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- W4386021959 abstract "Artificial cells are biomimetic structures formed from molecular building blocks that replicate biological processes, behaviors, and architectures. Of these building blocks, hydrogels have emerged as ideal, yet underutilized candidates to provide a gel-like chassis in which to incorporate both biological and nonbiological componentry which enables the replication of cellular functionality. Here, we demonstrate a microfluidic strategy to assemble biocompatible cell-sized hydrogel-based artificial cells with a variety of different embedded functional subcompartments, which act as engineered synthetic organelles. The organelles enable the recreation of increasingly biomimetic behaviors, including stimulus-induced motility, content release through activation of membrane-associated proteins, and enzymatic communication with surrounding bioinspired compartments. In this way, we showcase a foundational strategy for the bottom–up construction of hydrogel-based artificial cell microsystems which replicate fundamental cellular behaviors, paving the way for the construction of next-generation biotechnological devices." @default.
- W4386021959 created "2023-08-22" @default.
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- W4386021959 date "2023-08-21" @default.
- W4386021959 modified "2023-09-26" @default.
- W4386021959 title "Biomimetic behaviors in hydrogel artificial cells through embedded organelles" @default.
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- W4386021959 doi "https://doi.org/10.1073/pnas.2307772120" @default.
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