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- W4386047469 abstract "Abstract A major limitation in current Alzheimer’s disease (AD) research is the lack of the ability to measure cognitive performance at scale—robustly, remotely, and frequently. For the purposes of screening, recruitment, stratification, and longitudinal follow-up in clinical trials, there are no established online digital platforms validated against plasma biomarkers of AD. Here we report findings using a novel web-based platform that assessed different cognitive functions in AD patients (N=46) and elderly controls (N=53) who were also assessed for plasma biomarkers of AD (amyloid β42/40 ratio, pTau181, GFAP, NfL). Their performance was compared to a second, larger group of elderly controls (N=256). AD patients were significantly impaired across all digital cognitive tests, with performance correlating with plasma biomarker levels, particularly pTau181. These findings show how online testing can now be deployed in AD patients to measure cognitive function effectively and related to blood biomarkers of the disease." @default.
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- W4386047469 date "2023-08-22" @default.
- W4386047469 modified "2023-10-10" @default.
- W4386047469 title "Digital cognitive test performance and relationship to plasma biomarkers in Alzheimer’s disease" @default.
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- W4386047469 doi "https://doi.org/10.1101/2023.08.21.23293786" @default.
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