FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386065082> ?p ?o ?g. }

• W4386065082 abstract "Ly6C lo monocytes are a myeloid subset that specializes in the surveillance of vascular endothelium. Ly6C lo monocytes have been shown to derive from Ly6C hi monocytes. NOTCH2 signaling has been implicated as a trigger for Ly6C lo monocyte development, but the basis for this effect is unclear. Here, we examined the impact of NOTCH2 signaling of myeloid progenitors on the development of Ly6C lo monocytes in vitro. NOTCH2 signaling induced by delta-like ligand 1 (DLL1) efficiently induced the transition of Ly6C hi TREML4 – monocytes into Ly6C lo TREML4 + monocytes. We further identified two additional transcriptional requirements for development of Ly6C lo monocytes. Deletion of BCL6 from myeloid progenitors abrogated development of Ly6C lo monocytes. IRF2 was also required for Ly6C lo monocyte development in a cell-intrinsic manner. DLL1-induced in vitro transition into Ly6C lo TREML4 + monocytes required IRF2 but unexpectedly could occur in the absence of NUR77 or BCL6. These results imply a transcriptional hierarchy for these factors in controlling Ly6C lo monocyte development." @default.
• W4386065082 created "2023-08-23" @default.
• W4386065082 creator A5004831350 @default.
• W4386065082 creator A5014531040 @default.
• W4386065082 creator A5036191257 @default.
• W4386065082 creator A5080891366 @default.
• W4386065082 creator A5085864834 @default.
• W4386065082 creator A5090464003 @default.
• W4386065082 date "2023-08-22" @default.
• W4386065082 modified "2023-10-03" @default.
• W4386065082 title "<i>Bcl6</i> , <i>Irf2</i> , and <i>Notch2</i> promote nonclassical monocyte development" @default.
• W4386065082 cites W101740868 @default.
• W4386065082 cites W1533804294 @default.
• W4386065082 cites W1557119871 @default.
• W4386065082 cites W1587300234 @default.
• W4386065082 cites W1956258286 @default.
• W4386065082 cites W1965331949 @default.
• W4386065082 cites W1966100182 @default.
• W4386065082 cites W1968758858 @default.
• W4386065082 cites W1973476558 @default.
• W4386065082 cites W1975672275 @default.
• W4386065082 cites W1979977043 @default.
• W4386065082 cites W1985502949 @default.
• W4386065082 cites W1991311051 @default.
• W4386065082 cites W1992961556 @default.
• W4386065082 cites W1993401937 @default.
• W4386065082 cites W2000927180 @default.
• W4386065082 cites W2025748388 @default.
• W4386065082 cites W2025804504 @default.
• W4386065082 cites W2026125174 @default.
• W4386065082 cites W2026578487 @default.
• W4386065082 cites W2028735719 @default.
• W4386065082 cites W2032197035 @default.
• W4386065082 cites W2038123514 @default.
• W4386065082 cites W2047044941 @default.
• W4386065082 cites W2050224211 @default.
• W4386065082 cites W2052904272 @default.
• W4386065082 cites W2054540776 @default.
• W4386065082 cites W2054581136 @default.
• W4386065082 cites W2057793188 @default.
• W4386065082 cites W2068592712 @default.
• W4386065082 cites W2080844075 @default.
• W4386065082 cites W2091253809 @default.
• W4386065082 cites W2094823633 @default.
• W4386065082 cites W2094930641 @default.
• W4386065082 cites W2106274007 @default.
• W4386065082 cites W2106315019 @default.
• W4386065082 cites W2112117215 @default.
• W4386065082 cites W2123480703 @default.
• W4386065082 cites W2127605217 @default.
• W4386065082 cites W2127897152 @default.
• W4386065082 cites W2137835860 @default.
• W4386065082 cites W2146604395 @default.
• W4386065082 cites W2148839219 @default.
• W4386065082 cites W2151362823 @default.
• W4386065082 cites W2153406260 @default.
• W4386065082 cites W2154379321 @default.
• W4386065082 cites W2161057248 @default.
• W4386065082 cites W2171029424 @default.
• W4386065082 cites W2512649632 @default.
• W4386065082 cites W2548678995 @default.
• W4386065082 cites W2559249883 @default.
• W4386065082 cites W2615409887 @default.
• W4386065082 cites W2616630127 @default.
• W4386065082 cites W2747823021 @default.
• W4386065082 cites W2794592597 @default.
• W4386065082 cites W2803822216 @default.
• W4386065082 cites W2916738215 @default.
• W4386065082 cites W2941620462 @default.
• W4386065082 cites W2991528977 @default.
• W4386065082 cites W3035965283 @default.
• W4386065082 cites W3167784169 @default.
• W4386065082 cites W3205926718 @default.
• W4386065082 cites W4308891624 @default.
• W4386065082 cites W4386065082 @default.
• W4386065082 cites W842194636 @default.
• W4386065082 doi "https://doi.org/10.1073/pnas.2220853120" @default.
• W4386065082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37607223" @default.
• W4386065082 hasPublicationYear "2023" @default.
• W4386065082 type Work @default.
• W4386065082 citedByCount "1" @default.
• W4386065082 countsByYear W43860650822023 @default.
• W4386065082 crossrefType "journal-article" @default.
• W4386065082 hasAuthorship W4386065082A5004831350 @default.
• W4386065082 hasAuthorship W4386065082A5014531040 @default.
• W4386065082 hasAuthorship W4386065082A5036191257 @default.
• W4386065082 hasAuthorship W4386065082A5080891366 @default.
• W4386065082 hasAuthorship W4386065082A5085864834 @default.
• W4386065082 hasAuthorship W4386065082A5090464003 @default.
• W4386065082 hasBestOaLocation W43860650821 @default.
• W4386065082 hasConcept C201750760 @default.
• W4386065082 hasConcept C203014093 @default.
• W4386065082 hasConcept C2779282312 @default.
• W4386065082 hasConcept C2781184567 @default.
• W4386065082 hasConcept C28328180 @default.
• W4386065082 hasConcept C502942594 @default.
• W4386065082 hasConcept C86803240 @default.
• W4386065082 hasConcept C95444343 @default.
• W4386065082 hasConceptScore W4386065082C201750760 @default.
• W4386065082 hasConceptScore W4386065082C203014093 @default.

• next