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- W4386029490 abstract "ATP is an abundant molecule with crucial cellular roles as the energy currency and a building block of nucleic acids and for protein phosphorylation. Here we show that ATP mediates the phase separation of basic intrinsically disordered proteins (bIDPs). In the resulting condensates, ATP is highly concentrated (apparent partition coefficients at 200-5000) and serves as bridges between bIDP chains. These liquid-like droplets have some of the lowest interfacial tension (∼25 pN/μm) but high zero-shear viscosities (1-15 Pa s) due to the bridged protein networks, and yet their fusion has some of the highest speeds (∼1 μm/ms). The rapid fusion manifests extreme shear thinning, where the apparent viscosity is lower than zero-shear viscosity by over 100-fold, made possible by fast reformation of the ATP bridges. At still higher concentrations, ATP does not dissolve bIDP droplets but results in aggregates and fibrils." @default.
- W4386029490 created "2023-08-22" @default.
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- W4386029490 date "2023-08-20" @default.
- W4386029490 modified "2023-10-09" @default.
- W4386029490 title "ATP Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks" @default.
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- W4386029490 doi "https://doi.org/10.1101/2023.08.20.554035" @default.
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