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- W4386069270 abstract "Introduction Streptococcus pyogenes (also known as Group A Streptococcus, Strep A) is an obligate human pathogen with significant global morbidity and mortality. Transmission is believed to occur primarily between individuals via respiratory droplets, however knowledge about other potential sources of transmission via aerosols or the environment is limited. Such knowledge is required to design optimal interventions to control transmission, particularly in endemic settings. We aimed to detail experimental methodology to assess the transmission potential of Strep A in a clinical environment.Materials and methods We will examine potential sources of transmission in up to 20 participants recruited to the Controlled human infection for penicillin against Streptococcus pyogenes (CHIPS) Trial. Three approaches to understanding transmission will be used: the use of selective agar settle plates to capture possible droplet or airborne spread of Strep A; measurement of the possible distance of Strep A droplet spread during conversation; and environmental swabbing of personal and common high-touch items to detect the presence of Strep A on hard and soft surfaces. All methods are designed to allow for an assessment of transmission potential by symptomatic, asymptomatic, and non-cases. Ethical approval has been obtained through Bellberry Human Research Ethics Committee (Approval 2021-03-295). Trial Registration number: ACTRN12621000751875.Discussion Any results elicited from these experiments will be of benefit to the scientific literature in improving our knowledge of opportunities to prevent Strep A transmission as a direct component of the primordial prevention of rheumatic fever. Findings will be reported at local, national, and international conferences and in peer-reviewed journals." @default.
- W4386069270 created "2023-08-23" @default.
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- W4386069270 date "2023-08-21" @default.
- W4386069270 modified "2023-09-25" @default.
- W4386069270 title "Editor response for version 1" @default.
- W4386069270 doi "https://doi.org/10.1099/acmi.0.000650.v1.5" @default.
- W4386069270 hasPublicationYear "2023" @default.
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