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• W4386019747 abstract "The peripheral and central auditory subsystems together form a complex sensory network that allows an organism to hear. The genetic programs of the two subsystems must therefore be tightly coordinated during development. Yet, their interactions and common expression pathways have never been systematically explored. MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and are essential for normal development of the auditory system. We performed mRNA and small-RNA sequencing of organs from both auditory subsystems at three critical developmental timepoints (E16, P0, P16) to obtain a comprehensive and unbiased insight of their expression profiles. Our analysis reveals common and organ-specific expression patterns for differentially regulated mRNAs and miRNAs, which could be clustered with a particular selection of functions such as inner ear development, Wnt signalling, K+ transport, and axon guidance, based on gene ontology. Bioinformatics detected enrichment of predicted targets of specific miRNAs in the clusters and predicted regulatory interactions by monitoring opposite trends of expression of miRNAs and their targets. This approach identified six miRNAs as strong regulatory candidates for both subsystems. Among them was miR-96, an established critical factor for proper development in both subsystems, demonstrating the strength of our approach. We suggest that other miRNAs identified by this analysis are also common effectors of proper hearing acquirement. This first combined comprehensive analysis of the developmental program of the peripheral and central auditory systems provides important data and bioinformatics insights into the shared genetic program of the two sensory subsystems and their regulation by miRNAs." @default.
• W4386019747 created "2023-08-22" @default.
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• W4386019747 date "2023-08-21" @default.
• W4386019747 modified "2023-09-23" @default.
• W4386019747 title "Shared and organ-specific gene-expression programs during the development of the cochlea and the superior olivary complex" @default.
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• W4386019747 doi "https://doi.org/10.1080/15476286.2023.2247628" @default.
• W4386019747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37602850" @default.
• W4386019747 hasPublicationYear "2023" @default.
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