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- W4386055754 abstract "The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity, good drug-loading ability and sustained drug release properties. As a typical example, hyaluronic acid dressing (Healoderm) has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ulcers. However, the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound microenvironment. Due to the intricacy of diabetic wounds, antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice, although these medications are easily hindered by the hostile environment. In this case, scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds (such as high glucose and low pH) or combined with external stimuli (such as light or magnetic field) to achieve controllable drug release, gel degradation, and microenvironment improvements in order to overcome these clinical issues. These responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound dressings. Here, we review recent advances on responsive-hydrogel dressings towards diabetic wound healing, with focus on hydrogel structure design, the principle of responsiveness, and the behavior of degradation. Last but not least, the advantages and limitations of these responsive-hydrogels in clinical applications will also be discussed. We hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application." @default.
- W4386055754 created "2023-08-23" @default.
- W4386055754 creator A5004512291 @default.
- W4386055754 creator A5012241423 @default.
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- W4386055754 creator A5040558103 @default.
- W4386055754 creator A5042703422 @default.
- W4386055754 creator A5051032616 @default.
- W4386055754 creator A5057518143 @default.
- W4386055754 creator A5058114262 @default.
- W4386055754 date "2023-08-23" @default.
- W4386055754 modified "2023-10-14" @default.
- W4386055754 title "Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties" @default.
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