FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386020036> ?p ?o ?g. }

• W4386020036 abstract "Calcium channel blocker (CCB) is known to possess antibacterial effects. We aimed to apply network pharmacology (docking and protein-protein interaction [PPI] analyses) to predict the potential targets and mechanisms of CCB against Pseudomonas aeruginosa (PA) as well as to verify the effect of these drugs. The chemical structures of three CCBs were obtained through the Drug Bank platform. The potential channel proteins, efflux pump proteins and ion channel proteins of CCB against bacteria were derived from the literature. These proteins were collected through the PDB and Uniprot platform. The binding mode of the docking complexes was simulated by the CB-Dock platform and Discovery Studio 2019 Client software. The PPI network was constructed by the String platform and Cytoscape 3.8.2 platform. GO was explained by the PANTHER platform. The pathway diagram was drawn with the Pathway Builder Tool 2.0 software. The inhibitory effect of CCB on PA was verified through antibacterial experiments. Finally, 76 proteins were obtained: the iron channel protein of PA demonstrated a good docking relationship with all three CCBs, and the optimum binding energy was approximately -9.0 kcal/mol. GO analysis (biological process [BP], cellular component [CC], and molecular function [MF]) of protein genes showed a good docking relationship (optimum binding energy <-8.0 kcal/mol). The MF annotation results indicated that the target of CCB may be present on the PA membrane protein. The ion channel protein PPI enrichment p-value was 6.65e-08, and PfeA showed the strongest correlation. The experimental results suggested that CCB could inhibit the growth of PA. CCB might be an effective and interesting antimicrobial treatment strategy as CCB can potentially inhibit the growth of PA." @default.
• W4386020036 created "2023-08-22" @default.
• W4386020036 creator A5008017308 @default.
• W4386020036 creator A5013970397 @default.
• W4386020036 creator A5016057608 @default.
• W4386020036 creator A5017245142 @default.
• W4386020036 creator A5020551868 @default.
• W4386020036 creator A5021766618 @default.
• W4386020036 creator A5048615638 @default.
• W4386020036 creator A5049020512 @default.
• W4386020036 creator A5063660830 @default.
• W4386020036 creator A5068173513 @default.
• W4386020036 date "2023-08-20" @default.
• W4386020036 modified "2023-09-30" @default.
• W4386020036 title "Exploring calcium channel blocker as a candidate drug for <i>Pseudomonas aeruginosa</i> through network pharmacology and experimental validation" @default.
• W4386020036 cites W1905934205 @default.
• W4386020036 cites W1923659714 @default.
• W4386020036 cites W2002442448 @default.
• W4386020036 cites W2024103813 @default.
• W4386020036 cites W2025479210 @default.
• W4386020036 cites W2042475567 @default.
• W4386020036 cites W2049392866 @default.
• W4386020036 cites W2080886752 @default.
• W4386020036 cites W2096173332 @default.
• W4386020036 cites W2098425296 @default.
• W4386020036 cites W2110280725 @default.
• W4386020036 cites W2126125759 @default.
• W4386020036 cites W2159675211 @default.
• W4386020036 cites W2286461931 @default.
• W4386020036 cites W2336841238 @default.
• W4386020036 cites W2408399550 @default.
• W4386020036 cites W2510828985 @default.
• W4386020036 cites W2580962005 @default.
• W4386020036 cites W2592810481 @default.
• W4386020036 cites W2605619367 @default.
• W4386020036 cites W2767278919 @default.
• W4386020036 cites W2767891136 @default.
• W4386020036 cites W2806879449 @default.
• W4386020036 cites W2845957415 @default.
• W4386020036 cites W2883555063 @default.
• W4386020036 cites W2883707477 @default.
• W4386020036 cites W2908995637 @default.
• W4386020036 cites W2964620914 @default.
• W4386020036 cites W2972060813 @default.
• W4386020036 cites W2984106036 @default.
• W4386020036 cites W3030187895 @default.
• W4386020036 cites W3082357516 @default.
• W4386020036 cites W3102032040 @default.
• W4386020036 cites W3102419887 @default.
• W4386020036 cites W3109184006 @default.
• W4386020036 cites W3113307371 @default.
• W4386020036 cites W3119724601 @default.
• W4386020036 cites W3174459050 @default.
• W4386020036 cites W4212823867 @default.
• W4386020036 cites W4231358771 @default.
• W4386020036 doi "https://doi.org/10.1111/cbdd.14322" @default.
• W4386020036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37599112" @default.
• W4386020036 hasPublicationYear "2023" @default.
• W4386020036 type Work @default.
• W4386020036 citedByCount "0" @default.
• W4386020036 crossrefType "journal-article" @default.
• W4386020036 hasAuthorship W4386020036A5008017308 @default.
• W4386020036 hasAuthorship W4386020036A5013970397 @default.
• W4386020036 hasAuthorship W4386020036A5016057608 @default.
• W4386020036 hasAuthorship W4386020036A5017245142 @default.
• W4386020036 hasAuthorship W4386020036A5020551868 @default.
• W4386020036 hasAuthorship W4386020036A5021766618 @default.
• W4386020036 hasAuthorship W4386020036A5048615638 @default.
• W4386020036 hasAuthorship W4386020036A5049020512 @default.
• W4386020036 hasAuthorship W4386020036A5063660830 @default.
• W4386020036 hasAuthorship W4386020036A5068173513 @default.
• W4386020036 hasBestOaLocation W43860200361 @default.
• W4386020036 hasConcept C104317684 @default.
• W4386020036 hasConcept C159110408 @default.
• W4386020036 hasConcept C185592680 @default.
• W4386020036 hasConcept C200082930 @default.
• W4386020036 hasConcept C202264299 @default.
• W4386020036 hasConcept C41685203 @default.
• W4386020036 hasConcept C55493867 @default.
• W4386020036 hasConcept C70721500 @default.
• W4386020036 hasConcept C71924100 @default.
• W4386020036 hasConcept C86803240 @default.
• W4386020036 hasConceptScore W4386020036C104317684 @default.
• W4386020036 hasConceptScore W4386020036C159110408 @default.
• W4386020036 hasConceptScore W4386020036C185592680 @default.
• W4386020036 hasConceptScore W4386020036C200082930 @default.
• W4386020036 hasConceptScore W4386020036C202264299 @default.
• W4386020036 hasConceptScore W4386020036C41685203 @default.
• W4386020036 hasConceptScore W4386020036C55493867 @default.
• W4386020036 hasConceptScore W4386020036C70721500 @default.
• W4386020036 hasConceptScore W4386020036C71924100 @default.
• W4386020036 hasConceptScore W4386020036C86803240 @default.
• W4386020036 hasLocation W43860200361 @default.
• W4386020036 hasLocation W43860200362 @default.
• W4386020036 hasOpenAccess W4386020036 @default.
• W4386020036 hasPrimaryLocation W43860200361 @default.
• W4386020036 hasRelatedWork W2027537503 @default.
• W4386020036 hasRelatedWork W2042493200 @default.
• W4386020036 hasRelatedWork W2159229987 @default.
• W4386020036 hasRelatedWork W2178273593 @default.

• next