Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386021919> ?p ?o ?g. }
- W4386021919 abstract "Abstract CarH is a coenzyme B 12 -dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B 12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a series of crystal structures of the CarH B 12 -binding domain after illumination suggest formation of unforeseen intermediate states prior to tetramer dissociation. Unexpectedly, in the absence of oxygen, Co-C bond cleavage is followed by reorientation of the corrin ring and a switch from a lower to upper histidine-Co ligation, corresponding to a pentacoordinate state. Under aerobic conditions, rapid flash-cooling of crystals prior to deterioration upon illumination confirm a similar B 12 -ligand switch occurs. Removal of the upper His-ligating residue prevents monomer formation upon illumination. Combined with detailed solution spectroscopy and computational studies, these data demonstrate the CarH photoresponse integrates B 12 photo- and redox-chemistry to drive large-scale conformational changes through stepwise Co-ligation changes." @default.
- W4386021919 created "2023-08-22" @default.
- W4386021919 creator A5002683913 @default.
- W4386021919 creator A5004792265 @default.
- W4386021919 creator A5014213324 @default.
- W4386021919 creator A5018819443 @default.
- W4386021919 creator A5024197542 @default.
- W4386021919 creator A5028841623 @default.
- W4386021919 creator A5033158786 @default.
- W4386021919 creator A5042512565 @default.
- W4386021919 creator A5047614443 @default.
- W4386021919 creator A5059752371 @default.
- W4386021919 creator A5066313809 @default.
- W4386021919 creator A5073198689 @default.
- W4386021919 creator A5076493204 @default.
- W4386021919 creator A5078254580 @default.
- W4386021919 creator A5091296060 @default.
- W4386021919 creator A5092806796 @default.
- W4386021919 date "2023-08-21" @default.
- W4386021919 modified "2023-10-06" @default.
- W4386021919 title "Redox driven B12-ligand switch drives CarH photoresponse" @default.
- W4386021919 cites W1194791285 @default.
- W4386021919 cites W1592165824 @default.
- W4386021919 cites W1748868217 @default.
- W4386021919 cites W1855881744 @default.
- W4386021919 cites W1971882267 @default.
- W4386021919 cites W1987468043 @default.
- W4386021919 cites W2001998436 @default.
- W4386021919 cites W2004032200 @default.
- W4386021919 cites W2008728209 @default.
- W4386021919 cites W2013036895 @default.
- W4386021919 cites W2016101261 @default.
- W4386021919 cites W2047399603 @default.
- W4386021919 cites W2065403922 @default.
- W4386021919 cites W2072631366 @default.
- W4386021919 cites W2091208703 @default.
- W4386021919 cites W2119116665 @default.
- W4386021919 cites W2124026197 @default.
- W4386021919 cites W2131417105 @default.
- W4386021919 cites W2144998676 @default.
- W4386021919 cites W2146051607 @default.
- W4386021919 cites W2159211495 @default.
- W4386021919 cites W2159987685 @default.
- W4386021919 cites W2164382089 @default.
- W4386021919 cites W2386990068 @default.
- W4386021919 cites W2406215274 @default.
- W4386021919 cites W2463368123 @default.
- W4386021919 cites W2530189632 @default.
- W4386021919 cites W2580833673 @default.
- W4386021919 cites W2619320260 @default.
- W4386021919 cites W2731784911 @default.
- W4386021919 cites W2790057789 @default.
- W4386021919 cites W2793340274 @default.
- W4386021919 cites W2796912840 @default.
- W4386021919 cites W2893511634 @default.
- W4386021919 cites W2921388772 @default.
- W4386021919 cites W2951184079 @default.
- W4386021919 cites W2955024447 @default.
- W4386021919 cites W2973457155 @default.
- W4386021919 cites W3083406432 @default.
- W4386021919 cites W3091856812 @default.
- W4386021919 cites W3100429678 @default.
- W4386021919 cites W3112623569 @default.
- W4386021919 cites W3155907935 @default.
- W4386021919 cites W3159391491 @default.
- W4386021919 cites W3172932458 @default.
- W4386021919 cites W4200051300 @default.
- W4386021919 cites W4210315774 @default.
- W4386021919 cites W4220756218 @default.
- W4386021919 cites W4311138744 @default.
- W4386021919 doi "https://doi.org/10.1038/s41467-023-40817-6" @default.
- W4386021919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37604813" @default.
- W4386021919 hasPublicationYear "2023" @default.
- W4386021919 type Work @default.
- W4386021919 citedByCount "0" @default.
- W4386021919 crossrefType "journal-article" @default.
- W4386021919 hasAuthorship W4386021919A5002683913 @default.
- W4386021919 hasAuthorship W4386021919A5004792265 @default.
- W4386021919 hasAuthorship W4386021919A5014213324 @default.
- W4386021919 hasAuthorship W4386021919A5018819443 @default.
- W4386021919 hasAuthorship W4386021919A5024197542 @default.
- W4386021919 hasAuthorship W4386021919A5028841623 @default.
- W4386021919 hasAuthorship W4386021919A5033158786 @default.
- W4386021919 hasAuthorship W4386021919A5042512565 @default.
- W4386021919 hasAuthorship W4386021919A5047614443 @default.
- W4386021919 hasAuthorship W4386021919A5059752371 @default.
- W4386021919 hasAuthorship W4386021919A5066313809 @default.
- W4386021919 hasAuthorship W4386021919A5073198689 @default.
- W4386021919 hasAuthorship W4386021919A5076493204 @default.
- W4386021919 hasAuthorship W4386021919A5078254580 @default.
- W4386021919 hasAuthorship W4386021919A5091296060 @default.
- W4386021919 hasAuthorship W4386021919A5092806796 @default.
- W4386021919 hasBestOaLocation W43860219191 @default.
- W4386021919 hasConcept C102931765 @default.
- W4386021919 hasConcept C116569031 @default.
- W4386021919 hasConcept C12554922 @default.
- W4386021919 hasConcept C147789679 @default.
- W4386021919 hasConcept C159985019 @default.
- W4386021919 hasConcept C161790260 @default.
- W4386021919 hasConcept C166940927 @default.