FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386046469> ?p ?o ?g. }

• W4386046469 abstract "The incidence of non-alcohol fatty liver disease (NAFLD) has been increasing annually with the improvement of living standards. Numerous epidemiological observations have linked sex hormone-binding protein (SHBG) levels to NAFLD. However, evidence of the causal role of SHBG in the development and progression of NAFLD is still absent. Therefore, a systematic assessment of the causal relationship is needed.A two-sample Mendelian randomisation (MR) analysis was conducted. Genome-wide association study (GWAS) data for SHBG were obtained online from the IEU database (ebi-a-GCST90012111) as exposure. GWAS data from the NAFLD of the Finngen consortium were used for preliminary analysis, while NAFLD data from another GWAS involving 8434 participants were used for replication and meta-analyses. Causal effects were investigated with inverse variance weighted (IVW), weighted median and MR-Egger regression. Sensitivity analyses including Cochran's Q test, leave-one-out analysis and MR-Egger intercept analysis were simultaneously conducted to assess heterogeneity and pleiotropy.After rigorous selection, 179 single-nucleotide polymorphisms (SNPs) were identified as strongly correlated instrumental variables. Preliminary analysis suggested a significant causal relationship between genetically determined serum SHBG levels and NAFLD [odds ratio (OR) IVW = .54, 95% confidence interval (CI) = .30-.98, p = .043], supported by the results of the replication analysis (ORIVW = .61, 95% CI = .46-.81, p = .0006) and further meta-analysis (OR = .59, 95% CI = .46-.77, p < .0001).The genetic tendency to high levels of SHBG was causally correlated with a reduced risk of NAFLD, indicating that circulating high levels of SHBG was a protective factor for NAFLD." @default.
• W4386046469 created "2023-08-23" @default.
• W4386046469 creator A5001971888 @default.
• W4386046469 creator A5050019300 @default.
• W4386046469 creator A5054335657 @default.
• W4386046469 creator A5057320489 @default.
• W4386046469 creator A5057424623 @default.
• W4386046469 creator A5068112395 @default.
• W4386046469 creator A5072761848 @default.
• W4386046469 date "2023-08-22" @default.
• W4386046469 modified "2023-10-10" @default.
• W4386046469 title "The relationship between sex hormone‐binding protein and non‐alcoholic fatty liver disease using Mendelian randomisation" @default.
• W4386046469 cites W1258381707 @default.
• W4386046469 cites W1492051437 @default.
• W4386046469 cites W1975306175 @default.
• W4386046469 cites W1996099825 @default.
• W4386046469 cites W2038429516 @default.
• W4386046469 cites W2046208657 @default.
• W4386046469 cites W2048613643 @default.
• W4386046469 cites W2098311087 @default.
• W4386046469 cites W2103783427 @default.
• W4386046469 cites W2115185894 @default.
• W4386046469 cites W2145774780 @default.
• W4386046469 cites W2161606547 @default.
• W4386046469 cites W2175624075 @default.
• W4386046469 cites W2265865881 @default.
• W4386046469 cites W2294346279 @default.
• W4386046469 cites W2327162184 @default.
• W4386046469 cites W2508708811 @default.
• W4386046469 cites W2579276161 @default.
• W4386046469 cites W2591791525 @default.
• W4386046469 cites W2767801219 @default.
• W4386046469 cites W2805983714 @default.
• W4386046469 cites W2810907329 @default.
• W4386046469 cites W2899974627 @default.
• W4386046469 cites W2941033601 @default.
• W4386046469 cites W2993398431 @default.
• W4386046469 cites W3004892753 @default.
• W4386046469 cites W3096809272 @default.
• W4386046469 cites W3131213308 @default.
• W4386046469 cites W3140030448 @default.
• W4386046469 cites W3150981945 @default.
• W4386046469 cites W3154897461 @default.
• W4386046469 cites W3155254720 @default.
• W4386046469 cites W3164001699 @default.
• W4386046469 cites W3211151734 @default.
• W4386046469 cites W4210393615 @default.
• W4386046469 cites W4229067787 @default.
• W4386046469 cites W4246077736 @default.
• W4386046469 cites W4280554493 @default.
• W4386046469 cites W4283688121 @default.
• W4386046469 cites W4291383362 @default.
• W4386046469 cites W4308318507 @default.
• W4386046469 cites W4353087856 @default.
• W4386046469 cites W63421749 @default.
• W4386046469 doi "https://doi.org/10.1111/eci.14082" @default.
• W4386046469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37605959" @default.
• W4386046469 hasPublicationYear "2023" @default.
• W4386046469 type Work @default.
• W4386046469 citedByCount "0" @default.
• W4386046469 crossrefType "journal-article" @default.
• W4386046469 hasAuthorship W4386046469A5001971888 @default.
• W4386046469 hasAuthorship W4386046469A5050019300 @default.
• W4386046469 hasAuthorship W4386046469A5054335657 @default.
• W4386046469 hasAuthorship W4386046469A5057320489 @default.
• W4386046469 hasAuthorship W4386046469A5057424623 @default.
• W4386046469 hasAuthorship W4386046469A5068112395 @default.
• W4386046469 hasAuthorship W4386046469A5072761848 @default.
• W4386046469 hasBestOaLocation W43860464691 @default.
• W4386046469 hasConcept C104317684 @default.
• W4386046469 hasConcept C106208931 @default.
• W4386046469 hasConcept C126322002 @default.
• W4386046469 hasConcept C127716648 @default.
• W4386046469 hasConcept C135763542 @default.
• W4386046469 hasConcept C143998085 @default.
• W4386046469 hasConcept C153209595 @default.
• W4386046469 hasConcept C156957248 @default.
• W4386046469 hasConcept C26207810 @default.
• W4386046469 hasConcept C2777911890 @default.
• W4386046469 hasConcept C2778772119 @default.
• W4386046469 hasConcept C2779134260 @default.
• W4386046469 hasConcept C2779901538 @default.
• W4386046469 hasConcept C2780439572 @default.
• W4386046469 hasConcept C2993967602 @default.
• W4386046469 hasConcept C30092816 @default.
• W4386046469 hasConcept C54355233 @default.
• W4386046469 hasConcept C60644358 @default.
• W4386046469 hasConcept C71315377 @default.
• W4386046469 hasConcept C71924100 @default.
• W4386046469 hasConcept C86803240 @default.
• W4386046469 hasConcept C95190672 @default.
• W4386046469 hasConceptScore W4386046469C104317684 @default.
• W4386046469 hasConceptScore W4386046469C106208931 @default.
• W4386046469 hasConceptScore W4386046469C126322002 @default.
• W4386046469 hasConceptScore W4386046469C127716648 @default.
• W4386046469 hasConceptScore W4386046469C135763542 @default.
• W4386046469 hasConceptScore W4386046469C143998085 @default.
• W4386046469 hasConceptScore W4386046469C153209595 @default.
• W4386046469 hasConceptScore W4386046469C156957248 @default.
• W4386046469 hasConceptScore W4386046469C26207810 @default.

• next