FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386028567> ?p ?o ?g. }

• W4386028567 endingPage "18" @default.
• W4386028567 startingPage "13" @default.
• W4386028567 abstract "Objective : To study the frequency of spontaneous foci of DNA double-strand breaks (DSBs) in patients with immune-inflammatory rheumatic diseases (IIRD), their relationship to disease activity, levels of inflammatory markers, and levels of autoantibodies. Material and methods . The analysis included 40 patients with IIRD, including 19 patients with rheumatoid arthritis (RA, including 16 women, median disease duration 60 [20; 103] months, DAS28 was 5.05 [4.06; 5.9]) and 21 patients with systemic lupus erythematosus (SLE, 19 women, median disease duration 96.0 [40.0; 158.0] months, SLEDAI-2K 8.0 [4.0; 12.0]). The control group consisted of 17 healthy donors matched for sex and age. DNA DSBs were identified as discrete foci by immunofluorescence staining of lymphocyte cultures with antibodies against γH2AX and 53BP1 and subsequently analysed using the automated AKLIDES automated platform (Medipan). Results and discussion . There were no significant differences in the number of spontaneous DNA DSBs in patients with RA and healthy donors (p>0.05), a lower number of cells with the 53BP1 focus and a lower percentage of cells damaged in this focus were found in patients with SLE than in controls. There was a positive correlation between the number of γH2AXdamaged cells and CDAI(r=0.45, p=0.035), the number of cells with 53BP1 ruptures and the level of rheumatoid factor IgM (r=0.63, p=0.005) and ESR (r=0.53, p=0.02). In the group of SLE patients, a positive correlation was observed between the number of cells with breaks in the γH2AX focus and the level of antibodies against double-stranded DNA (anti-dsDNA; r=0.56, p=0.007), the average number of breaks in the cell in the γH2AX focus with the level of anti-dsDNA (r=0.57, p=0.004). Conclusion . The number of DNA DSBs may be an additional indicator of IIRD activity. In patients with SLE, DNA repair processes appear to be impaired, which is associated with the high activity of the disease." @default.
• W4386028567 created "2023-08-22" @default.
• W4386028567 creator A5001854360 @default.
• W4386028567 creator A5004963520 @default.
• W4386028567 creator A5022097092 @default.
• W4386028567 creator A5071594707 @default.
• W4386028567 creator A5073796892 @default.
• W4386028567 creator A5079511652 @default.
• W4386028567 creator A5080646343 @default.
• W4386028567 creator A5084995733 @default.
• W4386028567 creator A5085739568 @default.
• W4386028567 creator A5092668324 @default.
• W4386028567 date "2023-08-20" @default.
• W4386028567 modified "2023-10-03" @default.
• W4386028567 title "DNA double-strand breaks in immunoinflammatory rheumatic diseases" @default.
• W4386028567 cites W110294243 @default.
• W4386028567 cites W121884295 @default.
• W4386028567 cites W1973874596 @default.
• W4386028567 cites W2016668533 @default.
• W4386028567 cites W2019405732 @default.
• W4386028567 cites W2039143648 @default.
• W4386028567 cites W2065379807 @default.
• W4386028567 cites W2074537013 @default.
• W4386028567 cites W2078713085 @default.
• W4386028567 cites W2116054786 @default.
• W4386028567 cites W2138055529 @default.
• W4386028567 cites W2142460487 @default.
• W4386028567 cites W2152745581 @default.
• W4386028567 cites W2159213304 @default.
• W4386028567 cites W2170076954 @default.
• W4386028567 cites W2217722934 @default.
• W4386028567 cites W2344613336 @default.
• W4386028567 cites W2352719856 @default.
• W4386028567 cites W2498501382 @default.
• W4386028567 cites W2575581333 @default.
• W4386028567 cites W2607987923 @default.
• W4386028567 cites W2885738092 @default.
• W4386028567 cites W2994985094 @default.
• W4386028567 cites W3092300183 @default.
• W4386028567 cites W3151136479 @default.
• W4386028567 cites W3186417846 @default.
• W4386028567 cites W3196974299 @default.
• W4386028567 cites W3199338586 @default.
• W4386028567 cites W4297914794 @default.
• W4386028567 cites W4319437567 @default.
• W4386028567 doi "https://doi.org/10.14412/1996-7012-2023-4-13-18" @default.
• W4386028567 hasPublicationYear "2023" @default.
• W4386028567 type Work @default.
• W4386028567 citedByCount "0" @default.
• W4386028567 crossrefType "journal-article" @default.
• W4386028567 hasAuthorship W4386028567A5001854360 @default.
• W4386028567 hasAuthorship W4386028567A5004963520 @default.
• W4386028567 hasAuthorship W4386028567A5022097092 @default.
• W4386028567 hasAuthorship W4386028567A5071594707 @default.
• W4386028567 hasAuthorship W4386028567A5073796892 @default.
• W4386028567 hasAuthorship W4386028567A5079511652 @default.
• W4386028567 hasAuthorship W4386028567A5080646343 @default.
• W4386028567 hasAuthorship W4386028567A5084995733 @default.
• W4386028567 hasAuthorship W4386028567A5085739568 @default.
• W4386028567 hasAuthorship W4386028567A5092668324 @default.
• W4386028567 hasBestOaLocation W43860285671 @default.
• W4386028567 hasConcept C126322002 @default.
• W4386028567 hasConcept C159654299 @default.
• W4386028567 hasConcept C163764329 @default.
• W4386028567 hasConcept C198451711 @default.
• W4386028567 hasConcept C203014093 @default.
• W4386028567 hasConcept C2776232647 @default.
• W4386028567 hasConcept C2777077863 @default.
• W4386028567 hasConcept C2777575956 @default.
• W4386028567 hasConcept C2778236600 @default.
• W4386028567 hasConcept C2779075594 @default.
• W4386028567 hasConcept C2780380361 @default.
• W4386028567 hasConcept C71924100 @default.
• W4386028567 hasConcept C8891405 @default.
• W4386028567 hasConceptScore W4386028567C126322002 @default.
• W4386028567 hasConceptScore W4386028567C159654299 @default.
• W4386028567 hasConceptScore W4386028567C163764329 @default.
• W4386028567 hasConceptScore W4386028567C198451711 @default.
• W4386028567 hasConceptScore W4386028567C203014093 @default.
• W4386028567 hasConceptScore W4386028567C2776232647 @default.
• W4386028567 hasConceptScore W4386028567C2777077863 @default.
• W4386028567 hasConceptScore W4386028567C2777575956 @default.
• W4386028567 hasConceptScore W4386028567C2778236600 @default.
• W4386028567 hasConceptScore W4386028567C2779075594 @default.
• W4386028567 hasConceptScore W4386028567C2780380361 @default.
• W4386028567 hasConceptScore W4386028567C71924100 @default.
• W4386028567 hasConceptScore W4386028567C8891405 @default.
• W4386028567 hasIssue "4" @default.
• W4386028567 hasLocation W43860285671 @default.
• W4386028567 hasOpenAccess W4386028567 @default.
• W4386028567 hasPrimaryLocation W43860285671 @default.
• W4386028567 hasRelatedWork W182203678 @default.
• W4386028567 hasRelatedWork W1980206759 @default.
• W4386028567 hasRelatedWork W1999301958 @default.
• W4386028567 hasRelatedWork W2048718416 @default.
• W4386028567 hasRelatedWork W2101875571 @default.
• W4386028567 hasRelatedWork W2121829054 @default.
• W4386028567 hasRelatedWork W2325128807 @default.

• next