Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386031922> ?p ?o ?g. }
- W4386031922 endingPage "2112" @default.
- W4386031922 startingPage "2112" @default.
- W4386031922 abstract "The anti-inflammatory effects of depolymerizing microtubule-targeting agents on leukocytes are known for a long time, but the potential involvement of the vascular endothelium and the underlying mechanistic basis is still largely unclear. Using the recently synthesized depolymerizing microtubule-targeting agent pretubulysin, we investigated the anti-inflammatory potential of pretubulysin and other microtubule-targeting agents with respect to the TNF-induced leukocyte adhesion cascade in endothelial cells, to improve our understanding of the underlying biomolecular background. We found that treatment with pretubulysin reduces inflammation in vivo and in vitro via inhibition of the TNF-induced adhesion of leukocytes to the vascular endothelium by down-regulation of the pro-inflammatory cell adhesion molecules ICAM-1 and VCAM-1 in a JNK-dependent manner. The underlying mechanism includes JNK-induced deregulation and degradation of the histone acetyltransferase Bromodomain-containing protein 4. This study shows that depolymerizing microtubule-targeting agents, in addition to their established effects on leukocytes, also significantly decrease the inflammatory activation of vascular endothelial cells. These effects are not based on altered pro-inflammatory signaling cascades, but require deregulation of the capability of cells to enter constructive transcription for some genes, setting a baseline for further research on the prominent anti-inflammatory effects of depolymerizing microtubule-targeting agents." @default.
- W4386031922 created "2023-08-22" @default.
- W4386031922 creator A5000541724 @default.
- W4386031922 creator A5012317748 @default.
- W4386031922 creator A5014483690 @default.
- W4386031922 creator A5032227105 @default.
- W4386031922 creator A5041705287 @default.
- W4386031922 creator A5051832102 @default.
- W4386031922 creator A5055195276 @default.
- W4386031922 creator A5062706737 @default.
- W4386031922 creator A5083473328 @default.
- W4386031922 creator A5088253534 @default.
- W4386031922 creator A5090409082 @default.
- W4386031922 date "2023-08-21" @default.
- W4386031922 modified "2023-10-18" @default.
- W4386031922 title "The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4" @default.
- W4386031922 cites W1153335416 @default.
- W4386031922 cites W1489957431 @default.
- W4386031922 cites W1619185285 @default.
- W4386031922 cites W1939997832 @default.
- W4386031922 cites W1979129905 @default.
- W4386031922 cites W1995332924 @default.
- W4386031922 cites W1996894556 @default.
- W4386031922 cites W1998812648 @default.
- W4386031922 cites W2014359667 @default.
- W4386031922 cites W2029703851 @default.
- W4386031922 cites W2048520623 @default.
- W4386031922 cites W2053889157 @default.
- W4386031922 cites W2059797575 @default.
- W4386031922 cites W2063208932 @default.
- W4386031922 cites W2078320770 @default.
- W4386031922 cites W2085199146 @default.
- W4386031922 cites W2094654932 @default.
- W4386031922 cites W2107277218 @default.
- W4386031922 cites W2108425728 @default.
- W4386031922 cites W2110078458 @default.
- W4386031922 cites W2128743891 @default.
- W4386031922 cites W2135503594 @default.
- W4386031922 cites W2135919238 @default.
- W4386031922 cites W2137725057 @default.
- W4386031922 cites W2139162294 @default.
- W4386031922 cites W2140765582 @default.
- W4386031922 cites W2152979497 @default.
- W4386031922 cites W2154180011 @default.
- W4386031922 cites W2155081197 @default.
- W4386031922 cites W2157603347 @default.
- W4386031922 cites W2192080449 @default.
- W4386031922 cites W2339918155 @default.
- W4386031922 cites W2473173223 @default.
- W4386031922 cites W2515697377 @default.
- W4386031922 cites W2737388023 @default.
- W4386031922 cites W2750829881 @default.
- W4386031922 cites W2900858012 @default.
- W4386031922 cites W2993908729 @default.
- W4386031922 cites W3000196031 @default.
- W4386031922 cites W3012209739 @default.
- W4386031922 cites W3076283988 @default.
- W4386031922 cites W3109747389 @default.
- W4386031922 cites W3214351896 @default.
- W4386031922 cites W4283789515 @default.
- W4386031922 doi "https://doi.org/10.3390/cells12162112" @default.
- W4386031922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37626922" @default.
- W4386031922 hasPublicationYear "2023" @default.
- W4386031922 type Work @default.
- W4386031922 citedByCount "0" @default.
- W4386031922 crossrefType "journal-article" @default.
- W4386031922 hasAuthorship W4386031922A5000541724 @default.
- W4386031922 hasAuthorship W4386031922A5012317748 @default.
- W4386031922 hasAuthorship W4386031922A5014483690 @default.
- W4386031922 hasAuthorship W4386031922A5032227105 @default.
- W4386031922 hasAuthorship W4386031922A5041705287 @default.
- W4386031922 hasAuthorship W4386031922A5051832102 @default.
- W4386031922 hasAuthorship W4386031922A5055195276 @default.
- W4386031922 hasAuthorship W4386031922A5062706737 @default.
- W4386031922 hasAuthorship W4386031922A5083473328 @default.
- W4386031922 hasAuthorship W4386031922A5088253534 @default.
- W4386031922 hasAuthorship W4386031922A5090409082 @default.
- W4386031922 hasBestOaLocation W43860319221 @default.
- W4386031922 hasConcept C104317684 @default.
- W4386031922 hasConcept C119056186 @default.
- W4386031922 hasConcept C185592680 @default.
- W4386031922 hasConcept C203014093 @default.
- W4386031922 hasConcept C20418707 @default.
- W4386031922 hasConcept C2776914184 @default.
- W4386031922 hasConcept C2776992346 @default.
- W4386031922 hasConcept C502942594 @default.
- W4386031922 hasConcept C54355233 @default.
- W4386031922 hasConcept C55493867 @default.
- W4386031922 hasConcept C64927066 @default.
- W4386031922 hasConcept C74401373 @default.
- W4386031922 hasConcept C86803240 @default.
- W4386031922 hasConcept C95444343 @default.
- W4386031922 hasConceptScore W4386031922C104317684 @default.
- W4386031922 hasConceptScore W4386031922C119056186 @default.
- W4386031922 hasConceptScore W4386031922C185592680 @default.
- W4386031922 hasConceptScore W4386031922C203014093 @default.
- W4386031922 hasConceptScore W4386031922C20418707 @default.
- W4386031922 hasConceptScore W4386031922C2776914184 @default.