Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386067939> ?p ?o ?g. }
- W4386067939 endingPage "2127" @default.
- W4386067939 startingPage "2127" @default.
- W4386067939 abstract "The development of several vaccines against the SARS-CoV2 virus and their application in millions of people have shown efficacy and safety in the transfer of genes to muscle turning this tissue into a protein-producing factory. Established advanced liver fibrosis, is characterized by replacement of hepatic parenchyma by tissue scar, mostly collagen type I, with increased profibrogenic and proinflammatory molecules gene expression. Matrix metalloproteinase 8 (MMP-8) is an interstitial collagen-degrading proenzyme acting preferentially on collagen type I when activated. This study was carried out to elucidate the effect of an intramuscularly delivered adenoviral vector containing proMMP-8 gene cDNA (AdhMMP8) in male Wistar rats with experimental advanced liver fibrosis induced by thioacetamide. Therapeutic effects were monitored after 1, 2, or 3 weeks of a single dose (3 × 1011 vp/kg) of AdhMMP8. Circulating and liver concentration of MMP-8 protein remained constant; hepatic fibrosis decreased up to 48%; proinflammatory and profibrogenic genes expression diminished: TNF-α 2.28-fold, IL-1 1.95-fold, Col 1A1 4-fold, TGF-β1 3-fold and CTGF 2-fold; and antifibrogenic genes expression raised, MMP-9 2.8-fold and MMP-1 10-fold. Our data proposes that the administration of AdhMMP8 in muscle is safe and effective in achieving liver fibrosis regression at a comparable extent as when the adenoviral vector is delivered systemically to reach the liver, using a minimally invasive procedure." @default.
- W4386067939 created "2023-08-23" @default.
- W4386067939 creator A5019759526 @default.
- W4386067939 creator A5034256115 @default.
- W4386067939 creator A5037574864 @default.
- W4386067939 creator A5047481359 @default.
- W4386067939 creator A5052140861 @default.
- W4386067939 creator A5060647631 @default.
- W4386067939 creator A5069543076 @default.
- W4386067939 creator A5084104543 @default.
- W4386067939 creator A5085501737 @default.
- W4386067939 creator A5090949199 @default.
- W4386067939 date "2023-08-22" @default.
- W4386067939 modified "2023-10-03" @default.
- W4386067939 title "AdhMMP8 Vector Administration in Muscle: An Alternate Strategy to Regress Hepatic Fibrosis" @default.
- W4386067939 cites W1452451700 @default.
- W4386067939 cites W1561512560 @default.
- W4386067939 cites W1925296288 @default.
- W4386067939 cites W1987610410 @default.
- W4386067939 cites W2005317484 @default.
- W4386067939 cites W2014495927 @default.
- W4386067939 cites W2019820968 @default.
- W4386067939 cites W2021484612 @default.
- W4386067939 cites W2026788409 @default.
- W4386067939 cites W2028769422 @default.
- W4386067939 cites W2035504341 @default.
- W4386067939 cites W2036615945 @default.
- W4386067939 cites W2041983212 @default.
- W4386067939 cites W2067202030 @default.
- W4386067939 cites W2082275088 @default.
- W4386067939 cites W2083737137 @default.
- W4386067939 cites W2084688412 @default.
- W4386067939 cites W2087395223 @default.
- W4386067939 cites W2095046356 @default.
- W4386067939 cites W2107277218 @default.
- W4386067939 cites W2112775495 @default.
- W4386067939 cites W2113207934 @default.
- W4386067939 cites W2134812217 @default.
- W4386067939 cites W2142988890 @default.
- W4386067939 cites W2144921016 @default.
- W4386067939 cites W2145743018 @default.
- W4386067939 cites W2147270124 @default.
- W4386067939 cites W2147786790 @default.
- W4386067939 cites W2150221874 @default.
- W4386067939 cites W2154401382 @default.
- W4386067939 cites W2165178639 @default.
- W4386067939 cites W2166475106 @default.
- W4386067939 cites W2167224247 @default.
- W4386067939 cites W2167794093 @default.
- W4386067939 cites W2170381415 @default.
- W4386067939 cites W2171476567 @default.
- W4386067939 cites W2192080449 @default.
- W4386067939 cites W2344852776 @default.
- W4386067939 cites W2536745189 @default.
- W4386067939 cites W2560971730 @default.
- W4386067939 cites W2607704951 @default.
- W4386067939 cites W2789986561 @default.
- W4386067939 cites W2922106787 @default.
- W4386067939 cites W3019034047 @default.
- W4386067939 cites W3027139056 @default.
- W4386067939 cites W3042383115 @default.
- W4386067939 cites W3095484986 @default.
- W4386067939 cites W3111255098 @default.
- W4386067939 cites W3127329393 @default.
- W4386067939 cites W3127821066 @default.
- W4386067939 cites W3153508314 @default.
- W4386067939 cites W3199571792 @default.
- W4386067939 cites W4205483821 @default.
- W4386067939 cites W4205592936 @default.
- W4386067939 cites W4205924067 @default.
- W4386067939 cites W4225009249 @default.
- W4386067939 cites W4245823960 @default.
- W4386067939 cites W4283164885 @default.
- W4386067939 cites W4294216491 @default.
- W4386067939 cites W4300630316 @default.
- W4386067939 cites W4306925945 @default.
- W4386067939 cites W4361000000 @default.
- W4386067939 cites W4379054651 @default.
- W4386067939 cites W4382196372 @default.
- W4386067939 doi "https://doi.org/10.3390/cells12172127" @default.
- W4386067939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37681859" @default.
- W4386067939 hasPublicationYear "2023" @default.
- W4386067939 type Work @default.
- W4386067939 citedByCount "0" @default.
- W4386067939 crossrefType "journal-article" @default.
- W4386067939 hasAuthorship W4386067939A5019759526 @default.
- W4386067939 hasAuthorship W4386067939A5034256115 @default.
- W4386067939 hasAuthorship W4386067939A5037574864 @default.
- W4386067939 hasAuthorship W4386067939A5047481359 @default.
- W4386067939 hasAuthorship W4386067939A5052140861 @default.
- W4386067939 hasAuthorship W4386067939A5060647631 @default.
- W4386067939 hasAuthorship W4386067939A5069543076 @default.
- W4386067939 hasAuthorship W4386067939A5084104543 @default.
- W4386067939 hasAuthorship W4386067939A5085501737 @default.
- W4386067939 hasAuthorship W4386067939A5090949199 @default.
- W4386067939 hasBestOaLocation W43860679391 @default.
- W4386067939 hasConcept C104317684 @default.
- W4386067939 hasConcept C109523444 @default.