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- W4386020924 abstract "Abstract Dysbiosis is linked to autoimmune diseases such as rheumatoid arthritis (RA), where microbial metabolites, such as short chain fatty acids (SCFAs), mediate the so-called gut-joint axis. The therapeutic potential of SCFAs is limited due to the frequent and high oral dosage requirements. RA is characterized by aberrant activation of peripheral T cells and myeloid cells. We aim to deliver butyrate, an SCFA, directly to the lymphatics using a polymeric micelle as a butyrate prodrug, creating a depot for inducing long-lasting immunomodulatory effects. Notably, negatively charged micelles (Neg-ButM) demonstrate superior efficacy in targeting the lymphatics post-subcutaneous administration, and were retained in the draining lymph nodes, spleen, and liver for over a month. In a mouse RA model, we found that Neg-ButM substantially mitigated arthritis symptoms and promoted tolerogenic phenotypes in T cells and myeloid cells, both locally and systemically. These findings suggest potential applications of this approach in treating inflammatory autoimmune diseases." @default.
- W4386020924 created "2023-08-22" @default.
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- W4386020924 date "2023-08-21" @default.
- W4386020924 modified "2023-10-09" @default.
- W4386020924 title "Injectable butyrate-prodrug micelles induce long-acting immune modulation and suppress autoimmune arthritis in mice" @default.
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- W4386020924 doi "https://doi.org/10.1101/2023.08.20.554028" @default.
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