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• W4386070278 abstract "The Sleep Apnea Multi-level Surgery (SAMS) randomised clinical trial showed surgery improved outcomes at 6 months compared to ongoing medical management in patients with moderate or severe obstructive sleep apnea (OSA) who failed continuous positive airway pressure therapy. This study reports the long-term outcomes of the multi-level surgery as a case series.Surgical participants were reassessed >2years post-operatively with the same outcomes reported in the main SAMS trial. Primary outcomes were apnea-hypopnea index (AHI) and Epworth Sleepiness Scale (ESS), with secondary outcomes including other polysomnography measures, symptoms, quality of life, and adverse events. Long-term effectiveness (baseline to long-term follow-up) and interval changes (six-month to long-term follow-up) were assessed using mixed effects regression models. Control participants were also reassessed for rate of subsequent surgery and outcomes.36/48 (75%) of surgical participants were re-evaluated (mean [SD]) 3.5 [1.0] years following surgery, with 29 undergoing polysomnography. AHI was 41/hour [23] at pre-operative baseline and 21/hour [18] at follow-up, representing persistent improvement of -24/hour [95% CI -32, -17; p<0.001]. ESS was 12.3 [3.5] at baseline and 5.5 [3.9] at follow-up, representing persistent improvement of -6.8 [95% CI -8.3, -5.4; p<0.001]. Secondary outcomes were improved long-term, and adverse events were minor. Interval change analysis suggests stability of outcomes. 36/43 (84%) of the control participants were re-evaluated, with 25 (69%) reporting subsequent surgery, with symptom and quality of life improvements.Multi-level upper airway surgery improves OSA burden with long-term maintenance of treatment effect in adults with moderate or severe OSA in whom conventional therapy failed." @default.
• W4386070278 created "2023-08-23" @default.
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• W4386070278 date "2023-08-22" @default.
• W4386070278 modified "2023-10-10" @default.
• W4386070278 title "Sleep apnea multi-level surgery trial: long-term observational outcomes" @default.
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• W4386070278 doi "https://doi.org/10.1093/sleep/zsad218" @default.
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• W4386070278 hasPublicationYear "2023" @default.
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