default.
- W4386019611 cites W1991538811 @default.
- W4386019611 cites W1992521533 @default.
- W4386019611 cites W1996565222 @default.
- W4386019611 cites W2007895191 @default.
- W4386019611 cites W2011912865 @default.
- W4386019611 cites W2012297153 @default.
- W4386019611 cites W2013852605 @default.
- W4386019611 cites W2015237292 @default.
- W4386019611 cites W2036587958 @default.
- W4386019611 cites W2037257064 @default.
- W4386019611 cites W2037852973 @default.
- W4386019611 cites W2038220721 @default.
- W4386019611 cites W2050861170 @default.
- W4386019611 cites W2057838669 @default.
- W4386019611 cites W2072465507 @default.
- W4386019611 cites W2074147499 @default.
- W4386019611 cites W2082696829 @default.
- W4386019611 cites W2082879602 @default.
- W4386019611 cites W2103964958 @default.
- W4386019611 cites W2104404284 @default.
- W4386019611 cites W2114022608 @default.
- W4386019611 cites W2128970995 @default.
- W4386019611 cites W2144641296 @default.
- W4386019611 cites W2146740641 @default.
- W4386019611 cites W2147654688 @default.
- W4386019611 cites W2162637899 @default.
- W4386019611 cites W2166070786 @default.
- W4386019611 cites W2166305421 @default.
- W4386019611 cites W2166479596 @default.
- W4386019611 cites W2186283978 @default.
- W4386019611 cites W2190725993 @default.
- W4386019611 cites W2288868071 @default.
- W4386019611 cites W2312562146 @default.
- W4386019611 cites W2329413583 @default.
- W4386019611 cites W2469040304 @default.
- W4386019611 cites W2515305272 @default.
- W4386019611 cites W2528833623 @default.
- W4386019611 cites W2546889486 @default.
- W4386019611 cites W2557039335 @default.
- W4386019611 cites W2576689026 @default.
- W4386019611 cites W2596232252 @default.
- W4386019611 cites W2600108236 @default.
- W4386019611 cites W2609182408 @default.
- W4386019611 cites W2745620327 @default.
- W4386019611 cites W2747026281 @default.
- W4386019611 cites W2754665021 @default.
- W4386019611 cites W2770222691 @default.
- W4386019611 cites W2780265949 @default.
- W4386019611 cites W2792953149 @default.
- W4386019611 cites W2796008698 @default.
- W4386019611 cites W2802259113 @default.
- W4386019611 cites W2804929963 @default.
- W4386019611 cites W2805786155 @default.
- W4386019611 cites W2806242691 @default.
- W4386019611 cites W2888272437 @default.
- W4386019611 cites W2889182141 @default.
- W4386019611 cites W2909455163 @default.
- W4386019611 cites W2912089311 @default.
- W4386019611 cites W2932660702 @default.
- W4386019611 cites W2954018295 @default.
- W4386019611 cites W2968484106 @default.
- W4386019611 cites W2991307128 @default.
- W4386019611 cites W2995845322 @default.
- W4386019611 cites W2997806547 @default.
- W4386019611 cites W3002961887 @default.
- W4386019611 cites W3011730446 @default.
- W4386019611 cites W3017538594 @default.
- W4386019611 cites W3023251337 @default.
- W4386019611 cites W3035718841 @default.
- W4386019611 cites W3042278150 @default.
- W4386019611 cites W3042539412 @default.
- W4386019611 cites W3111015537 @default.
- W4386019611 cites W3113792226 @default.
- W4386019611 cites W3132440570 @default.
- W4386019611 cites W3148203401 @default.
- W4386019611 cites W3183416417 @default.
- W4386019611 cites W3189715865 @default.
- W4386019611 cites W3204854304 @default.
- W4386019611 cites W4210929878 @default.
- W4386019611 cites W4213195620 @default.
- W4386019611 cites W4229366171 @default.