Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386030208> ?p ?o ?g. }
- W4386030208 endingPage "433" @default.
- W4386030208 startingPage "397" @default.
- W4386030208 abstract "Drugs are prescribed worldwide to treat diseases but with the risk of idiosyncratic drug-induced liver injury (iDILI). The most important difficulty is how best to establish causality. Based on strong evidence and principles of artificial intelligence (AI) to solve complex processes through quantitative algorithms using scored elements, progress was achieved with the Roussel Uclaf Causality Assessment Method (RUCAM) in its original and updated versions, often viewed now as the gold standard. As a highly appreciated diagnostic algorithm, the RUCAM is in global use with around 100,000 iDILI cases published worldwide using RUCAM to assess causality, largely outperforming any other specific causality assessment tool in terms of case numbers. Consequently, the RUCAM helps to establish a list of top-ranking drugs worldwide implicated in iDILI and to describe clinical and mechanistic features of iDILI caused by various drugs. In addition, the RUCAM was recently applied in iDILI cases of patients treated for coronavirus disease 2019 (COVID-19) infections or cancer patients treated with immune checkpoint inhibitors (ICIs), as well as in the search for new treatment options with conventional drugs in iDILI. Analyses of RUCAM-based iDILI cases are helpful to support pathogenetic steps like immune reactions, genetic predisposition as evidenced by human leucocyte antigens (HLA) genotypes for selected drugs, and the role of the gut microbiome. To achieve consistency in data collection, analysis, and specific clinical and pathogenetic presentation, researchers, regulatory agencies, and pharmaceutical firms should place iDILI and the updated RUCAM as the causality tool under one and the same hat in review articles and clinical guidelines for the diagnosis and treatment of iDILI." @default.
- W4386030208 created "2023-08-22" @default.
- W4386030208 creator A5019675536 @default.
- W4386030208 creator A5033658778 @default.
- W4386030208 date "2023-08-19" @default.
- W4386030208 modified "2023-09-26" @default.
- W4386030208 title "Idiosyncratic DILI and RUCAM under One Hat: The Global View" @default.
- W4386030208 cites W1508165093 @default.
- W4386030208 cites W1839251276 @default.
- W4386030208 cites W1843112576 @default.
- W4386030208 cites W1853122476 @default.
- W4386030208 cites W1923117400 @default.
- W4386030208 cites W1963741464 @default.
- W4386030208 cites W1964694228 @default.
- W4386030208 cites W1966268750 @default.
- W4386030208 cites W1967592761 @default.
- W4386030208 cites W1969780974 @default.
- W4386030208 cites W1973130325 @default.
- W4386030208 cites W1974731268 @default.
- W4386030208 cites W1975417903 @default.
- W4386030208 cites W1975440270 @default.
- W4386030208 cites W1977203090 @default.
- W4386030208 cites W1979437648 @default.
- W4386030208 cites W1986005428 @default.
- W4386030208 cites W1994027124 @default.
- W4386030208 cites W1995546772 @default.
- W4386030208 cites W1997435071 @default.
- W4386030208 cites W1998416434 @default.
- W4386030208 cites W1999654726 @default.
- W4386030208 cites W2002493942 @default.
- W4386030208 cites W2003268732 @default.
- W4386030208 cites W2004009551 @default.
- W4386030208 cites W2010825865 @default.
- W4386030208 cites W2013756572 @default.
- W4386030208 cites W2026969166 @default.
- W4386030208 cites W2032567331 @default.
- W4386030208 cites W2048292471 @default.
- W4386030208 cites W2059202845 @default.
- W4386030208 cites W2060070314 @default.
- W4386030208 cites W2089000602 @default.
- W4386030208 cites W2089424112 @default.
- W4386030208 cites W2089707005 @default.
- W4386030208 cites W2100990289 @default.
- W4386030208 cites W2104369321 @default.
- W4386030208 cites W2106934241 @default.
- W4386030208 cites W2110251992 @default.
- W4386030208 cites W2113183888 @default.
- W4386030208 cites W2132901471 @default.
- W4386030208 cites W2157791560 @default.
- W4386030208 cites W2159924934 @default.
- W4386030208 cites W2160736876 @default.
- W4386030208 cites W2163961396 @default.
- W4386030208 cites W2168538436 @default.
- W4386030208 cites W2169441188 @default.
- W4386030208 cites W2170799413 @default.
- W4386030208 cites W2176031852 @default.
- W4386030208 cites W2194890007 @default.
- W4386030208 cites W2196921079 @default.
- W4386030208 cites W2218985750 @default.
- W4386030208 cites W2223803148 @default.
- W4386030208 cites W2253523184 @default.
- W4386030208 cites W2271251932 @default.
- W4386030208 cites W2293780689 @default.
- W4386030208 cites W2316627597 @default.
- W4386030208 cites W2332712159 @default.
- W4386030208 cites W2395312093 @default.
- W4386030208 cites W2421676640 @default.
- W4386030208 cites W24473064 @default.
- W4386030208 cites W2473218705 @default.
- W4386030208 cites W2513004825 @default.
- W4386030208 cites W2522770318 @default.
- W4386030208 cites W2527498163 @default.
- W4386030208 cites W2566636187 @default.
- W4386030208 cites W2586003650 @default.
- W4386030208 cites W2591181891 @default.
- W4386030208 cites W2606888484 @default.
- W4386030208 cites W2607197422 @default.
- W4386030208 cites W2614780060 @default.
- W4386030208 cites W2744185094 @default.
- W4386030208 cites W2750881983 @default.
- W4386030208 cites W2766183371 @default.
- W4386030208 cites W2769751863 @default.
- W4386030208 cites W2783137027 @default.
- W4386030208 cites W2786710826 @default.
- W4386030208 cites W2788726176 @default.
- W4386030208 cites W2790306609 @default.
- W4386030208 cites W2796461907 @default.
- W4386030208 cites W2804707254 @default.
- W4386030208 cites W2808573197 @default.
- W4386030208 cites W2810015746 @default.
- W4386030208 cites W2825973698 @default.
- W4386030208 cites W2884650974 @default.
- W4386030208 cites W2888285761 @default.
- W4386030208 cites W2897373916 @default.
- W4386030208 cites W2901966843 @default.
- W4386030208 cites W2910972432 @default.
- W4386030208 cites W2913254552 @default.
- W4386030208 cites W2914750127 @default.