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- W4386026484 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Senescent cells are characterized by an arrest in proliferation. In addition to replicative senescence resulting from telomere exhaustion, sub-lethal genotoxic stress resulting from DNA damage, oncogene activation or mitochondrial dysfunction also elicits a senescence phenotype.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Senescence was induced in an osteocarcinoma cancer cell line in response to sub-lethal doses of a genotoxic chemotherapeutic agent, followed by quantitative SWATH proteomics and RNA-seq analyses.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>We present here an integrative multi-omic analysis of proteomic and RNA-seq from proliferating and senescent osteosarcoma cells. Senescence is a controlled program affecting a wide variety of biological processes with some core hallmarks of senescence as well as cell type specific changes.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> This study presents an integrated analysis and makes available both RNA-seq and proteomic data from proliferating and senescent cells in appropriate FAIR data repositories to aid reuse by the community.</ns4:p>" @default.
- W4386026484 created "2023-08-22" @default.
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- W4386026484 date "2023-08-21" @default.
- W4386026484 modified "2023-09-26" @default.
- W4386026484 title "An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line" @default.
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- W4386026484 doi "https://doi.org/10.12688/f1000research.133203.1" @default.
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