Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386055832> ?p ?o ?g. }
- W4386055832 endingPage "1694" @default.
- W4386055832 startingPage "1685" @default.
- W4386055832 abstract "Among fungal pathogens, infections by drug-resistant Candida species continue to pose a major challenge to healthcare. This study aimed to evaluate the activity of the bioactive natural product, penta-O-galloyl-β-d-glucose (PGG) against multidrug-resistant (MDR) Candida albicans, MDR Candida auris, and other MDR non-albicans Candida species. Here, we show that PGG has a minimum inhibitory concentration (MIC) of 0.25–8 μg mL–1 (0.265–8.5 μM) against three clinical strains of C. auris and a MIC of 0.25–4 μg mL–1 (0.265–4.25 μM) against a panel of other MDR Candida species. Our cytotoxicity studies found that PGG was well tolerated by human kidney, liver, and epithelial cells with an IC50 > 256 μg mL–1 (>272 μM). We also show that PGG is a high-capacity iron chelator and that deletion of key iron homeostasis genes in C. albicans rendered strains hypersensitive to PGG. In conclusion, PGG displayed potent anti-Candida activity with minimal cytotoxicity for human cells. We also found that the antifungal activity of PGG is mediated through an iron-chelating mechanism, suggesting that the compound could prove useful as a topical treatment for superficial Candida infections." @default.
- W4386055832 created "2023-08-23" @default.
- W4386055832 creator A5003018400 @default.
- W4386055832 creator A5040075148 @default.
- W4386055832 creator A5046262923 @default.
- W4386055832 creator A5048432540 @default.
- W4386055832 creator A5056444501 @default.
- W4386055832 creator A5057295318 @default.
- W4386055832 date "2023-08-22" @default.
- W4386055832 modified "2023-10-16" @default.
- W4386055832 title "Potent Antifungal Activity of Penta-<i>O</i>-galloyl-β-<scp>d</scp>-Glucose against Drug-Resistant <i>Candida albicans</i>, <i>Candida auris</i>, and Other Non-<i>albicans Candida</i> Species" @default.
- W4386055832 cites W1948733660 @default.
- W4386055832 cites W1971995316 @default.
- W4386055832 cites W1979435687 @default.
- W4386055832 cites W1989031118 @default.
- W4386055832 cites W1989834424 @default.
- W4386055832 cites W2012073610 @default.
- W4386055832 cites W2016562927 @default.
- W4386055832 cites W2028657301 @default.
- W4386055832 cites W2032481085 @default.
- W4386055832 cites W2032506326 @default.
- W4386055832 cites W2041611856 @default.
- W4386055832 cites W2046365958 @default.
- W4386055832 cites W2062120558 @default.
- W4386055832 cites W2083977136 @default.
- W4386055832 cites W2087273774 @default.
- W4386055832 cites W2095902301 @default.
- W4386055832 cites W2096863176 @default.
- W4386055832 cites W2125827320 @default.
- W4386055832 cites W2129905140 @default.
- W4386055832 cites W2135295352 @default.
- W4386055832 cites W2141439352 @default.
- W4386055832 cites W2145402329 @default.
- W4386055832 cites W2146920262 @default.
- W4386055832 cites W2150140261 @default.
- W4386055832 cites W2155606031 @default.
- W4386055832 cites W2157512355 @default.
- W4386055832 cites W2161755882 @default.
- W4386055832 cites W2169993696 @default.
- W4386055832 cites W2177456371 @default.
- W4386055832 cites W2244030311 @default.
- W4386055832 cites W2265485478 @default.
- W4386055832 cites W2322152800 @default.
- W4386055832 cites W2328449715 @default.
- W4386055832 cites W2344523925 @default.
- W4386055832 cites W2560839449 @default.
- W4386055832 cites W2589036275 @default.
- W4386055832 cites W2620852381 @default.
- W4386055832 cites W2740033601 @default.
- W4386055832 cites W2744057697 @default.
- W4386055832 cites W2766591388 @default.
- W4386055832 cites W2783209696 @default.
- W4386055832 cites W2803500445 @default.
- W4386055832 cites W2803848383 @default.
- W4386055832 cites W2901224237 @default.
- W4386055832 cites W2913299660 @default.
- W4386055832 cites W2947662217 @default.
- W4386055832 cites W3042581723 @default.
- W4386055832 cites W3087044387 @default.
- W4386055832 cites W3133643655 @default.
- W4386055832 cites W3164678070 @default.
- W4386055832 cites W4200094446 @default.
- W4386055832 cites W4210769079 @default.
- W4386055832 cites W4211178015 @default.
- W4386055832 cites W4289868866 @default.
- W4386055832 cites W4319166170 @default.
- W4386055832 cites W4380728309 @default.
- W4386055832 cites W67833837 @default.
- W4386055832 doi "https://doi.org/10.1021/acsinfecdis.3c00113" @default.
- W4386055832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37607350" @default.
- W4386055832 hasPublicationYear "2023" @default.
- W4386055832 type Work @default.
- W4386055832 citedByCount "0" @default.
- W4386055832 crossrefType "journal-article" @default.
- W4386055832 hasAuthorship W4386055832A5003018400 @default.
- W4386055832 hasAuthorship W4386055832A5040075148 @default.
- W4386055832 hasAuthorship W4386055832A5046262923 @default.
- W4386055832 hasAuthorship W4386055832A5048432540 @default.
- W4386055832 hasAuthorship W4386055832A5056444501 @default.
- W4386055832 hasAuthorship W4386055832A5057295318 @default.
- W4386055832 hasBestOaLocation W43860558321 @default.
- W4386055832 hasConcept C109316439 @default.
- W4386055832 hasConcept C114851261 @default.
- W4386055832 hasConcept C133936738 @default.
- W4386055832 hasConcept C145081991 @default.
- W4386055832 hasConcept C176947019 @default.
- W4386055832 hasConcept C202751555 @default.
- W4386055832 hasConcept C2779548794 @default.
- W4386055832 hasConcept C2780917455 @default.
- W4386055832 hasConcept C2909786013 @default.
- W4386055832 hasConcept C2991737395 @default.
- W4386055832 hasConcept C4937899 @default.
- W4386055832 hasConcept C55493867 @default.
- W4386055832 hasConcept C86803240 @default.
- W4386055832 hasConcept C89423630 @default.
- W4386055832 hasConceptScore W4386055832C109316439 @default.
- W4386055832 hasConceptScore W4386055832C114851261 @default.
- W4386055832 hasConceptScore W4386055832C133936738 @default.