FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386032323> ?p ?o ?g. }

• W4386032323 abstract "Background lung adenocarcinoma (LUAD) remains one of the most common and lethal malignancies with poor prognosis. Programmed cell death (PCD) is an evolutionarily conserved cell suicide process that regulates tumorigenesis, progression, and metastasis of cancer cells. However, a comprehensive analysis of the role of PCD in LUAD is still unavailable. Methods We analyzed multi-omic variations in PCD-related genes (PCDRGs) for LUAD. We used cross-validation of 10 machine learning algorithms (101 combinations) to synthetically develop and validate an optimal prognostic cell death score (CDS) model based on the PCDRGs expression profile. Patients were classified based on their median CDS values into the high and low-CDS groups. Next, we compared the differences in the genomics, biological functions, and tumor microenvironment of patients between both groups. In addition, we assessed the ability of CDS for predicting the response of patients from the immunotherapy cohort to immunotherapy. Finally, functional validation of key genes in CDS was performed. Results We constructed CDS based on four PCDRGs, which could effectively and consistently stratify patients with LUAD (patients with high CDS had poor prognoses). The performance of our CDS was superior compared to 77 LUAD signatures that have been previously published. The results revealed significant genetic alterations like mutation count, TMB, and CNV were observed in patients with high CDS. Furthermore, we observed an association of CDS with immune cell infiltration, microsatellite instability, SNV neoantigens. The immune status of patients with low CDS was more active. In addition, CDS could be reliable to predict therapeutic response in multiple immunotherapy cohorts. In vitro experiments revealed that high DNA damage inducible transcript 4 ( DDIT4 ) expression in LUAD cells mediated protumor effects. Conclusion CDS was constructed based on PCDRGs using machine learning. This model could accurately predict patients’ prognoses and their responses to therapy. These results provide new promising tools for clinical management and aid in designing personalized treatment strategies for patients with LUAD." @default.
• W4386032323 created "2023-08-22" @default.
• W4386032323 creator A5008923395 @default.
• W4386032323 creator A5017204952 @default.
• W4386032323 creator A5034029120 @default.
• W4386032323 creator A5035557906 @default.
• W4386032323 creator A5044544424 @default.
• W4386032323 date "2023-08-21" @default.
• W4386032323 modified "2023-09-27" @default.
• W4386032323 title "A programmed cell death-related model based on machine learning for predicting prognosis and immunotherapy responses in patients with lung adenocarcinoma" @default.
• W4386032323 cites W123945449 @default.
• W4386032323 cites W1607261149 @default.
• W4386032323 cites W1864325817 @default.
• W4386032323 cites W1882905539 @default.
• W4386032323 cites W1903960893 @default.
• W4386032323 cites W1940241680 @default.
• W4386032323 cites W1964307104 @default.
• W4386032323 cites W1970633843 @default.
• W4386032323 cites W1977859620 @default.
• W4386032323 cites W1989051519 @default.
• W4386032323 cites W1999213748 @default.
• W4386032323 cites W2008634667 @default.
• W4386032323 cites W2010949872 @default.
• W4386032323 cites W2018418660 @default.
• W4386032323 cites W2024492396 @default.
• W4386032323 cites W2026198465 @default.
• W4386032323 cites W2028094847 @default.
• W4386032323 cites W2031659092 @default.
• W4386032323 cites W2034400467 @default.
• W4386032323 cites W2042386784 @default.
• W4386032323 cites W2049553585 @default.
• W4386032323 cites W2051675224 @default.
• W4386032323 cites W2063550022 @default.
• W4386032323 cites W2072939418 @default.
• W4386032323 cites W2075294566 @default.
• W4386032323 cites W2092376065 @default.
• W4386032323 cites W2093613683 @default.
• W4386032323 cites W2101208037 @default.
• W4386032323 cites W2107940314 @default.
• W4386032323 cites W2111159494 @default.
• W4386032323 cites W2117692326 @default.
• W4386032323 cites W2123526148 @default.
• W4386032323 cites W2124312551 @default.
• W4386032323 cites W2128914615 @default.
• W4386032323 cites W2130503287 @default.
• W4386032323 cites W2141365513 @default.
• W4386032323 cites W2144439788 @default.
• W4386032323 cites W2167219679 @default.
• W4386032323 cites W2171120503 @default.
• W4386032323 cites W2190558971 @default.
• W4386032323 cites W2195251736 @default.
• W4386032323 cites W2232048567 @default.
• W4386032323 cites W2265062179 @default.
• W4386032323 cites W2299181842 @default.
• W4386032323 cites W2316228348 @default.
• W4386032323 cites W2317665158 @default.
• W4386032323 cites W2512526160 @default.
• W4386032323 cites W2517110957 @default.
• W4386032323 cites W2529727810 @default.
• W4386032323 cites W2560367415 @default.
• W4386032323 cites W2561499686 @default.
• W4386032323 cites W2565332095 @default.
• W4386032323 cites W2574604975 @default.
• W4386032323 cites W2575767307 @default.
• W4386032323 cites W2588336706 @default.
• W4386032323 cites W2593030814 @default.
• W4386032323 cites W2594836176 @default.
• W4386032323 cites W2598516816 @default.
• W4386032323 cites W2605086908 @default.
• W4386032323 cites W2606519264 @default.
• W4386032323 cites W2617314594 @default.
• W4386032323 cites W2774311191 @default.
• W4386032323 cites W2775328130 @default.
• W4386032323 cites W2782676239 @default.
• W4386032323 cites W2785803176 @default.
• W4386032323 cites W2789423409 @default.
• W4386032323 cites W2791235391 @default.
• W4386032323 cites W2792164419 @default.
• W4386032323 cites W2796207838 @default.
• W4386032323 cites W2799465346 @default.
• W4386032323 cites W2799746749 @default.
• W4386032323 cites W2886498337 @default.
• W4386032323 cites W2889052854 @default.
• W4386032323 cites W2889646458 @default.
• W4386032323 cites W2896872272 @default.
• W4386032323 cites W2897260867 @default.
• W4386032323 cites W2901630960 @default.
• W4386032323 cites W2904211489 @default.
• W4386032323 cites W2905644126 @default.
• W4386032323 cites W2907514116 @default.
• W4386032323 cites W2907885025 @default.
• W4386032323 cites W2911937431 @default.
• W4386032323 cites W2914396734 @default.
• W4386032323 cites W2916964158 @default.
• W4386032323 cites W2920985628 @default.
• W4386032323 cites W2922295383 @default.
• W4386032323 cites W2924232389 @default.
• W4386032323 cites W2935369648 @default.
• W4386032323 cites W2949644336 @default.
• W4386032323 cites W2955485789 @default.

• next