Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386027899> ?p ?o ?g. }
- W4386027899 abstract "Abstract Recent studies have shown that amphoteric regulatory protein (AREG), a member of the epidermal growth factor (EGF) family, is expressed in many cancers and is an independent prognostic indicator for patients with pancreatic cancer, but whether AREG is regulated at the epigenetic level to promote the development of pancreatic cancer (PC) has not been elucidated. Our results support the notion that AREG is overexpressed in pancreatic cancer tissues and cell lines. Functionally, the deletion of AREG impedes pancreatic cancer (PC) cell proliferation, migration, and invasion. In addition, we identified and validated that methyltransferase-like 3 (METTL3) induced the m 6 A modification on AREG and facilitated the stability of AREG mRNA after sequencing. Additionally, we obtained experimental evidence that miR-33a-3p targets and inhibits METTL3 from taking action, as predicted by using the miRDB and RNAinter. Remediation experiments showed that miR-33a-3p inhibits PC progression through METTL3. In summary, this research reveals that miR-33a-3p inhibits m 6 A-induced stabilization of AREG by targeting METTL3, which plays a key role in the aggressive progression of PC. AREG could be a potential target for PC treatment." @default.
- W4386027899 created "2023-08-22" @default.
- W4386027899 creator A5008924675 @default.
- W4386027899 creator A5020383361 @default.
- W4386027899 creator A5041668848 @default.
- W4386027899 creator A5048237545 @default.
- W4386027899 creator A5057945634 @default.
- W4386027899 creator A5059456911 @default.
- W4386027899 creator A5059560573 @default.
- W4386027899 creator A5063088837 @default.
- W4386027899 creator A5064222660 @default.
- W4386027899 creator A5065124683 @default.
- W4386027899 creator A5074880411 @default.
- W4386027899 creator A5082924617 @default.
- W4386027899 date "2023-08-21" @default.
- W4386027899 modified "2023-09-26" @default.
- W4386027899 title "miR-33a-3p regulates METTL3-mediated AREG stability and alters EMT to inhibit pancreatic cancer invasion and metastasis" @default.
- W4386027899 cites W2006548076 @default.
- W4386027899 cites W2078964320 @default.
- W4386027899 cites W2091724447 @default.
- W4386027899 cites W2164942973 @default.
- W4386027899 cites W2413475456 @default.
- W4386027899 cites W2592704775 @default.
- W4386027899 cites W2610956165 @default.
- W4386027899 cites W2627064270 @default.
- W4386027899 cites W2767546566 @default.
- W4386027899 cites W2768332833 @default.
- W4386027899 cites W2800459978 @default.
- W4386027899 cites W2922969171 @default.
- W4386027899 cites W2923641375 @default.
- W4386027899 cites W2977905919 @default.
- W4386027899 cites W2991007821 @default.
- W4386027899 cites W3006726284 @default.
- W4386027899 cites W3010560689 @default.
- W4386027899 cites W3087375045 @default.
- W4386027899 cites W3120289854 @default.
- W4386027899 cites W3133117790 @default.
- W4386027899 cites W3157902236 @default.
- W4386027899 cites W3170298308 @default.
- W4386027899 cites W3189047529 @default.
- W4386027899 cites W3203743095 @default.
- W4386027899 cites W3208079090 @default.
- W4386027899 cites W4200064844 @default.
- W4386027899 cites W4206841660 @default.
- W4386027899 cites W4206985912 @default.
- W4386027899 cites W4212855920 @default.
- W4386027899 cites W4213335472 @default.
- W4386027899 cites W4224290395 @default.
- W4386027899 cites W4292980283 @default.
- W4386027899 doi "https://doi.org/10.1038/s41598-023-39506-7" @default.
- W4386027899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37604948" @default.
- W4386027899 hasPublicationYear "2023" @default.
- W4386027899 type Work @default.
- W4386027899 citedByCount "0" @default.
- W4386027899 crossrefType "journal-article" @default.
- W4386027899 hasAuthorship W4386027899A5008924675 @default.
- W4386027899 hasAuthorship W4386027899A5020383361 @default.
- W4386027899 hasAuthorship W4386027899A5041668848 @default.
- W4386027899 hasAuthorship W4386027899A5048237545 @default.
- W4386027899 hasAuthorship W4386027899A5057945634 @default.
- W4386027899 hasAuthorship W4386027899A5059456911 @default.
- W4386027899 hasAuthorship W4386027899A5059560573 @default.
- W4386027899 hasAuthorship W4386027899A5063088837 @default.
- W4386027899 hasAuthorship W4386027899A5064222660 @default.
- W4386027899 hasAuthorship W4386027899A5065124683 @default.
- W4386027899 hasAuthorship W4386027899A5074880411 @default.
- W4386027899 hasAuthorship W4386027899A5082924617 @default.
- W4386027899 hasBestOaLocation W43860278991 @default.
- W4386027899 hasConcept C104317684 @default.
- W4386027899 hasConcept C121608353 @default.
- W4386027899 hasConcept C126322002 @default.
- W4386027899 hasConcept C143998085 @default.
- W4386027899 hasConcept C170493617 @default.
- W4386027899 hasConcept C2776362946 @default.
- W4386027899 hasConcept C2779013556 @default.
- W4386027899 hasConcept C2780210213 @default.
- W4386027899 hasConcept C41091548 @default.
- W4386027899 hasConcept C502942594 @default.
- W4386027899 hasConcept C55493867 @default.
- W4386027899 hasConcept C71924100 @default.
- W4386027899 hasConcept C86803240 @default.
- W4386027899 hasConceptScore W4386027899C104317684 @default.
- W4386027899 hasConceptScore W4386027899C121608353 @default.
- W4386027899 hasConceptScore W4386027899C126322002 @default.
- W4386027899 hasConceptScore W4386027899C143998085 @default.
- W4386027899 hasConceptScore W4386027899C170493617 @default.
- W4386027899 hasConceptScore W4386027899C2776362946 @default.
- W4386027899 hasConceptScore W4386027899C2779013556 @default.
- W4386027899 hasConceptScore W4386027899C2780210213 @default.
- W4386027899 hasConceptScore W4386027899C41091548 @default.
- W4386027899 hasConceptScore W4386027899C502942594 @default.
- W4386027899 hasConceptScore W4386027899C55493867 @default.
- W4386027899 hasConceptScore W4386027899C71924100 @default.
- W4386027899 hasConceptScore W4386027899C86803240 @default.
- W4386027899 hasIssue "1" @default.
- W4386027899 hasLocation W43860278991 @default.
- W4386027899 hasLocation W43860278992 @default.
- W4386027899 hasOpenAccess W4386027899 @default.
- W4386027899 hasPrimaryLocation W43860278991 @default.
- W4386027899 hasRelatedWork W1499339123 @default.