Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386069124> ?p ?o ?g. }
- W4386069124 abstract "The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic. Here, we dissect the role of LSD1 and its demethylase activity in gene regulation and cell fate transition. Surprisingly, the catalytic inactivation of LSD1 has a mild impact on gene expression and cellular differentiation whereas the loss of LSD1 protein de-represses enhancers globally and impairs cell fate transition. LSD1 deletion increases H3K27ac levels and P300 occupancy at LSD1-targeted enhancers. The gain of H3K27ac catalyzed by P300/CBP, not the loss of CoREST complex components from chromatin, contributes to the transcription de-repression of LSD1 targets and differentiation defects caused by LSD1 loss. Together, our study demonstrates a demethylase-independent role of LSD1 in regulating enhancers and cell fate transition, providing insight into treating diseases driven by LSD1 mutations and misregulation." @default.
- W4386069124 created "2023-08-23" @default.
- W4386069124 creator A5017090022 @default.
- W4386069124 creator A5018536408 @default.
- W4386069124 creator A5021033448 @default.
- W4386069124 creator A5040985260 @default.
- W4386069124 creator A5050957282 @default.
- W4386069124 creator A5062628423 @default.
- W4386069124 creator A5092675207 @default.
- W4386069124 date "2023-08-22" @default.
- W4386069124 modified "2023-10-17" @default.
- W4386069124 title "Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition" @default.
- W4386069124 cites W1964813856 @default.
- W4386069124 cites W1965027943 @default.
- W4386069124 cites W1965813899 @default.
- W4386069124 cites W1966538534 @default.
- W4386069124 cites W1981030303 @default.
- W4386069124 cites W1993243592 @default.
- W4386069124 cites W2000177129 @default.
- W4386069124 cites W2000728270 @default.
- W4386069124 cites W2009089729 @default.
- W4386069124 cites W2011263116 @default.
- W4386069124 cites W2013785611 @default.
- W4386069124 cites W2022825464 @default.
- W4386069124 cites W2022884475 @default.
- W4386069124 cites W2024800350 @default.
- W4386069124 cites W2034156554 @default.
- W4386069124 cites W2040365591 @default.
- W4386069124 cites W2044830131 @default.
- W4386069124 cites W2045996598 @default.
- W4386069124 cites W2050723217 @default.
- W4386069124 cites W2054621094 @default.
- W4386069124 cites W2059171091 @default.
- W4386069124 cites W2070613990 @default.
- W4386069124 cites W2072924157 @default.
- W4386069124 cites W2073233675 @default.
- W4386069124 cites W2075928340 @default.
- W4386069124 cites W2076427374 @default.
- W4386069124 cites W2094221767 @default.
- W4386069124 cites W2097751554 @default.
- W4386069124 cites W2102619694 @default.
- W4386069124 cites W2104198050 @default.
- W4386069124 cites W2108234281 @default.
- W4386069124 cites W2121842901 @default.
- W4386069124 cites W2123564569 @default.
- W4386069124 cites W2131478115 @default.
- W4386069124 cites W2142303705 @default.
- W4386069124 cites W2151743649 @default.
- W4386069124 cites W2154746182 @default.
- W4386069124 cites W2155445544 @default.
- W4386069124 cites W2158074192 @default.
- W4386069124 cites W2160240181 @default.
- W4386069124 cites W2169456326 @default.
- W4386069124 cites W2170551349 @default.
- W4386069124 cites W2170748964 @default.
- W4386069124 cites W2170830174 @default.
- W4386069124 cites W2179438025 @default.
- W4386069124 cites W2260480416 @default.
- W4386069124 cites W2337375997 @default.
- W4386069124 cites W2340178529 @default.
- W4386069124 cites W2341539131 @default.
- W4386069124 cites W2403341971 @default.
- W4386069124 cites W2412386353 @default.
- W4386069124 cites W2591968025 @default.
- W4386069124 cites W2604847558 @default.
- W4386069124 cites W2611717200 @default.
- W4386069124 cites W2613966178 @default.
- W4386069124 cites W2739001429 @default.
- W4386069124 cites W2758743773 @default.
- W4386069124 cites W2758789825 @default.
- W4386069124 cites W2761896392 @default.
- W4386069124 cites W2762828108 @default.
- W4386069124 cites W2770177949 @default.
- W4386069124 cites W2776816011 @default.
- W4386069124 cites W2787683044 @default.
- W4386069124 cites W2788202982 @default.
- W4386069124 cites W2791963264 @default.
- W4386069124 cites W2792453707 @default.
- W4386069124 cites W2803754954 @default.
- W4386069124 cites W2860815399 @default.
- W4386069124 cites W2919408146 @default.
- W4386069124 cites W2924703365 @default.
- W4386069124 cites W2928665623 @default.
- W4386069124 cites W2947662005 @default.
- W4386069124 cites W2950464315 @default.
- W4386069124 cites W2951506174 @default.
- W4386069124 cites W2953622121 @default.
- W4386069124 cites W2993378407 @default.
- W4386069124 cites W3008180407 @default.
- W4386069124 cites W3008324499 @default.
- W4386069124 cites W3015259075 @default.
- W4386069124 cites W3022526195 @default.
- W4386069124 cites W3082858723 @default.
- W4386069124 cites W3092891279 @default.
- W4386069124 cites W3097919600 @default.
- W4386069124 cites W3102624934 @default.
- W4386069124 cites W3118886003 @default.
- W4386069124 cites W3164692211 @default.
- W4386069124 cites W3175752499 @default.
- W4386069124 cites W3199510140 @default.