Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386032492> ?p ?o ?g. }
- W4386032492 endingPage "1651" @default.
- W4386032492 startingPage "1651" @default.
- W4386032492 abstract "Chronic neurodegenerative diseases are typically associated with oxidative stress conditions leading to neuronal cell death. We aimed to investigate the neuroprotective effect of three pyranocoumarins (decursin, decursinol angelate, and decursinol) targeting oxidative stress factors. Decursin (also known as dehydro-8-prenylnaringenin) is a prenylated coumarin compound consisting of a coumarin ring system with a prenyl group attached to one of the carbons in the ring. As a secondary metabolite of plants, pyranocoumarin decursin from Angelica gigas Nakai presented protective effects against glutamate-induced oxidative stress in HT22, a murine hippocampal neuronal cell line. Decursinol (DOH) is a metabolite of decursin, sharing same coumarin ring system but a slightly different chemical structure with the prenyl group replaced by a hydroxyl group (-OH). In our findings, DOH was ineffective while decursin was, suggesting that this prenyl structure may be important for compound absorption and neuroprotection. By diminishing the accumulation of intracellular reactive oxygen species as well as stimulating the expression of HO-1, decursin triggers the self-protection system in neuronal cells. Additionally, decursin also revealed an anti-apoptotic effect by inhibiting chromatin condensation and reducing the forming of annexin-V-positive cells." @default.
- W4386032492 created "2023-08-22" @default.
- W4386032492 creator A5001743084 @default.
- W4386032492 creator A5009056084 @default.
- W4386032492 creator A5034078083 @default.
- W4386032492 creator A5045383471 @default.
- W4386032492 creator A5056450018 @default.
- W4386032492 creator A5090681630 @default.
- W4386032492 date "2023-08-21" @default.
- W4386032492 modified "2023-10-18" @default.
- W4386032492 title "Neuroprotective Potential of Pyranocoumarins from Angelica gigas Nakai on Glutamate-Induced Hippocampal Cell Death" @default.
- W4386032492 cites W1600224209 @default.
- W4386032492 cites W161836838 @default.
- W4386032492 cites W1712314099 @default.
- W4386032492 cites W1908070090 @default.
- W4386032492 cites W1918276873 @default.
- W4386032492 cites W1965432000 @default.
- W4386032492 cites W1966148707 @default.
- W4386032492 cites W1977334935 @default.
- W4386032492 cites W2000754726 @default.
- W4386032492 cites W2013661589 @default.
- W4386032492 cites W2015233091 @default.
- W4386032492 cites W2016293448 @default.
- W4386032492 cites W2039158815 @default.
- W4386032492 cites W2039748871 @default.
- W4386032492 cites W2044911368 @default.
- W4386032492 cites W2045799265 @default.
- W4386032492 cites W2046672484 @default.
- W4386032492 cites W2051344987 @default.
- W4386032492 cites W2066346873 @default.
- W4386032492 cites W2078697141 @default.
- W4386032492 cites W2087737667 @default.
- W4386032492 cites W2087787328 @default.
- W4386032492 cites W2090032537 @default.
- W4386032492 cites W2092898068 @default.
- W4386032492 cites W2100996541 @default.
- W4386032492 cites W2104243204 @default.
- W4386032492 cites W2115023106 @default.
- W4386032492 cites W2120884178 @default.
- W4386032492 cites W2124524961 @default.
- W4386032492 cites W2140420634 @default.
- W4386032492 cites W2151158739 @default.
- W4386032492 cites W2168741793 @default.
- W4386032492 cites W2171239501 @default.
- W4386032492 cites W2195840178 @default.
- W4386032492 cites W2324956847 @default.
- W4386032492 cites W2340338776 @default.
- W4386032492 cites W2346162958 @default.
- W4386032492 cites W2609033839 @default.
- W4386032492 cites W2769467327 @default.
- W4386032492 cites W2773888341 @default.
- W4386032492 cites W3015885418 @default.
- W4386032492 cites W3082616876 @default.
- W4386032492 cites W3088387783 @default.
- W4386032492 cites W3155511665 @default.
- W4386032492 cites W3205950297 @default.
- W4386032492 cites W4213301132 @default.
- W4386032492 cites W4220812790 @default.
- W4386032492 cites W4290659578 @default.
- W4386032492 cites W4309602765 @default.
- W4386032492 doi "https://doi.org/10.3390/antiox12081651" @default.
- W4386032492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37627646" @default.
- W4386032492 hasPublicationYear "2023" @default.
- W4386032492 type Work @default.
- W4386032492 citedByCount "0" @default.
- W4386032492 crossrefType "journal-article" @default.
- W4386032492 hasAuthorship W4386032492A5001743084 @default.
- W4386032492 hasAuthorship W4386032492A5009056084 @default.
- W4386032492 hasAuthorship W4386032492A5034078083 @default.
- W4386032492 hasAuthorship W4386032492A5045383471 @default.
- W4386032492 hasAuthorship W4386032492A5056450018 @default.
- W4386032492 hasAuthorship W4386032492A5090681630 @default.
- W4386032492 hasBestOaLocation W43860324921 @default.
- W4386032492 hasConcept C170493617 @default.
- W4386032492 hasConcept C178790620 @default.
- W4386032492 hasConcept C181199279 @default.
- W4386032492 hasConcept C185592680 @default.
- W4386032492 hasConcept C190283241 @default.
- W4386032492 hasConcept C25498285 @default.
- W4386032492 hasConcept C2776151105 @default.
- W4386032492 hasConcept C2777477808 @default.
- W4386032492 hasConcept C2781338262 @default.
- W4386032492 hasConcept C31573885 @default.
- W4386032492 hasConcept C55493867 @default.
- W4386032492 hasConcept C57790582 @default.
- W4386032492 hasConcept C61174792 @default.
- W4386032492 hasConcept C71924100 @default.
- W4386032492 hasConcept C79879829 @default.
- W4386032492 hasConcept C98274493 @default.
- W4386032492 hasConceptScore W4386032492C170493617 @default.
- W4386032492 hasConceptScore W4386032492C178790620 @default.
- W4386032492 hasConceptScore W4386032492C181199279 @default.
- W4386032492 hasConceptScore W4386032492C185592680 @default.
- W4386032492 hasConceptScore W4386032492C190283241 @default.
- W4386032492 hasConceptScore W4386032492C25498285 @default.
- W4386032492 hasConceptScore W4386032492C2776151105 @default.
- W4386032492 hasConceptScore W4386032492C2777477808 @default.
- W4386032492 hasConceptScore W4386032492C2781338262 @default.